Protein Alignment PRKCB and Pkc98E

DIOPT Version :10

• Sequence 1: NP_002729.2
• Gene: PRKCB / 5579
• HGNCID: 9395
• Length: 673
• Species: Homo sapiens
• Sequence 2: NP_524545.2
• Gene: Pkc98E / 43428
• FlyBaseID: FBgn0003093
• Length: 739
• Species: Drosophila melanogaster
• Alignment Length: 680
• Identity: 314/680 - (46%)
• Similarity: 404/680 - (59%)
• Gaps: 134/680 - (19%)

Human    22 RKGALRQKNVHEVKNHKFTARFFKQPTFCSHCTDFIWGFGKQGFQCQVCCFVVHKRCHEFVTFSC 86
            |:||:|:: ||:|..|||.|.|.:||||||||.:||||.||||:|||||..||||:||..|...|
  Fly   163 RRGAMRRR-VHQVNGHKFMATFLRQPTFCSHCREFIWGIGKQGYQCQVCTLVVHKKCHLSVVSKC 226

Human    87 PG-ADKGPASDD--PRSK-------HKFKIHTYSSPTFCDHCGSLLYGLIHQGMKCDTCMMNVHK 141
            || .|:.||..:  |..:       |:|.:|:|...||||||||||||||.||::|:||.|||||
  Fly   227 PGMRDEQPAKVEMVPAGQRFNVNLPHRFVVHSYKRFTFCDHCGSLLYGLIKQGLQCETCGMNVHK 291

Human   142 RCVMNVPSLCGTDHTERRGRIYIQAHIDRDVLIVLVRDAKNLVPMDPNGLSDPYVKLKLIPDPKS 206
            ||..||.:.||. :|::...|                            ||    .|.:.||.:.
  Fly   292 RCQKNVANTCGI-NTKQMAEI----------------------------LS----SLGISPDKQQ 323

Human   207 ESKQKTKTIKCSLNPEWNETFRFQLKESDKDRRLSVEIWDWDLTSRNDFMGSLSFGISELQKASV 271
            ..:.|      .||.:..|                           :::..||
  Fly   324 PRRSK------YLNQQGGE---------------------------DNYGASL------------ 343

Human   272 DGWFKLLSQEEGEYFNVPVPPEGSEANEELRQKFERAKISQGTKVPEEKTTNTVSKFDNNG---- 332
                                  |::.:....|.|....:|..:..  ..||...|.::::.
  Fly   344 ----------------------GADGDGAPGQSFRSCALSVDSLA--TSTTTMTSGYNSSSCMSL 384

Human   333 --------------NRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDDD 383
                          ...:..|.||||:.||||||||||||:|:|||||:||:|:||||.:|||||
  Fly   385 AVTGSGGVGATGETRPGKCSLLDFNFIKVLGKGSFGKVMLAEKKGTDEIYAIKVLKKDAIIQDDD 449

Human   384 VECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAA 448
            |:|||.|||:|||....||||.|||||||.|||:||||||||||||:.||:..||:...|.||||
  Fly   450 VDCTMTEKRILALAANHPFLTALHSCFQTPDRLFFVMEYVNGGDLMFQIQKARRFEASRAAFYAA 514

Human   449 EIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEII 513
            |:.:.|.||.:.|:|||||||||::||.|||.|:||||||||.|.:|:.|.|||||||||||||:
  Fly   515 EVTLALQFLHTHGVIYRDLKLDNILLDQEGHCKLADFGMCKEGIMNGMLTTTFCGTPDYIAPEIL 579

Human   514 AYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTK 578
            ..|.||.||||||.|||:|||:|||.|||.::|||||.|||..:|.||..:|:|||:|.||.:||
  Fly   580 KEQEYGASVDWWALGVLMYEMMAGQPPFEADNEDELFDSIMHDDVLYPVWLSREAVSILKGFLTK 644

Human   579 HPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKACG-RNAENFDRFFTRHPPVLTP 642
            :|.:||||..: |.:|::|.||..:||::||::.|:||::||... |:|.|||..||:..|||||
  Fly   645 NPEQRLGCTGD-ENEIRKHPFFAKLDWKELEKRNIKPPFRPKMKNPRDANNFDAEFTKEDPVLTP 708

Human   643 PDQEVIRNIDQSEFEGFSFVNSEFLKPEVK 672
            ...||:|.|:|.||.||||||.:| .||.|
  Fly   709 IGNEVVRCINQDEFAGFSFVNPKF-GPERK 737

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PRKCB	NP_002729.2	C1_cPKC_rpt1	35..92	CDD:410383	37/57 (65%)
		C1_cPKC_rpt2	102..155	CDD:410386	34/52 (65%)
		C2_PKC_alpha_gamma	159..289	CDD:175992	12/129 (9%)
		STKc_cPKC_beta	341..663	CDD:270767	206/322 (64%)
Pkc98E	NP_524545.2	C2_PKC_epsilon	1..134	CDD:175981
		C1_nPKC_epsilon-like_rpt1	171..230	CDD:410385	39/58 (67%)
		C1_nPKC_epsilon-like_rpt2	250..304	CDD:410388	34/54 (63%)
		STKc_nPKC_epsilon	412..729	CDD:270743	202/317 (64%)