Protein Alignment PRKCB and JIL-1

DIOPT Version :10

• Sequence 1: NP_002729.2
• Gene: PRKCB / 5579
• HGNCID: 9395
• Length: 673
• Species: Homo sapiens
• Sequence 2: NP_648432.1
• Gene: JIL-1 / 39241
• FlyBaseID: FBgn0020412
• Length: 1207
• Species: Drosophila melanogaster
• Alignment Length: 469
• Identity: 150/469 - (31%)
• Similarity: 220/469 - (46%)
• Gaps: 81/469 - (17%)

Human   263 ISELQKASVDGWFKLLSQEEGEYFNVPV---PPEGSEANEELRQKFERAK--------------- 309
            ||:.:  |.||     ...|.||::..:   .|.|.|.:|. .....:||
  Fly   146 ISDAE--SEDG-----RDPEREYYDQDMEEDEPNGIEIDES-SSSLSKAKSNNAAAAAAAAAAAA 202

Human   310 ISQGTKVPEEKT--------TNTVSKFDNNGNR------------------DRMKLTDFNFLMVL 348
            .:..:|.....|        .:|....||..::                  :.:.|.||..:.||
  Fly   203 AAAASKASSSTTPSYAMPTSNSTPLDLDNEAHQRDLEAVTDLKYYVKLYSDEAVSLNDFKIIRVL 267

Human   349 GKGSFGKVMLSE---RKGTDELYAVKILKKDVVIQD-DDVECTMVEKRVLALPGKPPFLTQLHSC 409
            |.|::|:|.|..   |....:|||:|:|.|..|:|. ...|.|..|:.||....:.|||..||..
  Fly   268 GTGAYGRVFLVRKLTRHDAGKLYAMKVLNKITVVQKRKTAEHTKTERVVLEAIQRNPFLVSLHYA 332

Human   410 FQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVML 474
            ||:..:||.|:::.|||:|..|:.....|:|.....|.||:.:.|..|...||||||:||:|::|
  Fly   333 FQSSSKLYLVLDFANGGELFTHLYHSENFEESRVRVYIAEVVLALEQLHQLGIIYRDIKLENILL 397

Human   475 DSEGHIKIADFGMCK----ENIWDGVTTKTFCGTPDYIAPEIIAYQPYG--KSVDWWAFGVLLYE 533
            |.||||.::|||:.|    ||.:   ...:||||.:|:|||||...|.|  .:||||:.|||.:|
  Fly   398 DGEGHIVLSDFGLSKILTAENEY---RAHSFCGTLEYMAPEIIRTGPPGHDSAVDWWSVGVLTFE 459

Human   534 MLAGQAPFEGED----EDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDI 594
            :|.|.:||...|    :.|:.:.|.:.....|.|.|..|......::.|:|.:|||.......:|
  Fly   460 LLTGASPFATSDGQVQQSEISRRIQKEQPMIPSSFSANARDFVLKMLEKNPKRRLGGNHRDASEI 524

Human   595 KEHAFFRYIDWEKLERKEIQPPYKPKACGR-NAENFDRFFT----RHPPVLTPPDQEVIRNIDQS 654
            |||.||..|:|::|..|..:.||||..... :.:||...||    ..|....||.:  ||
  Fly   525 KEHPFFNGINWQELRTKRRKAPYKPTLTAEDDVQNFSNEFTDQVPEDPECDAPPSR--IR----- 582

Human   655 EFEGFSFVNSEFLK 668
            .|.|:::|..|.|:
  Fly   583 LFRGYTYVAPEHLE 596

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PRKCB	NP_002729.2	C1_cPKC_rpt1	35..92	CDD:410383
		C1_cPKC_rpt2	102..155	CDD:410386
		C2_PKC_alpha_gamma	159..289	CDD:175992	8/25 (32%)
		STKc_cPKC_beta	341..663	CDD:270767	127/340 (37%)
JIL-1	NP_648432.1	STKc_MSK_N	266..533	CDD:270735	106/269 (39%)
		S_TK_X	532..591	CDD:214529	19/65 (29%)
		S_TKc	632..886	CDD:214567