Protein Alignment PRKCB and S6k

DIOPT Version :10

• Sequence 1: NP_002729.2
• Gene: PRKCB / 5579
• HGNCID: 9395
• Length: 673
• Species: Homo sapiens
• Sequence 2: NP_523941.2
• Gene: S6k / 38654
• FlyBaseID: FBgn0283472
• Length: 490
• Species: Drosophila melanogaster
• Alignment Length: 352
• Identity: 132/352 - (37%)
• Similarity: 212/352 - (60%)
• Gaps: 9/352 - (2%)

Human   324 TVSKFDNNGNRDRMKL--TDFNFLMVLGKGSFGKV-MLSERKGTD--ELYAVKILKK-DVVIQDD 382
            |:...:.|.|..::||  .||....|||||.:||| .:.:..|.|  :.:|:|:||| .:|....
  Fly    57 TIQLCEENVNPGKIKLGPKDFELKKVLGKGGYGKVFQVRKTAGRDANKYFAMKVLKKASIVTNQK 121

Human   383 DVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYA 447
            |...|..|:.:|... |.||:.:|...|||..:||.::||::||:|..|:::.|.|.|....||.
  Fly   122 DTAHTRAERNILEAV-KHPFIVELVYAFQTDGKLYLILEYLSGGELFMHLEREGIFLEDTTCFYL 185

Human   448 AEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEI 512
            :||.:.|..|...||||||||.:|::||::||:|:.|||:|||:|.:|:.|.|||||.:|:||||
  Fly   186 SEIILALGHLHKLGIIYRDLKPENILLDAQGHVKLTDFGLCKEHIQEGIVTHTFCGTIEYMAPEI 250

Human   513 IAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMT 577
            :....:||:||||:.|.|:::||.|..||..|:..:..::|::..:..|..::.||..:.:.||.
  Fly   251 LTRSGHGKAVDWWSLGALMFDMLTGVPPFTAENRKKTIETILKAKLNLPAYLTPEARDLVRRLMK 315

Human   578 KHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKACGR-NAENFDRFFTRHPPVLT 641
            :...:|||.|||....::.|.||::::|:.:..:.::||.||..... :...||..|||..||.:
  Fly   316 RQEPQRLGSGPEDAAAVQIHPFFKHVNWDDVLARRLEPPIKPLLRSEDDVSQFDTRFTRQIPVDS 380

Human   642 PPDQEVIRNIDQSEFEGFSFVNSEFLK 668
            |.|..:..:.:.. |:||::|....|:
  Fly   381 PDDTTLSESANLI-FQGFTYVAPSILE 406

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PRKCB	NP_002729.2	C1_cPKC_rpt1	35..92	CDD:410383
		C1_cPKC_rpt2	102..155	CDD:410386
		C2_PKC_alpha_gamma	159..289	CDD:175992
		STKc_cPKC_beta	341..663	CDD:270767	125/326 (38%)
S6k	NP_523941.2	STKc_p70S6K	81..402	CDD:270736	124/322 (39%)