Protein Alignment RNF130 and gol

DIOPT Version :10

• Sequence 1: NP_060904.2
• Gene: RNF130 / 55819
• HGNCID: 18280
• Length: 419
• Species: Homo sapiens
• Sequence 2: NP_001163300.1
• Gene: gol / 38006
• FlyBaseID: FBgn0004919
• Length: 601
• Species: Drosophila melanogaster
• Alignment Length: 290
• Identity: 125/290 - (43%)
• Similarity: 170/290 - (58%)
• Gaps: 10/290 - (3%)

Human    34 YYTALINVTVQEPGRG-APLTFRIDRGRYGLDSPKAEVRGQVLAPLPLHGVADHLGCDPQTRFF- 96
            |..|.:|.:..|.|.. ..:.|..::.||| :.....|.|:::........:|...|.|..|..
  Fly    67 YNYAFLNWSYVEHGNMLCNMEFAQEQARYG-EGKVLNVTGRLIHITATDNFSDDYACTPYIRGTL 130

Human    97 ---VPPNIKQWIALLQRGNCTFKEKISRAAFHNAVAVVIYNNKSKEEPVTMTHPG-TGDIIAVMI 157
               :|...:.||||::||.|||:||:......||..|:|||:|...:...|...| |.:|.||:.
  Fly   131 GAPIPDKGETWIALVRRGRCTFEEKVKHVYQQNAAGVIIYNDKQVMQLEKMQIKGKTRNIAAVIT 195

Human   158 TELRGKDILSYLEKNISVQMTIAVGTR--MPPKNFSRGSLVFVSISFIVLMIISSAWLIFYFIQK 220
            .:..|:|:...|:|..:|.::|..|.|  ....:.:|.|::|||||||||||||..|||||:||:
  Fly   196 YQNIGQDLSLTLDKGYNVTISIIEGRRGVRTISSLNRTSVLFVSISFIVLMIISLVWLIFYYIQR 260

Human   221 IRYTNARDRNQRRLGDAAKKAISKLTTRTVKKGDKETDPDFDHCAVCIESYKQNDVVRILPCKHV 285
            .||..|:|:..|.|....||||.|:.|:|.|..| |.|.|.|.||:|||:||..|.:|||||||.
  Fly   261 FRYMQAKDQQSRNLCSVTKKAIMKIPTKTGKFSD-EKDLDSDCCAICIEAYKPTDTIRILPCKHE 324

Human   286 FHKSCVDPWLSEHCTCPMCKLNILKALGIV 315
            |||:|:||||.||.|||||||::||..|.|
  Fly   325 FHKNCIDPWLIEHRTCPMCKLDVLKFYGYV 354

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RNF130	NP_060904.2	PA_GRAIL_like	40..179	CDD:239037	43/144 (30%)
		HRD1	<197..>306	CDD:227568	69/108 (64%)
		RING-H2_RNF130	262..310	CDD:319717	33/47 (70%)
gol	NP_001163300.1	PA_GRAIL_like	73..217	CDD:239037	43/144 (30%)
		HRD1	<237..>347	CDD:227568	71/110 (65%)
		RING-H2_RNF130-like	302..347	CDD:438330	32/44 (73%)