Protein Alignment PRKCE and PKC1

DIOPT Version :10

• Sequence 1: NP_005391.1
• Gene: PRKCE / 5581
• HGNCID: 9401
• Length: 737
• Species: Homo sapiens
• Sequence 2: NP_009445.2
• Gene: PKC1 / 852169
• SGDID: S000000201
• Length: 1151
• Species: Saccharomyces cerevisiae
• Alignment Length: 986
• Identity: 270/986 - (27%)
• Similarity: 419/986 - (42%)
• Gaps: 301/986 - (30%)

Human     6 GLLKIKICEAVSLKPTAWSLRHAVGP----RPQTFLLDPYIALNVDDSRIGQTATKQKTNSPAWH 66
            |:|.|.|       ..|..:.|...|    :|::     |:.:.:||:.  :..||...|. .|.
Yeast   209 GVLTIGI-------TAARDVDHIQSPMFARKPES-----YVTIKIDDTI--KARTKPSRND-RWS 258

Human    67 DEFVTDVCNGRKIELAVFHDAPIGYDDFVANCTIQF-------EELLQ----------------- 107
            ::|...|..|.:||:.|:...    :|.:....|.:       ||:.:
Yeast   259 EDFQIPVEKGNEIEITVYDKV----NDSLIPVAIMWLLLSDIAEEIRKKKAGQTNEQQGWVNASN 319

Human   108 -NGSRHF-------------------------------------EDWIDLEPEGRVYVIIDLSGS 134
             ||....                                     ..|..|||.|::.:.:....|
Yeast   320 INGGSSLASEEGSTLTSTYSNSAIQSTSAKNVQGENTSTSQISTNSWFVLEPSGQILLTLGFHKS 384

Human   135 SGEAPKDNEERVFRERMRPRKRQGAVRRRVHQV---NGHKFMATYLRQPTYCSHCRDFIWGVIGK 196
            |      ..||  ::.|....|.||:..|..::   :||.|:.........|::|.||    :..
Yeast   385 S------QIER--KQLMGGLHRHGAIINRKEEIFEQHGHHFVQKSFYNIMCCAYCGDF----LRY 437

Human   197 QGYQCQVCTCVVHKRCHELIITKCAGLKKQET-PDQVGSQRFSVNMPHKFGIHNYKVPT------ 254
            .|:|||.|..:.||:|:..::|||......:| ||:.   :.:..:||:|      :||
Yeast   438 TGFQCQDCKFLCHKKCYTNVVTKCIAKTSTDTDPDEA---KLNHRIPHRF------LPTSNRGTK 493

Human   255 FCDHCGSLL-WGLLRQGLQCKVCKMNVHRRCETNVAPNCGVDARGIAKVL--------------- 303
            :|.|||.:| || ..:..:|..|.:..|.:|...|...||:......|:|
Yeast   494 WCCHCGYILPWG-RHKVRKCSECGIMCHAQCAHLVPDFCGMSMEMANKILKTIQDTKRNQEKKKR 557

Human   304 ----ADLGVTPDKITNSGQRRKKLIAGAESPQPAS----GSSPSEEDRSKSAPT----------- 349
                |.||.:......|.....||...|.:|.|..    ..:||.:...:.:||
Yeast   558 TVPSAQLGSSIGTANGSDLSPSKLAERANAPLPPQPRKHDKTPSPQKVGRDSPTKQHDPIIDKRI 622

Human   350 ----------------------------------SP----------------------------- 351
                                              ||
Yeast   623 SLQTHGREKLNKFIDENEAYLNFTEGAQQTAEFSSPEKTLDPTSNRRSLGLTDLSIEHSQTWESK 687

Human   352 ------------------------------CDQEIKELENNIRKALSFDNRGEEHRAASSPDGQL 386
                                          .|.|:..::...::.|.::|:.:...|..:.|...
Yeast   688 DDLMRDELELWKAQREEMELEIKQDSGEIQEDLEVDHIDLETKQKLDWENKNDFREADLTIDSTH 752

Human   387 MSP-----GENGEVRQGQA---------------------------------------------K 401
            .:|     .|..::.|..|                                             :
Yeast   753 TNPFRDMNSETFQIEQDHASKEVLQETVSLAPTSTHASRTTDQQSPQKSQTSTSAKHKKRAAKRR 817

Human   402 RLGLDEFNFIKVLGKGSFGKVMLAELKGKDEVYAVKVLKKDVILQDDDVDCTMTEKRILALA--R 464
            ::.||.|..:||||||:||||:|::.|..|.:.|:||||||.|:|:.|::....||::..||  .
Yeast   818 KVSLDNFVLLKVLGKGNFGKVILSKSKNTDRLCAIKVLKKDNIIQNHDIESARAEKKVFLLATKT 882

Human   465 KHPYLTQLYCCFQTKDRLFFVMEYVNGGDLMFQIQRSRKFDEPRSRFYAAEVTSALMFLHQHGVI 529
            |||:||.|||.|||::|::|.||::.|||||:.:|..| ....|::||||||..||.:.|.:|||
Yeast   883 KHPFLTNLYCSFQTENRIYFAMEFIGGGDLMWHVQNQR-LSVRRAKFYAAEVLLALKYFHDNGVI 946

Human   530 YRDLKLDNILLDAEGHCKLADFGMCKEGILNGVTTTTFCGTPDYIAPEILQELEYGPSVDWWALG 594
            ||||||:||||..|||.|:||:|:||:.:..|..|:||||||:::|||||:|.||..:|||||.|
Yeast   947 YRDLKLENILLTPEGHIKIADYGLCKDEMWYGNRTSTFCGTPEFMAPEILKEQEYTKAVDWWAFG 1011

Human   595 VLMYEMMAGQPPFEADNEDDLFESILHDDVLYPVWLSKEAVSILKAFMTKNPHKRLGCVASQNGE 659
            ||:|:|:..|.||..|:||::|.:||.|:.|||:.::.|.|.|.:..:||:|.||||  |.....
Yeast  1012 VLLYQMLLCQSPFSGDDEDEVFNAILTDEPLYPIDMAGEIVQIFQGLLTKDPEKRLG--AGPRDA 1074

Human   660 DAIKQHPFFKEIDWVLLEQKKIKPPFKPRIKTKRDVNNFDQDFTREEPVLTLVDEAIVKQINQEE 724
            |.:.:.|||:.|::..:...::|||:.|.||:..|.:.|:|:||...|.||.: .:::....|||
Yeast  1075 DEVMEEPFFRNINFDDILNLRVKPPYIPEIKSPEDTSYFEQEFTSAPPTLTPL-PSVLTTSQQEE 1138

Human   725 FKGFSYFGEDL 735
            |:|||:..:||
Yeast  1139 FRGFSFMPDDL 1149

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PRKCE	NP_005391.1	C2_PKC_epsilon	3..135	CDD:175981	32/194 (16%)
		C1_nPKC_epsilon-like_rpt1	161..224	CDD:410385	19/65 (29%)
		Interaction with actin. /evidence=ECO:0000250	223..228		0/4 (0%)
		C1_nPKC_epsilon-like_rpt2	241..295	CDD:410388	19/60 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	325..356		10/138 (7%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	370..398		5/32 (16%)
		STKc_nPKC_epsilon	412..732	CDD:270743	157/321 (49%)
PKC1	NP_009445.2	HR1_PKC-like_1_fungi	1..72	CDD:212011
		HR1_PKC-like_2_fungi	110..181	CDD:212010
		C2_fungal_Pkc1p	211..319	CDD:176071	24/126 (19%)
		C1_ScPKC1-like_rpt1	413..464	CDD:410372	18/54 (33%)
		C1_ScPKC1-like_rpt2	478..536	CDD:410373	19/64 (30%)
		STKc_PKC	828..1145	CDD:270722	157/320 (49%)