Protein Alignment PRKCB and for

DIOPT Version :10

• Sequence 1: NP_002729.2
• Gene: PRKCB / 5579
• HGNCID: 9395
• Length: 673
• Species: Homo sapiens
• Sequence 2: NP_477487.1
• Gene: for / 44817
• FlyBaseID: FBgn0000721
• Length: 1088
• Species: Drosophila melanogaster
• Alignment Length: 429
• Identity: 124/429 - (28%)
• Similarity: 210/429 - (48%)
• Gaps: 48/429 - (11%)

Human   228 RFQLKESDKDRRLSVEIWDWDLTSRNDFMGSLSFGISELQKA-----SVDGWFKLLSQEEGEYFN 287
            |..:|:.|......:.     :..:.||.|..:....:|:.|     |.||...|:.  :.|.||
  Fly   684 RVTIKQQDTQEEKFIR-----MLGKGDFFGEKALQGDDLRTANIICESADGVSCLVI--DRETFN 741

Human   288 VPVPPEGSEAN-EELRQKFERAKISQGTKVPEEKTTNTVSKFDNNGNRDRMKLTDFNFLMVLGKG 351
            ..:      :| :|::.:::.....:..|:.||             .|| :.|||...:..||.|
  Fly   742 QLI------SNLDEIKHRYDDEGAMERRKINEE-------------FRD-INLTDLRVIATLGVG 786

Human   352 SFGKVMLSERKG-TDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDR 415
            .||:|.|.:..| :...:|:|.:||..:::....:..|.||.::. .....|:.:|...|:....
  Fly   787 GFGRVELVQTNGDSSRSFALKQMKKSQIVETRQQQHIMSEKEIMG-EANCQFIVKLFKTFKDKKY 850

Human   416 LYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHI 480
            ||.:||...||:|...::..|.|.:....||.|.:.....:|.|:.|||||||.:|::|:..|::
  Fly   851 LYMLMESCLGGELWTILRDKGNFDDSTTRFYTACVVEAFDYLHSRNIIYRDLKPENLLLNERGYV 915

Human   481 KIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGED 545
            |:.|||..|: :..|..|.||||||:|:|||:|..:.:..|.|:|:.|||::|:|.|..||.|.|
  Fly   916 KLVDFGFAKK-LQTGRKTWTFCGTPEYVAPEVILNRGHDISADYWSLGVLMFELLTGTPPFTGSD 979

Human   546 EDELFQSIME--HNVAYPKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKL 608
            ....:..|::  ..:.:|:::::.|..:.|.|...:|.:|||....|..:|::|.:|....|..|
  Fly   980 PMRTYNIILKGIDAIEFPRNITRNASNLIKKLCRDNPAERLGYQRGGISEIQKHKWFDGFYWWGL 1044

Human   609 ERKEIQPPYKPKACG-RNAENFDRFFTRHPPVLTPPDQE 646
            :...::||.||.... .:..|||.:         |||.|
  Fly  1045 QNCTLEPPIKPAVKSVVDTTNFDDY---------PPDPE 1074

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PRKCB	NP_002729.2	C1_cPKC_rpt1	35..92	CDD:410383
		C1_cPKC_rpt2	102..155	CDD:410386
		C2_PKC_alpha_gamma	159..289	CDD:175992	15/65 (23%)
		STKc_cPKC_beta	341..663	CDD:270767	100/310 (32%)
for	NP_477487.1	DD_cGKI-alpha	385..432	CDD:213374
		CAP_ED	520..629	CDD:237999
		CAP_ED	638..754	CDD:237999	17/82 (21%)
		STKc_cGK	783..1043	CDD:270724	87/261 (33%)