Protein Alignment AXL and kin-5

DIOPT Version :9

• Sequence 1: NP_068713.2
• Gene: AXL / 558
• HGNCID: 905
• Length: 894
• Species: Homo sapiens
• Sequence 2: NP_501793.1
• Gene: kin-5 / 188489
• WormBaseID: WBGene00002193
• Length: 533
• Species: Caenorhabditis elegans
• Alignment Length: 465
• Identity: 121/465 - (26%)
• Similarity: 212/465 - (45%)
• Gaps: 94/465 - (20%)

Human   437 LVKEPSTPAFSWPWWYVLLGAVVAAACVLILALFLVHRRKKETRYGE-------VFEPTVERGEL 494
            |.||        ||::.||........:.....|||  |..:.:.||       |:...:|.
 Worm    11 LAKE--------PWYHGLLPREDMKQLLTQRGDFLV--RFTDPKVGEPRKFVLSVYVGVIED--- 62

Human   495 VVRYRVRKSYSRRTTEATLNSLGISEELKEKLRDVMVDRHK------------------------ 535
             :|:.|.:.::        |...:.::....:.|::...|:
 Worm    63 -IRHYVIREHN--------NKFAVDKKWFSSIADLLNYYHRSKEPVAGGPETVIIRPIGREPWEK 118

Human   536 ----VALGKTLGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSELEDFLSEAVCMKEFDHPN 596
                |.|.|.||||.||.|..|::...:::.|.|:|..|:...|:.::::.:.||..|::|.|||
 Worm   119 QHSDVTLIKKLGEGAFGEVQLGEIRIGNTVKKAAIKLAKLESLTKEQIKEIMHEARLMRKFKHPN 183

Human   597 VMRLIGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRLGDQPVYLPTQMLVKFMADIASGME 661
            |:...||. .|.|    |. :||:....:|.|.|: |...:|..|:.....|:::    ...|:|
 Worm   184 VVTFYGVA-AGQE----PL-MVIMELADNGALDSY-LKKNIGSLPISKKHTMVLQ----AGLGLE 237

Human   662 YLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYYRQGRIAKMPVKWIAIESLADRVY 726
            ||.:.:.||||:|:|||:.. |..|.::|||||::.|:   ||.....|:|::|:|.|......|
 Worm   238 YLHSLQIIHRDIASRNCLYG-NGQVKISDFGLSREGYS---YRMNPHKKVPIRWLAPEVPRTGFY 298

Human   727 TSKSDVWSFGVTMWEIATRGQTPYPGVENSEIYDYLRQGNRLKQPADCLDGLYALMS-RCWELNP 790
            |.|:||:::||..||:...|..||||::.:|:...::.|.|:...|:....:...:: |......
 Worm   299 TPKTDVFAYGVMCWEVYHDGIEPYPGMKVAEVLPRVQNGYRMPFEANVPPAIVRFITYRICAGAE 363

Human   791 QDRPSFTE-LREDLENTLKALPPA-------QEPDEILYVNMDEGGGYPEP-------PGAAGGA 840
            ::|.:.:| :||.|  ||:....|       :.||.|...|:::    |:.       |..:...
 Worm   364 EERVTMSEAVRELL--TLEGFDQAPGSNSYFELPDHIPMENIEQ----PKKIQVSNILPYMSKPV 422

Human   841 DPPTQPDPKD 850
            .||.:|:.::
 Worm   423 APPFEPERQE 432

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AXL	NP_068713.2	interaction with Gas6	26..92
		Ig	53..119	CDD:319273
		Ig2_Axl_Tyro3_like	141..222	CDD:143226
		FN3	225..328	CDD:238020
		fn3	335..418	CDD:306538
		PTKc_Axl	535..811	CDD:270660	91/305 (30%)
kin-5	NP_501793.1	SH2_Fps_family	11..99	CDD:198224	20/109 (18%)
		TyrKc	123..376	CDD:197581	87/267 (33%)
		PTKc	127..376	CDD:270623	85/263 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910