Protein Alignment PRKCD and tpa-1

DIOPT Version :9

• Sequence 1: NP_001341605.1
• Gene: PRKCD / 5580
• HGNCID: 9399
• Length: 695
• Species: Homo sapiens
• Sequence 2: NP_001379590.1
• Gene: tpa-1 / 176825
• WormBaseID: WBGene00006599
• Length: 704
• Species: Caenorhabditis elegans
• Alignment Length: 684
• Identity: 328/684 - (47%)
• Similarity: 453/684 - (66%)
• Gaps: 51/684 - (7%)

Human    44 QPFCAVKMKEALSTERGKTLVQKKPTMYPEWKSTFDAHIYEGRVIQIVLMRAAEEPVSEVTVGVS 108
            ||  ||.:||.:.......|||||.|:||||:..:|..:.|||::||||| ..:.||.|.|:.:.
 Worm    32 QP--AVNVKEKIEVNGESRLVQKKKTLYPEWEKCWDTAVAEGRILQIVLM-FNQTPVVEATMRLE 93

Human   109 VLAERCKKNNGKAEFWLDLQPQAKVLMSVQYF---------LEDVDCKQSMRSEDEAKFPTMNRR 164
            .:..:| |::.....|::.:|..::|...::.         :||:     |.|...:......||
 Worm    94 DIISKC-KSDAITHIWINTKPNGRILAQTRHLKNAPDDDHPVEDI-----MTSRSNSGPGIQRRR 152

Human   165 GAIKQAKIHYIKNHEFIATFFGQPTFCSVCKDFVWGLNKQGYKCRQCNAAIHKKCIDKIIGRCTG 229
            ||||.|::|.|:.|:|:||||.||.|||:|.||:||||||||:|:.|:||:||||.:|:|.:|.|
 Worm   153 GAIKHARVHEIRGHQFVATFFRQPHFCSLCSDFMWGLNKQGYQCQLCSAAVHKKCHEKVIMQCPG 217

Human   230 TAANSRDTIFQKERFNIDMPHRFKVHNYMSPTFCDHCGSLLWGLVKQGLKCEDCGMNVHHKCREK 294
            :|.|:::|:..||||.:|:|||||.:|:.||||||||||:|:||.||||:||.|.:..||||...
 Worm   218 SAKNTKETMALKERFKVDIPHRFKTYNFKSPTFCDHCGSMLYGLFKQGLRCEVCNVACHHKCERL 282

Human   295 VANLCGINQKLLAEALNQVTQ-------------------RASRRSDSASSEPVGIYQGFEKKTG 340
            ::||||:|||.|:|..:::.:                   ..|:.:.|..::...:::..:...
 Worm   283 MSNLCGVNQKQLSEMYHEIKRGTHATASCPPNIANLHLNGETSKNNGSLPNKLKNLFKSHQYSV- 346

Human   341 VAGEDMQDNSGTYGKIWEGS----SKCNINNFIFHKVLGKGSFGKVLLGELKGRGEYFAIKALKK 401
               |:.::.......||.|.    .|..:.:|...|||||||||||:|.||||:.|::|:|.|||
 Worm   347 ---EEQKETDEYMDNIWGGGDGPVKKFALPHFNLLKVLGKGSFGKVMLVELKGKNEFYAMKCLKK 408

Human   402 DVVLIDDDVECTMVEKRVLTLAAENPFLTHLICTFQTKDHLFFVMEFLNGGDLMYHIQDKGRFEL 466
            ||:|.|||.|||.:|:|||.||::.|||..|.|:|||.::||||||:|||||||:|||...:|:.
 Worm   409 DVILEDDDTECTYIERRVLILASQCPFLCQLFCSFQTNEYLFFVMEYLNGGDLMHHIQQIKKFDE 473

Human   467 YRATFYAAEIMCGLQFLHSKGIIYRDLKLDNVLLDRDGHIKIADFGMCKENIFGES-RASTFCGT 530
            .|..|||.||:..|||||:..||||||||||||||.|||||:|||||.|..:..|: .|||||||
 Worm   474 ARTRFYACEIVVALQFLHTNNIIYRDLKLDNVLLDCDGHIKLADFGMAKTEMNRENGMASTFCGT 538

Human   531 PDYIAPEILQGLKYTFSVDWWSFGVLLYEMLIGQSPFHGDDEDELFESIRVDTPHYPRWITKESK 595
            ||||:|||::|..|..:||:||||||:||||:|||||||:.|||||:||..:.|::|:.|:||:.
 Worm   539 PDYISPEIIKGQLYNEAVDFWSFGVLMYEMLVGQSPFHGEGEDELFDSILNERPYFPKTISKEAA 603

Human   596 DILEKLFEREPTKRLGV----TGNIKIHPFFKTINWTLLEKRRLEPPFRPKVKSPRDYSNFDQEF 656
            ..|..||:|.|..|||:    .|.|:.|.||:.::|...|.|::.|||:|.:||..|.||||.:|
 Worm   604 KCLSALFDRNPNTRLGMPECPDGPIRQHCFFRGVDWKRFENRQVPPPFKPNIKSNSDASNFDDDF 668

Human   657 LNEKARLS-YSDKNLIDSMDQSAFAGFSFVNPKF 689
            .||||.|: ..||||:.|:|..||..||:.||.|
 Worm   669 TNEKAALTPVHDKNLLASIDPEAFLNFSYTNPHF 702

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PRKCD	NP_001341605.1	C1_1	178..227	CDD:278556	32/48 (67%)
		C1_1	250..302	CDD:278556	33/51 (65%)
		STKc_nPKC_delta	372..687	CDD:173710	189/320 (59%)
tpa-1	NP_001379590.1	C1_nPKC_theta-like_rpt1	159..219	CDD:410384	36/59 (61%)
		C1_nPKC_theta-like_rpt2	238..287	CDD:410387	30/48 (63%)
		STKc_nPKC_theta_like	379..700	CDD:270744	189/320 (59%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	87	1.000	Domainoid score	I5583
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55963
Inparanoid	1	1.050	656	1.000	Inparanoid score	I456
Isobase	1	0.950	-	0	Normalized mean entropy	S1312
OMA	1	1.010	-	-		QHG45425
OrthoDB	1	1.010	-	-		D222529at2759
OrthoFinder	1	1.000	-	-		FOG0000117
OrthoInspector	1	1.000	-	-		otm15904
orthoMCL	1	0.900	-	-		OOG6_105998
Panther	1	1.100	-	-	LDO	PTHR24356
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R891
SonicParanoid	1	1.000	-	-		X125
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	15	14.960