DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment AXL and ed

DIOPT Version :9

Sequence 1:NP_068713.2 Gene:AXL / 558 HGNCID:905 Length:894 Species:Homo sapiens
Sequence 2:NP_001260013.1 Gene:ed / 33619 FlyBaseID:FBgn0000547 Length:1332 Species:Drosophila melanogaster


Alignment Length:712 Identity:144/712 - (20%)
Similarity:234/712 - (32%) Gaps:236/712 - (33%)


- Green bases have known domain annotations that are detailed below.


Human    22 WACMAPRGTQA---EESPFVGN----------PGN--ITGAR-----GLTGTLRCQLQVQGEP-P 65
            :.|.|....|:   |.|..|||          ||.  ||..:     |...||.|.....|.| |
  Fly   400 YICRAVNIMQSQGMERSERVGNSTVALLVRHRPGQAYITPNKPVVHVGNGVTLTCSANPPGWPVP 464

Human    66 EVHWLR--DGQILELADSTQTQVPLGEDEQDDWIVVSQLRITSLQLSDTGQYQC----------- 117
            :..|.|  ||:.    .|||..:..|          .|..|....|.:.|:|.|           
  Fly   465 QYRWFRDMDGEF----SSTQKILAQG----------PQYSIPKAHLGNEGKYHCHAVNELGIGMM 515

Human   118 --LVFLGHQTFVSQPGYVGLEGLPYFLEEPEDRTV--AANTPFNLSCQAQGPPEPVDLLWLQDAV 178
              :|...||.             |.||.:.:....  .|:|.:.::|.|:|.|.| .:.||:|||
  Fly   516 ATIVLEIHQP-------------PQFLAKLQQHMTRRVADTDYTVTCSAKGKPAP-SVKWLKDAV 566

Human   179 PL---------ATAPGHG------------------PQRSLHVPGLNKTSSFSCEAHNAKGVTTS 216
            .:         .|.|..|                  |..:..|||  ....::|...|.  |.::
  Fly   567 EILPEENLYEVQTNPDQGLNGMVTVQSQLKFRGKARPNGNALVPG--DRGLYTCLYQNE--VNSA 627

Human   217 RTATITVLPQQPRNLHLVS------RQPTEL----------EVAWTPGLSGIYPLTHCTLQAVLS 265
            .::....:..:|..||..:      |:..|:          |..|..| :...|||       :|
  Fly   628 NSSMQLRIEHEPIVLHQYNKVAFDIRETAEVVCKVQAYPKPEFQWQFG-NNPSPLT-------MS 684

Human   266 DDGMGIQAGEPDPPEEPLTSQASVPPHQLRLGSL--HPHTPYHIRVACTSSQGPSSWTHWLPVET 328
            .||        .......|....:....|::.||  ..:..|..|||.|..      |...|:..
  Fly   685 SDG--------HYEISTTTDNNDIYTSVLKINSLTHSDYGEYTCRVANTLD------TIRAPIRL 735

Human   329 PEGVPLGPPENISATRNG------------------SQAFVHWQEPRAPLQ-------GTLLGYR 368
            .:..|...|.|:.||..|                  ::.||.::....|.:       .||....
  Fly   736 QQKGPPEKPTNLRATEVGHNYVSLSWDPGFDGGLSKTKFFVSYRRVAMPREEQLIPDCATLANSN 800

Human   369 LAYQGQDTPEVLMDIGLRQEVTLELQGDGSVSNLTVCVAAYTAAGDGPWSLPVPLEAWRPGQAQP 433
            .|:         :::..::::..::.......:....|.|.....|.|:|..: :...:..:..|
  Fly   801 SAW---------VEVDCQRDIPCKVTALEQHQSYAFKVKALNPKSDSPYSSEI-MVTTKVSRIPP 855

Human   434 VHQLVKEPSTPAFSWPWWYVLLGAVVAAACVLILALFLVHRRKKETRYGEVFEPTVERGELVVRY 498
            ..|:..||:|..         ||..|.|.|:.::|               |.|..|.....:..:
  Fly   856 PLQVTYEPNTRT---------LGIDVGATCLNLVA---------------VVESMVNADSPMAAW 896

Human   499 RVRKSYSRRTTEATLNSLGISEELKEKLRDVMVDRHKV----ALGKTLGEGEFGAVMEGQLNQDD 559
            .|      .||...|...|.....|||:.|.::...:|    |||.|:.|.|          .|:
  Fly   897 EV------VTTMDNLQLSGNGPTHKEKIIDRIIGARRVGGGRALGHTISEDE----------DDN 945

Human   560 SILKVAVK-----TMKIAICTRSELE------------DFLSEAVCMKEFDHPNVMRLIGVC 604
            .:..:|::     |:::.:|.|:..|            .:::||..:..   |.::.:|..|
  Fly   946 GLNSLALEDENSPTVRVKLCLRTNPEHCGDYTDAEIGRPYIAEANALAT---PTLIAIIVSC 1004

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AXLNP_068713.2 interaction with Gas6 26..92 26/88 (30%)
Ig 53..119 CDD:319273 20/81 (25%)
Ig2_Axl_Tyro3_like 141..222 CDD:143226 24/109 (22%)
FN3 225..328 CDD:238020 25/120 (21%)
fn3 335..418 CDD:306538 15/107 (14%)
PTKc_Axl 535..811 CDD:270660 18/91 (20%)
edNP_001260013.1 Ig 50..147 CDD:299845
I-set 146..249 CDD:254352
Ig 168..249 CDD:299845
IGc2 268..323 CDD:197706
Ig_3 341..406 CDD:290638 2/5 (40%)
Ig_2 437..514 CDD:290606 23/90 (26%)
I-set 526..633 CDD:254352 25/111 (23%)
Ig 546..632 CDD:143165 20/90 (22%)
IG_like 654..736 CDD:214653 21/103 (20%)
Ig 656..734 CDD:143165 21/99 (21%)
FN3 741..848 CDD:238020 16/116 (14%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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