DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RNF130 and APE3

DIOPT Version :9

Sequence 1:	XP_024301897.1	Gene:	RNF130 / 55819	HGNCID:	18280	Length:	448	Species:	Homo sapiens
Sequence 2:	NP_009845.2	Gene:	APE3 / 852589	SGDID:	S000000490	Length:	537	Species:	Saccharomyces cerevisiae

Alignment Length:	164	Identity:	50/164 - (30%)
Similarity:	76/164 - (46%)	Gaps:	22/164 - (13%)

- Green bases have known domain annotations that are detailed below.

Human    32 QEYYTALINVTVQ--EPGRGAPLTFRIDRGRYGLDSPKAEVRGQVLAPLPLHGVA------DHLG 88
            |:||    :|::|  |...|..::|.:.....|  ...|......|:| |:.|..      .:||
Yeast   129 QDYY----DVSLQEFEALSGKIISFNLSDAETG--KSFANTTAFALSP-PVDGFVGKLVEIPNLG 186

Human    89 CDPQT-RFFVPP--NIKQWIALLQRGNCTFKEKISRAAFHNAVAVVIYNN--KSKEE-PVTMTHP 147
            |:.:. ...|||  |.|| |||::||.|.|.:|.:.|......|||||:|  ||||. ..|:..|
Yeast   187 CEEKDYASVVPPRHNEKQ-IALIERGKCPFGDKSNLAGKFGFTAVVIYDNEPKSKEGLHGTLGEP 250

Human   148 GTGDIIAVMITELRGKDILSYLEKNISVQMTIAV 181
            ....:..|.:....||.:::.:..||...:..|:
Yeast   251 TKHTVATVGVPYKVGKKLIANIALNIDYSLYFAM 284

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RNF130	XP_024301897.1	PA_GRAIL_like	40..179	CDD:239037	46/152 (30%)
		zf-rbx1	<197..>306	CDD:331150
		RING_Ubox	262..310	CDD:327409
APE3	NP_009845.2	M28_SGAP_like	78..506	CDD:349873	50/164 (30%)
APE3	NP_009845.2	PA_ScAPY_like	155..284	CDD:239045	41/132 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000832
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910