DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PRKCE and Pkcdelta

DIOPT Version :9

Sequence 1:	NP_005391.1	Gene:	PRKCE / 5581	HGNCID:	9401	Length:	737	Species:	Homo sapiens
Sequence 2:	NP_572797.3	Gene:	Pkcdelta / 32191	FlyBaseID:	FBgn0259680	Length:	1894	Species:	Drosophila melanogaster

Alignment Length:	435	Identity:	202/435 - (46%)
Similarity:	274/435 - (62%)	Gaps:	38/435 - (8%)

- Green bases have known domain annotations that are detailed below.

Human   311 DKITNSGQRRKKLIAGAESPQPASGSSPSEEDRSKSAPT----SPCDQEIKELENNIRKALSFDN 371
            |...:||..     ||..| .|::||.......:.|:|:    |.|               |.|:
  Fly  1475 DSSNSSGSN-----AGTLS-VPSAGSGSGGGASTSSSPSIIRMSTC---------------SNDS 1518

Human   372 RGEEHRAASSPDGQLMSPGENGEVRQG-----------QAKRLGLDEFNFIKVLGKGSFGKVMLA 425
            ..|...|.|||...|.:.....:.::.           :.|...:|:|:|:.||||||||||:||
  Fly  1519 GFEGGTAPSSPKKMLETSYTYSQFQKSGRFTAPATVIPRFKNYSVDDFHFLAVLGKGSFGKVLLA 1583

Human   426 ELKGKDEVYAVKVLKKDVILQDDDVDCTMTEKRILALARKHPYLTQLYCCFQTKDRLFFVMEYVN 490
            ||:.....||:|.|||||:|:|||||.|:.|:::|||..|||||..|:|.|||:..|||||||:|
  Fly  1584 ELRDTTYYYAIKCLKKDVVLEDDDVDSTLIERKVLALGTKHPYLCHLFCTFQTESHLFFVMEYLN 1648

Human   491 GGDLMFQIQRSRKFDEPRSRFYAAEVTSALMFLHQHGVIYRDLKLDNILLDAEGHCKLADFGMCK 555
            ||||||.||.|.:|.|.|:|||.||:.|.|.|||:.|:|||||||||:|||.|||.::|||||||
  Fly  1649 GGDLMFHIQESGRFSEERARFYGAEIISGLKFLHKKGIIYRDLKLDNVLLDYEGHVRIADFGMCK 1713

Human   556 EGILNGVTTTTFCGTPDYIAPEILQELEYGPSVDWWALGVLMYEMMAGQPPFEADNEDDLFESIL 620
            ..|....|..:|||||||:||||::..:|..:||||:.|||:|||:.||.||...:||:||.||.
  Fly  1714 LQIYLDKTADSFCGTPDYMAPEIIKGEKYNQNVDWWSFGVLLYEMLIGQSPFSGCDEDELFWSIC 1778

Human   621 HDDVLYPVWLSKEAVSILKAFMTKNPHKRLGCVASQNGEDAIKQHPFFKEIDWVLLEQKKIKPPF 685
            ::...:||::|.||..|||..:.|:..||:|...|..|:  |..|.||:.|||.|||:::|:|||
  Fly  1779 NEIPWFPVYISAEATGILKGLLEKDYTKRIGSQYSPAGD--IADHIFFRPIDWGLLEKRQIEPPF 1841

Human   686 KPRIKTKRDVNNFDQDFTREEPVLTLVDEAIVKQINQEEFKGFSY 730
            ||::|...|...||:.||||...||.:|:.|:..::|::|.||:|
  Fly  1842 KPQVKHPLDTQYFDRVFTRERVRLTPIDKEILASMDQKQFHGFTY 1886

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PRKCE	NP_005391.1	C2_PKC_epsilon	3..135	CDD:175981
		C1_nPKC_epsilon-like_rpt1	161..224	CDD:410385
		Interaction with actin. /evidence=ECO:0000250	223..228
		C1_nPKC_epsilon-like_rpt2	241..295	CDD:410388
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	325..356		10/34 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	370..398		7/27 (26%)
		STKc_nPKC_epsilon	412..732	CDD:270743	177/319 (55%)
Pkcdelta	NP_572797.3	S_TKc	1566..1824	CDD:214567	148/259 (57%)
Pkcdelta	NP_572797.3	STKc_nPKC_theta_like	1570..1889	CDD:270744	177/319 (55%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149251
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D222529at2759
OrthoFinder	1	1.000	-	-		FOG0000117
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R891
SonicParanoid	1	1.000	-	-		X125
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.880