Protein Alignment PRKCB and aPKC

DIOPT Version :10

• Sequence 1: NP_002729.2
• Gene: PRKCB / 5579
• HGNCID: 9395
• Length: 673
• Species: Homo sapiens
• Sequence 2: NP_001260984.1
• Gene: aPKC / 47594
• FlyBaseID: FBgn0261854
• Length: 958
• Species: Drosophila melanogaster
• Alignment Length: 671
• Identity: 234/671 - (34%)
• Similarity: 308/671 - (45%)
• Gaps: 200/671 - (29%)

Human     4 PAAGPPPSEGEESTVRFARKGALRQKNVHEVKNHKFTARFFKQPTFCSHCTDFIWGFGKQGFQCQ 68
            |.|.....:||:.::  .|:||.|.:.::.|..|.|.|:.|.:..||::|.|.|||.|:|||:|.
  Fly   467 PQAPGLSCDGEDRSI--YRRGARRWRKLYRVNGHIFQAKRFNRRAFCAYCQDRIWGLGRQGFKCI 529

Human    69 VCCFVVHKRCHEFVTFSCPGADKGPASDDPRSKHKFKIHTYSSPTFCDHCGSLLYGLIHQGMKCD 133
            .|..:|||:||:.|...|        :|.|....|.:....|.|
  Fly   530 QCKLLVHKKCHKLVQKHC--------TDQPEPLVKERAEESSDP--------------------- 565

Human   134 TCMMNVHKRCVMNVPSLCGTDHTERRGRIYIQAHIDRDVLIVLVRDAKNLVPMDPNGLSDPYVKL 198
                         :|                                   ||:.|.    ||
  Fly   566 -------------IP-----------------------------------VPLPPL----PY--- 575

Human   199 KLIPDPKSESKQKTKTIKCSLNPEWNETFRFQLKESDKDRRLSVEIWDWDLTSRNDFMGSLSFGI 263
                                                                             
  Fly   576 ----------------------------------------------------------------- 575

Human   264 SELQKASVDGWFKLLSQEEGEYFNVPVPPEGSEANEELRQKFERAKISQGTKVPEEKTTNTVSKF 328
                 .::.|..:.....:..:...|.|||.                      |.|.
  Fly   576 -----EAMSGGAEACETHDHAHIVAPPPPED----------------------PLEP-------- 605

Human   329 DNNGNRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDDVECTMVEKRV 393
               |.:.:..|.||..:.|:|:||:.||::.|.:.|..:||:|::||.:|..|:|::....||.|
  Fly   606 ---GTQRQYSLNDFELIRVIGRGSYAKVLMVELRRTRRIYAMKVIKKALVTDDEDIDWVQTEKHV 667

Human   394 LALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQ 458
            .......|||..|||||||..||:||:|:|.|||||||:|:..|..|.||.||||||::.|.||.
  Fly   668 FETASNHPFLVGLHSCFQTPSRLFFVIEFVRGGDLMYHMQRQRRLPEEHARFYAAEISLALNFLH 732

Human   459 SKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVD 523
            .|||||||||||||:||.|||||:.|:|||||.|..|.||.||||||:||||||:..:.||.|||
  Fly   733 EKGIIYRDLKLDNVLLDHEGHIKLTDYGMCKEGIRPGDTTSTFCGTPNYIAPEILRGEDYGFSVD 797

Human   524 WWAFGVLLYEMLAGQAPF------EGED---EDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKH 579
            |||.||||||||||::||      |..|   ||.|||.|:|..:..|:|:|..|.::.||.:.|:
  Fly   798 WWALGVLLYEMLAGRSPFDLAGASENPDQNTEDYLFQVILEKTIRIPRSLSVRAASVLKGFLNKN 862

Human   580 PGKRLGCGPEGE-RDIKEHAFFRYIDWEKLERKEIQPPYKPKA-CGRNAENFDRFFTRHPPVLTP 642
            |..||||..|.. .||..|.||:.:|||.||||::.||:||:. ..|:..||...||.....|||
  Fly   863 PADRLGCHRESAFMDIVSHPFFKNMDWELLERKQVTPPFKPRLDSDRDLANFPPEFTGEAVQLTP 927

Human   643 PDQEVIRNIDQSEFEGFSFVN 663
            .|..||.||||||||||.:||
  Fly   928 DDDHVIDNIDQSEFEGFEYVN 948

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PRKCB	NP_002729.2	C1_cPKC_rpt1	35..92	CDD:410383	24/56 (43%)
		C1_cPKC_rpt2	102..155	CDD:410386	4/52 (8%)
		C2_PKC_alpha_gamma	159..289	CDD:175992	6/129 (5%)
		STKc_cPKC_beta	341..663	CDD:270767	179/332 (54%)
aPKC	NP_001260984.1	C1_aPKC	496..550	CDD:410344	24/61 (39%)
		STKc_aPKC	620..947	CDD:270740	177/326 (54%)