DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PRKCE and PKC1

DIOPT Version :9

Sequence 1:	NP_005391.1	Gene:	PRKCE / 5581	HGNCID:	9401	Length:	737	Species:	Homo sapiens
Sequence 2:	NP_009445.2	Gene:	PKC1 / 852169	SGDID:	S000000201	Length:	1151	Species:	Saccharomyces cerevisiae

Alignment Length:	986	Identity:	270/986 - (27%)
Similarity:	419/986 - (42%)	Gaps:	301/986 - (30%)

- Green bases have known domain annotations that are detailed below.

Human     6 GLLKIKICEAVSLKPTAWSLRHAVGP----RPQTFLLDPYIALNVDDSRIGQTATKQKTNSPAWH 66
            |:|.|.|       ..|..:.|...|    :|::     |:.:.:||:.  :..||...|. .|.
Yeast   209 GVLTIGI-------TAARDVDHIQSPMFARKPES-----YVTIKIDDTI--KARTKPSRND-RWS 258

Human    67 DEFVTDVCNGRKIELAVFHDAPIGYDDFVANCTIQF-------EELLQ----------------- 107
            ::|...|..|.:||:.|:...    :|.:....|.:       ||:.:
Yeast   259 EDFQIPVEKGNEIEITVYDKV----NDSLIPVAIMWLLLSDIAEEIRKKKAGQTNEQQGWVNASN 319

Human   108 -NGSRHF-------------------------------------EDWIDLEPEGRVYVIIDLSGS 134
             ||....                                     ..|..|||.|::.:.:....|
Yeast   320 INGGSSLASEEGSTLTSTYSNSAIQSTSAKNVQGENTSTSQISTNSWFVLEPSGQILLTLGFHKS 384

Human   135 SGEAPKDNEERVFRERMRPRKRQGAVRRRVHQV---NGHKFMATYLRQPTYCSHCRDFIWGVIGK 196
            |      ..||  ::.|....|.||:..|..::   :||.|:.........|::|.||    :..
Yeast   385 S------QIER--KQLMGGLHRHGAIINRKEEIFEQHGHHFVQKSFYNIMCCAYCGDF----LRY 437

Human   197 QGYQCQVCTCVVHKRCHELIITKCAGLKKQET-PDQVGSQRFSVNMPHKFGIHNYKVPT------ 254
            .|:|||.|..:.||:|:..::|||......:| ||:.   :.:..:||:|      :||
Yeast   438 TGFQCQDCKFLCHKKCYTNVVTKCIAKTSTDTDPDEA---KLNHRIPHRF------LPTSNRGTK 493

Human   255 FCDHCGSLL-WGLLRQGLQCKVCKMNVHRRCETNVAPNCGVDARGIAKVL--------------- 303
            :|.|||.:| || ..:..:|..|.:..|.:|...|...||:......|:|
Yeast   494 WCCHCGYILPWG-RHKVRKCSECGIMCHAQCAHLVPDFCGMSMEMANKILKTIQDTKRNQEKKKR 557

Human   304 ----ADLGVTPDKITNSGQRRKKLIAGAESPQPAS----GSSPSEEDRSKSAPT----------- 349
                |.||.:......|.....||...|.:|.|..    ..:||.:...:.:||
Yeast   558 TVPSAQLGSSIGTANGSDLSPSKLAERANAPLPPQPRKHDKTPSPQKVGRDSPTKQHDPIIDKRI 622

Human   350 ----------------------------------SP----------------------------- 351
                                              ||
Yeast   623 SLQTHGREKLNKFIDENEAYLNFTEGAQQTAEFSSPEKTLDPTSNRRSLGLTDLSIEHSQTWESK 687

Human   352 ------------------------------CDQEIKELENNIRKALSFDNRGEEHRAASSPDGQL 386
                                          .|.|:..::...::.|.::|:.:...|..:.|...
Yeast   688 DDLMRDELELWKAQREEMELEIKQDSGEIQEDLEVDHIDLETKQKLDWENKNDFREADLTIDSTH 752

Human   387 MSP-----GENGEVRQGQA---------------------------------------------K 401
            .:|     .|..::.|..|                                             :
Yeast   753 TNPFRDMNSETFQIEQDHASKEVLQETVSLAPTSTHASRTTDQQSPQKSQTSTSAKHKKRAAKRR 817

Human   402 RLGLDEFNFIKVLGKGSFGKVMLAELKGKDEVYAVKVLKKDVILQDDDVDCTMTEKRILALA--R 464
            ::.||.|..:||||||:||||:|::.|..|.:.|:||||||.|:|:.|::....||::..||  .
Yeast   818 KVSLDNFVLLKVLGKGNFGKVILSKSKNTDRLCAIKVLKKDNIIQNHDIESARAEKKVFLLATKT 882

Human   465 KHPYLTQLYCCFQTKDRLFFVMEYVNGGDLMFQIQRSRKFDEPRSRFYAAEVTSALMFLHQHGVI 529
            |||:||.|||.|||::|::|.||::.|||||:.:|..| ....|::||||||..||.:.|.:|||
Yeast   883 KHPFLTNLYCSFQTENRIYFAMEFIGGGDLMWHVQNQR-LSVRRAKFYAAEVLLALKYFHDNGVI 946

Human   530 YRDLKLDNILLDAEGHCKLADFGMCKEGILNGVTTTTFCGTPDYIAPEILQELEYGPSVDWWALG 594
            ||||||:||||..|||.|:||:|:||:.:..|..|:||||||:::|||||:|.||..:|||||.|
Yeast   947 YRDLKLENILLTPEGHIKIADYGLCKDEMWYGNRTSTFCGTPEFMAPEILKEQEYTKAVDWWAFG 1011

Human   595 VLMYEMMAGQPPFEADNEDDLFESILHDDVLYPVWLSKEAVSILKAFMTKNPHKRLGCVASQNGE 659
            ||:|:|:..|.||..|:||::|.:||.|:.|||:.::.|.|.|.:..:||:|.||||  |.....
Yeast  1012 VLLYQMLLCQSPFSGDDEDEVFNAILTDEPLYPIDMAGEIVQIFQGLLTKDPEKRLG--AGPRDA 1074

Human   660 DAIKQHPFFKEIDWVLLEQKKIKPPFKPRIKTKRDVNNFDQDFTREEPVLTLVDEAIVKQINQEE 724
            |.:.:.|||:.|::..:...::|||:.|.||:..|.:.|:|:||...|.||.: .:::....|||
Yeast  1075 DEVMEEPFFRNINFDDILNLRVKPPYIPEIKSPEDTSYFEQEFTSAPPTLTPL-PSVLTTSQQEE 1138

Human   725 FKGFSYFGEDL 735
            |:|||:..:||
Yeast  1139 FRGFSFMPDDL 1149

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PRKCE	NP_005391.1	C2_PKC_epsilon	3..135	CDD:175981	32/194 (16%)
		C1_nPKC_epsilon-like_rpt1	161..224	CDD:410385	19/65 (29%)
		Interaction with actin. /evidence=ECO:0000250	223..228		0/4 (0%)
		C1_nPKC_epsilon-like_rpt2	241..295	CDD:410388	19/60 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	325..356		10/138 (7%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	370..398		5/32 (16%)
		STKc_nPKC_epsilon	412..732	CDD:270743	157/321 (49%)
PKC1	NP_009445.2	HR1_PKC-like_1_fungi	1..72	CDD:212011
		HR1_PKC-like_2_fungi	110..181	CDD:212010
		C2_fungal_Pkc1p	211..319	CDD:176071	24/126 (19%)
		C1_ScPKC1-like_rpt1	413..464	CDD:410372	18/54 (33%)
		C1_ScPKC1-like_rpt2	478..536	CDD:410373	19/64 (30%)
		STKc_PKC	828..1145	CDD:270722	157/320 (49%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0694
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H48343
Inparanoid	1	1.050	427	1.000	Inparanoid score	I319
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000117
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_102972
Panther	1	1.100	-	-	O	PTHR24356
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R891
SonicParanoid	1	1.000	-	-		X125
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.890