Protein Alignment PRKCB and CG4839

DIOPT Version :10

• Sequence 1: NP_002729.2
• Gene: PRKCB / 5579
• HGNCID: 9395
• Length: 673
• Species: Homo sapiens
• Sequence 2: NP_609349.1
• Gene: CG4839 / 34348
• FlyBaseID: FBgn0032187
• Length: 1003
• Species: Drosophila melanogaster
• Alignment Length: 628
• Identity: 158/628 - (25%)
• Similarity: 275/628 - (43%)
• Gaps: 127/628 - (20%)

Human    88 GADKGPASDDPRSKHKFKIH---TYSSPTF-------------CDHCGSLLYGLIHQGMKCDTCM 136
            ||::...|.|..:....::.   .|..|.|             .:...:|:...|.:....:..|
  Fly   372 GAEESHKSSDSSTPKTHRVEGGLIYVRPNFPIQSDIEIESIAKDEGTRNLIRTAIERNDFLNNLM 436

Human   137 MNVHKRCVMNV--------PSLCGTDHTERRGRIYIQAHIDRDVLIVLVRDAKNLVPMDPNGLSD 193
            ....|..|:|.        .||...:| |....||:.|....||    :|..:.:....|   :.
  Fly   437 DKERKEMVINAMAPASYRKHSLIIREH-EEGSEIYVSAEGQYDV----IRGGQLVASFGP---AT 493

Human   194 PYVKLKLIPDPKSESKQKTKT---------------IKCSLNPEWNETFRFQ-----LKESDKDR 238
            .:.:|.::.:...::..:..|               ::.|.:.|..|..:|.     |:|.|:..
  Fly   494 VFGELAILYNAPRQASIEAATDARVWKIARETFRAIMQISGSREREENLQFLRSAPFLQEFDQSL 558

Human   239 RLSVEIWDWDLTSR----------------NDF----MGSLSF-GISELQKASVDGWFKLLSQEE 282
            .|.|.    ||..|                |:|    .|:::. .:.|.|:..:     :.:::.
  Fly   559 LLKVV----DLLQRKFYETDSCIVREGELGNEFYIIRCGTVTIKKLDEQQQEQI-----VANRKR 614

Human   283 GEYFNVPVPPEGSEA--NEELRQKFERAKISQGTKV---------------------PEEKTTNT 324
            |:||       |.:|  |.::||....|. :.||:|                     |..:..:|
  Fly   615 GDYF-------GEQALLNADVRQASVYAD-APGTEVLMLDREAFISYLGTIKQLREKPSSQRNDT 671

Human   325 VSK-------FDNNGNRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDELYAVKILKKDVVIQDD 382
            ..:       |||  ...::.:::...:..||.|:||:|.|...  ..:..|:||:||..|::.|
  Fly   672 SGRSSTKSLEFDN--EYSQVAISELKKIATLGCGAFGRVDLVAY--NQQALALKIIKKIEVVKQD 732

Human   383 DVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYA 447
            .:|....||.|:....:.||:.||:..::....:||:||...|||:...:.:...|.|..|.|.|
  Fly   733 QIEHVYNEKNVMIKCRQSPFIVQLYRTYRNDKYVYFLMEACMGGDVWTVMSKRQYFDEKTAKFIA 797

Human   448 AEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEI 512
            ..:.....:|.|...||||||.:|:||.::|:.|:.|||..| .:.....|.||.|||:|:||||
  Fly   798 GCVVEAFDYLHSHHFIYRDLKPENLMLGTDGYCKLVDFGFAK-FVRQNEKTNTFAGTPEYVAPEI 861

Human   513 IAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIME--HNVAYPKSMSKEAVAICKGL 575
            |..:.:.::||:||.|:|:||:|.|:.||.|.::.:::|.|:.  ..:..|..:.|.|..:.:.|
  Fly   862 ILDRGHDRAVDYWALGILVYELLVGKTPFRGVNQIKIYQQILSGIDVIHMPSRIPKSAQHLVRHL 926

Human   576 MTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPYK 618
            ..:.|.:|||...:|..|||.|::|..:||::|:.|::..|.|
  Fly   927 CKQLPAERLGYQRKGIADIKRHSWFESLDWQRLKLKQLPSPIK 969

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PRKCB	NP_002729.2	C1_cPKC_rpt1	35..92	CDD:410383	2/3 (67%)
		C1_cPKC_rpt2	102..155	CDD:410386	11/76 (14%)
		C2_PKC_alpha_gamma	159..289	CDD:175992	29/170 (17%)
		STKc_cPKC_beta	341..663	CDD:270767	98/280 (35%)
CG4839	NP_609349.1	CAP_ED	431..539	CDD:237999	19/115 (17%)
		CAP_ED	550..663	CDD:237999	25/129 (19%)
		STKc_cGK	700..957	CDD:270724	93/259 (36%)