DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AXL and Eph

DIOPT Version :9

Sequence 1:	NP_068713.2	Gene:	AXL / 558	HGNCID:	905	Length:	894	Species:	Homo sapiens
Sequence 2:	NP_524625.3	Gene:	Eph / 43803	FlyBaseID:	FBgn0025936	Length:	1096	Species:	Drosophila melanogaster

Alignment Length:	928	Identity:	227/928 - (24%)
Similarity:	354/928 - (38%)	Gaps:	236/928 - (25%)

- Green bases have known domain annotations that are detailed below.

Human    41 PGNITGARGLTGTLRCQLQ-VQGEPPEVHWLRDGQILELADSTQTQVPLGE---DEQDDWIVVSQ 101
            |||....:.....|..:.. ...|||.  |..|...|      ..::..||   ::..|  |...
  Fly   171 PGNALSCKETFSLLFYEFDAATREPPP--WQTDSYRL------IARIAAGEGRFNQNSD--VDIN 225

Human   102 LRITSLQLSDTGQY-------QCLVFLGHQT-FVSQPGYVGLEGLPYFLEEPEDRTVAA------ 152
            ..:.|:.::..|.|       .|:..|..:. :::.|...  |...:|.|.|..|.:..
  Fly   226 TEVKSIAVNKKGVYFAFRDQGACISVLAVKVYYITCPAVT--ENFAHFNETPTGREITIIEKQNG 288

Human   153 ---------NTPFNL------------SCQAQGPPEPVDLLWLQDAVPLATAPGHGPQRSLHVP- 195
                     .||..|            .|:.:...||..........||.|.  ..|:.:...|
  Fly   289 TCVDNAEPYETPTYLCKGDGKWTILTGGCRCKAGYEPNYTNKTCTECPLGTF--KSPEVTKCTPC 351

Human   196 ----GLNKTSSFSCEAHNAKGV----TTSRTATITVLPQQPRNLHLVSRQPTELEVAWTPGLSGI 252
                ..:||.|..|:.  |.|.    ...|.......|..|.||.|:....|...::|:......
  Fly   352 PPNSNASKTGSPFCKC--ASGFYRHPNDGRHMPCYSPPAAPTNLTLLFVDQTSAIISWSAPAKNE 414

Human   253 YPLTHCTLQAVLSDDGMGIQAG--EPDPPEEPLTSQASVPPHQLRLGSLHPHTPYHIRVACTSS- 314
            ...:....:...||....|:..  .|:....|.|.  :....::.|.:|.|.|.|.:::...:|
  Fly   415 SFSSETNSKIYHSDIVYKIKCNICSPNVVYNPSTD--TFNETKITLTNLEPVTTYTVQIHAINSV 477

Human   315 ---------QGPSSWTHW------------LPVETPEGVPLGPPENISATRN------------- 345
                     ...||....            :|::..| |..|..|.:..|.:
  Fly   478 SHINEFKRHSNESSLVAVSDIVFSNTSLLNIPLDLNE-VKTGQAEIVFTTESVLLSTVFNLRILA 541

Human   346 --GSQAFVHWQEP---RAPLQGTLLGYRLAYQGQDTPEVLMD----------------IGLRQEV 389
              ...|.:.|.:|   ..||:        .|:.:..|:|.:|                :||.:..
  Fly   542 ITNKDADLEWDKPVQSDFPLE--------FYEVRWFPKVELDAINKSALNTKETKAHIVGLLENT 598

Human   390 TLELQ-------GDGSVSNLTVCVAAYTAAGDGPWSLPVPLEAWRPGQAQPVHQLVKEPSTPAFS 447
            ....|       |.||.||:   :.|.|                    .|.|..:..:.....|
  Fly   599 EYGFQVRCKTNNGFGSYSNM---IYAQT--------------------LQSVGSVYDDSVQIRF- 639

Human   448 WPWWYVLLGAVVAAACVLILALFLV---------HR---RKKETRY---------GEV----FEP 487
                  :.||:|..  ||.|.:|::         |:   .||.|.:         .||    ..|
  Fly   640 ------IAGAIVTG--VLFLVIFIIATVYFMRSKHQDDLDKKSTNHLPLPLDYASNEVNSMDTTP 696

Human   488 TVERGELVVR---YRVRKSYSRRTTEATLNSLGISEELKEKLRDVMVDRHKVALGKTLGEGEFGA 549
            .|::..|.|.   :...:||....|....|     :.::|..|:  :|.:.:.:...:|.||||.
  Fly   697 IVKKLHLNVTTPLFGNSRSYVDPHTYEDPN-----QAIREFARE--IDANYITIEAIIGGGEFGD 754

Human   550 VMEGQLN------QDDSILKVAVKTMKIAICTRSELEDFLSEAVCMKEFDHPNVMRLIGVCFQGS 608
            |..|:|.      ||   :.||:||:|.....::.. |||:||..|.:||||||:.|.||..:.:
  Fly   755 VCRGRLKIPPNFVQD---IDVAIKTLKPGSSEKARC-DFLTEASIMGQFDHPNVIYLQGVVTRSN 815

Human   609 ERESFPAPVVIL-PFMKHGDLHSFLLYSRLGDQPVYLPTQMLVKFMADIASGMEYLSTKRFIHRD 672
                   ||:|: .:|::|.|.:||   |:.|..  ..|..|:..:..|||||.|||...::|||
  Fly   816 -------PVMIITEYMENGSLDTFL---RVNDGK--FQTLQLIVMLRGIASGMSYLSDMNYVHRD 868

Human   673 LAARNCMLNENMSVCVADFGLSKKIYNGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWSFGV 737
            |||||.::|..:...:||||||::|.|.......|..|:||:|.|.|::|.|.:||.|||||:||
  Fly   869 LAARNVLVNAQLICKIADFGLSREIENASDAYTTRGGKIPVRWTAPEAIAFRKFTSASDVWSYGV 933

Human   738 TMWEIATRGQTPYPGVENSEIYDYLRQGNRLKQPADCLDGLYALMSRCWELNPQDRPSFTELRED 802
            .:||:.:.|:.||....|.::...:.:|.||..|.||.:.||.||..||:.....||:|..:...
  Fly   934 VLWEVMSYGERPYWNWSNQDVIKSIEKGYRLPAPMDCPEALYQLMLDCWQKQRTHRPTFASIVST 998

Human   803 LENTLKALPPAQEPDEIL 820
            |:|.      |::|..:|
  Fly   999 LDNL------ARQPQSLL 1010

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AXL	NP_068713.2	interaction with Gas6	26..92		12/54 (22%)
		Ig	53..119	CDD:319273	15/76 (20%)
		Ig2_Axl_Tyro3_like	141..222	CDD:143226	22/116 (19%)
		FN3	225..328	CDD:238020	22/126 (17%)
		fn3	335..418	CDD:306538	22/123 (18%)
		PTKc_Axl	535..811	CDD:270660	108/282 (38%)
Eph	NP_524625.3	EphR_LBD	85..260	CDD:198439	19/98 (19%)
		FN3	387..476	CDD:238020	18/90 (20%)
		FN3	536..623	CDD:238020	18/97 (19%)
		EphA2_TM	644..736	CDD:291255	21/100 (21%)
		PTKc_EphR	736..1002	CDD:270629	108/281 (38%)
		Pkinase_Tyr	741..999	CDD:285015	106/273 (39%)
		SAM_1	1033..1092	CDD:278937
		SAM	1039..1092	CDD:197735
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910