DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ap2a1 and AP-2alpha

DIOPT Version :9

Sequence 1:	XP_009297842.1	Gene:	ap2a1 / 558153	ZFINID:	ZDB-GENE-090302-2	Length:	984	Species:	Danio rerio
Sequence 2:	NP_995607.1	Gene:	AP-2alpha / 33211	FlyBaseID:	FBgn0264855	Length:	952	Species:	Drosophila melanogaster

Alignment Length:	967	Identity:	651/967 - (67%)
Similarity:	756/967 - (78%)	Gaps:	53/967 - (5%)

- Green bases have known domain annotations that are detailed below.

Zfish    23 CKSKEAEIKRINKELANIRSKFKGDKALDGYSKKKYVCKLLFIFLLGHDIDFGHMEAVNLLSSNK 87
            |||||||:||||||||||||||||||.||||.|||||||||||||||||||||||||||||||||
  Fly    34 CKSKEAEVKRINKELANIRSKFKGDKTLDGYQKKKYVCKLLFIFLLGHDIDFGHMEAVNLLSSNK 98

Zfish    88 YTEKQIGYLFISVLVNSNSELIRLINNAIKNDLSSRNPTFMCLALHCIANVGSREMAEAFAGEIP 152
            |:||||||||||||||:||:|||||..:|||||.||||..:.|||.||||:|||:|||:|:.|||
  Fly    99 YSEKQIGYLFISVLVNTNSDLIRLIIQSIKNDLQSRNPVHVNLALQCIANIGSRDMAESFSNEIP 163

Zfish   153 RILVAGDTMDSVKQSAALCLLRLYKTSPDLVLMGEWTSRVVHLLNDQHMGVVTAAISLITCLSQK 217
            ::||:|||||.||||||||||||:::|||::..||||||::||||||||||||||.|||..|.::
  Fly   164 KLLVSGDTMDVVKQSAALCLLRLFRSSPDIIPGGEWTSRIIHLLNDQHMGVVTAATSLIDALVKR 228

Zfish   218 NPDEFKTCVSLAVSRLSRIVSSASTDLQDYTYYFVPAPWLSCKLLRLLQCY-PPPEDGAVKGRLV 281
            ||||:|.||:||||||||||:::.|||||||||||||||||.|||||||.| |..|:..|:.||.
  Fly   229 NPDEYKGCVNLAVSRLSRIVTASYTDLQDYTYYFVPAPWLSVKLLRLLQNYNPVTEEAGVRARLN 293

Zfish   282 ECLETILNKAQEPPKSKKVQHSNAKNAILFEAISLIIHYDSEPNLLVRACNQLGQFLQHRETNLR 346
            |.|||||||||||||||||||||||||:|||||:||||.||||||||||||||||||.:||||||
  Fly   294 ETLETILNKAQEPPKSKKVQHSNAKNAVLFEAINLIIHSDSEPNLLVRACNQLGQFLSNRETNLR 358

Zfish   347 YLALESMCTLASSEFSHEAVKTHIETVINALKTERDVSVRQRAADLLYAMCDRSNAKQIVAEMLS 411
            ||||||||.||:||||||.||.|.|.||.::|.|:||||||.|.|||||||||.||::||.|||:
  Fly   359 YLALESMCHLATSEFSHEEVKKHQEVVILSMKMEKDVSVRQMAVDLLYAMCDRGNAEEIVQEMLN 423

Zfish   412 YLETADYSIREEMVLKVAILAEKYAVDYSWYVDTILNLIRIAGDYVSEEVWYRVIQIVINRDDVQ 476
            |||||||||||||||||||||||||.||:||||.|||||||||||||||||||||||||||::||
  Fly   424 YLETADYSIREEMVLKVAILAEKYATDYTWYVDVILNLIRIAGDYVSEEVWYRVIQIVINREEVQ 488

Zfish   477 GYAAKTVFEALQAPACHENMVKVGGYILGEFGNLIAGDPRSSPLVQFNLLHSKFHLCSVPTRALL 541
            ||||||||||||||||||||||||||||||||||||||.||:|||||.|||||:||||..|||||
  Fly   489 GYAAKTVFEALQAPACHENMVKVGGYILGEFGNLIAGDSRSAPLVQFKLLHSKYHLCSPMTRALL 553

Zfish   542 LSAYIKFINLFPETKSTIQEVLRSDSQIRNSDVELQQRAVEYLKLSSIASTDVLATVLEEMPPFP 606
            ||.||||||||||.::.||:|.|..|.:|::|.||||||.|||:||.:||||||||||||||.||
  Fly   554 LSTYIKFINLFPEIRTNIQDVFRQHSNLRSADAELQQRASEYLQLSIVASTDVLATVLEEMPSFP 618

Zfish   607 ERESSILAKLKKKKGPGAVSVNELEEGKREGGELNGGGGER--GGDNSTIAASNASTPSPSADLL 669
            ||||||||.||||| ||.|..||:.|.|......:......  ...:|.:..|||:|     |||
  Fly   619 ERESSILAVLKKKK-PGRVPENEIRESKSPAPLTSAAQNNALVNNSHSKLNNSNANT-----DLL 677

Zfish   670 GLRTGPQVSAAPPS--AGSLLVDVFSEAGVNDDGFLRDLEPPTESSDSLLAEGPGDSDSAPPSAV 732
            ||.|       |||  .||         |.|.:..|.|          :|.:..|.:.:...|||
  Fly   678 GLST-------PPSNNIGS---------GSNSNSTLID----------VLGDMYGSNSNNNSSAV 716

Zfish   733 SEDAAPPLPESNELLNKFVCKNNGVLFENQLLQIGIKSEYRQNLGRMYLFYGNKTSVQFVTFTTT 797
            ..            ..||:.|||||||||::||||:|||:||||||:.|||||||.|....|...
  Fly   717 YN------------TKKFLFKNNGVLFENEMLQIGVKSEFRQNLGRLGLFYGNKTQVPLTNFNPV 769

Zfish   798 VSCPGELQSQLNVQAKPVEPLIEGGAQVQQVINIECLGDFCEAPLLNIKFRYGGALQNLSLKLPV 862
            :....|...:||||.|.|||.:|.|||:||::..||:.|:.:||.:.|.|||.|..|..|:|||:
  Fly   770 LQWSAEDALKLNVQMKVVEPTLEAGAQIQQLLTAECIEDYADAPTIEISFRYNGTQQKFSIKLPL 834

Zfish   863 TINKFFQPTEMASHDFFQRWKQLSQPQQEAQKIFKASHAMDTEVIKAKLLGLGMALLENVDPNPE 927
            ::||||:||||.:..||.|||.||..||.:||:|||:..:|....:.||:|.||.||:.|||||:
  Fly   835 SVNKFFEPTEMNAESFFARWKNLSGEQQRSQKVFKAAQPLDLPGARNKLMGFGMQLLDQVDPNPD 899

Zfish   928 NFVCAGVIQTKAQQVGSLLRLEPNAQAQSGEQMYRLTLRSSKDTVSKRLCELLAEQF 984
            |.||||:|.|::||||.|:|||||.||    ||:|||:|:||:||::.:|:||.:||
  Fly   900 NMVCAGIIHTQSQQVGCLMRLEPNKQA----QMFRLTVRASKETVTREICDLLTDQF 952

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ap2a1	XP_009297842.1	Adaptin_N	29..591	CDD:279882	452/562 (80%)
		RIX1	141..>292	CDD:285390	109/151 (72%)
		Alpha_adaptinC2	758..861	CDD:197886	54/102 (53%)
		Alpha_adaptin_C	867..979	CDD:280460	63/111 (57%)
AP-2alpha	NP_995607.1	Adaptin_N	40..598	CDD:279882	450/557 (81%)
		Alpha_adaptinC2	730..839	CDD:197886	57/108 (53%)
		Alpha_adaptin_C	839..947	CDD:280460	63/111 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590483
Domainoid	1	1.000	894	1.000	Domainoid score	I51
eggNOG	1	0.900	-	-		E1_COG4354
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1282	1.000	Inparanoid score	I161
OMA	1	1.010	-	-		QHG53727
OrthoDB	1	1.010	-	-		D751651at2759
OrthoFinder	1	1.000	-	-		FOG0002465
OrthoInspector	1	1.000	-	-		oto40659
orthoMCL	1	0.900	-	-		OOG6_101447
Panther	1	1.100	-	-	O	PTHR22780
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1882
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	13	12.810