Protein Alignment PRKCB and inaC

DIOPT Version :10

• Sequence 1: NP_002729.2
• Gene: PRKCB / 5579
• HGNCID: 9395
• Length: 673
• Species: Homo sapiens
• Sequence 2: NP_476863.1
• Gene: inaC / 36897
• FlyBaseID: FBgn0004784
• Length: 700
• Species: Drosophila melanogaster
• Alignment Length: 682
• Identity: 349/682 - (51%)
• Similarity: 467/682 - (68%)
• Gaps: 30/682 - (4%)

Human     4 PAAGPPPS-------EGEESTVRF----ARKGALRQKNVHEVKNHKFTARFFKQPTFCSHCTDFI 57
            ||||....       .||.:.|.:    .||||:::|.:..|..|:|..||||.||:|.||.|||
  Fly    28 PAAGAGKGPGNLLEITGEANIVNYMKNRLRKGAMKRKGLEMVNGHRFGVRFFKNPTYCGHCKDFI 92

Human    58 WGFGKQGFQCQVCCFVVHKRCHEFVTFSCPGADKGPASDDPRSKHKFKIHTYSSPTFCDHCGSLL 122
            ||||||||||:.|.|.:|::|.:||.|.|||.|....:|..:.||.:...||::|||||.||.||
  Fly    93 WGFGKQGFQCEECRFNIHQKCCKFVVFKCPGKDTDFDADCAKVKHGWISTTYTTPTFCDECGLLL 157

Human   123 YGLIHQGMKCDTCMMNVHKRCVMNVPSLCGTDHTERRGRIYIQAHIDRDVLIVLVRDAKNLVPMD 187
            :|:.|||:||:.|.:|||..|...||.:||.|.:|.||::.:...:..:.|.|.:::|.||:|||
  Fly   158 HGVAHQGVKCENCNLNVHHACQETVPPMCGADISEVRGKLLLYVELKGNNLKVDIKEAANLIPMD 222

Human   188 PNGLSDPYVKLKLIPDPKSESKQKTKTIKCSLNPEWNETFRFQLKESDKDRRLSVEIWDWDLTSR 252
            .||.||||:.:::.||....:|:|||||:.:|||.:||||.|:|:..|:|:||.:|:||||.|||
  Fly   223 TNGFSDPYIAVQMHPDRSGRTKKKTKTIQKNLNPVFNETFTFELQPQDRDKRLLIEVWDWDRTSR 287

Human   253 NDFMGSLSFGISELQKASVDGWFKLLSQEEGEYFNVPVPPEGSEANEELRQKFERAKISQGTKVP 317
            ||||||.||.:.||||..||||:|.|||.|||::|:|..   ...|:..|.:.|         |.
  Fly   288 NDFMGSFSFSLEELQKEPVDGWYKFLSQVEGEHYNIPCV---DAFNDIARLRDE---------VR 340

Human   318 EEKTTNTVSKFDNN------GNRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKD 376
            .::..|...:.||.      ..||.::..||||:.|:||||||||:|:||:|||||||||:|:||
  Fly   341 HDRRPNEKRRMDNKDMPHNMSKRDMIRAADFNFVKVIGKGSFGKVLLAERRGTDELYAVKVLRKD 405

Human   377 VVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEP 441
            |:||.||:|..|.||::|||.|:||||..:||||||||||:|||||..|||||||:||.|||||.
  Fly   406 VIIQTDDMELPMNEKKILALSGRPPFLVSMHSCFQTMDRLFFVMEYCKGGDLMYHMQQYGRFKES 470

Human   442 HAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPD 506
            .|:|||.|:||.||||..:.||||||||||::||.|||:|:.|||:.||.:.:..||:||||||:
  Fly   471 VAIFYAVEVAIALFFLHERDIIYRDLKLDNILLDGEGHVKLVDFGLSKEGVTERQTTRTFCGTPN 535

Human   507 YIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAI 571
            |:||||::|.||..:.|||:|||||:|.:||||||||:||..:|::|.:....:||..|.||:.|
  Fly   536 YMAPEIVSYDPYSIAADWWSFGVLLFEFMAGQAPFEGDDETTVFRNIKDKKAVFPKHFSVEAMDI 600

Human   572 CKGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYKPKACGR-NAENFDRFFTR 635
            ....:||.|..|||.|....::|..|.|||.:||:|.|..|::||.||....| :..|||..||:
  Fly   601 ITSFLTKKPNNRLGAGRYARQEITTHPFFRNVDWDKAEACEMEPPIKPMIKHRKDISNFDDAFTK 665

Human   636 HPPVLTPPDQEVIRNIDQSEFEGFSFVNSEFL 667
            ....|||.|:..:.|:||::|.||||:|.||:
  Fly   666 EKTDLTPTDKLFMMNLDQNDFIGFSFMNPEFI 697

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PRKCB	NP_002729.2	C1_cPKC_rpt1	35..92	CDD:410383	35/56 (63%)
		C1_cPKC_rpt2	102..155	CDD:410386	27/52 (52%)
		C2_PKC_alpha_gamma	159..289	CDD:175992	69/129 (53%)
		STKc_cPKC_beta	341..663	CDD:270767	188/322 (58%)
inaC	NP_476863.1	C1_cPKC_nPKC_rpt1	71..123	CDD:410342	32/51 (63%)
		C1	137..190	CDD:412127	27/52 (52%)
		C2_PKC_alpha_gamma	194..324	CDD:175992	69/129 (53%)
		STKc_PKC	375..692	CDD:270722	183/316 (58%)