Protein Alignment PRKCB and Pkg21D

DIOPT Version :10

• Sequence 1: NP_002729.2
• Gene: PRKCB / 5579
• HGNCID: 9395
• Length: 673
• Species: Homo sapiens
• Sequence 2: NP_477213.1
• Gene: Pkg21D / 33253
• FlyBaseID: FBgn0000442
• Length: 768
• Species: Drosophila melanogaster
• Alignment Length: 781
• Identity: 182/781 - (23%)
• Similarity: 314/781 - (40%)
• Gaps: 202/781 - (25%)

Human    14 EESTVRFAR-----KGALRQ--KNVHEVKNHKFTARFFKQPTFCSHCTDFIWGFGKQGFQCQ--- 68
            |...|:..|     |..|:|  .|::..:|.|...:.:..|..|          |:|..:.|
  Fly    33 ESELVKLHREIHKLKSVLQQTTNNLNVTRNEKAKKKLYSLPEQC----------GEQESRNQNPH 87

Human    69 VC--CFVVHKRCHEFVTFS------CPGADKGPASDDPRSKHKFKIHTYSSPTFCDHCGSLLYGL 125
            :|  |.:|.....||...:      .|.|....||...|:... ::...:.|.          .:
  Fly    88 LCSSCGMVLPTSPEFALEALSLGPLSPLASTSSASPSGRTSAD-EVRPKAMPA----------AI 141

Human   126 IHQGMKCDTCMMNVHKRCVMNVP----------------------------------------SL 150
            ..||:..::|:.::.:...:.:|                                        |:
  Fly   142 KKQGVSAESCVQSMQQSYSIPIPKYEKDFSDKQQIKDAIMDNDFLKNIDASQVRELVDSMYSKSI 206

Human   151 CGTDHTERRGRIYIQAHIDRDVLIVLVRDAKNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTI 215
            ...:...|.|.:....::.......:::..|.|   |..|....:.:|.::     .:..:|.:|
  Fly   207 AAGEFVIREGEVGAHLYVSAAGEFAVMQQGKVL---DKMGAGKAFGELAIL-----YNCTRTASI 263

Human   216 KCSLNPEWNETFRFQLKESDK----DRRLSVEIWDWD----LTSRNDFMGS--LSFGISELQKAS 270
            :.             |.|:.:    |||:..:|....    :.:..:|:.|  |...:||...|.
  Fly   264 RV-------------LSEAARVWVLDRRVFQQIMMCTGLQRIENSVNFLRSVPLLMNLSEELLAK 315

Human   271 VDGWFKLLSQEEGEYF----------------NV-------PVPPEGSEANEELRQKF--ERAKI 310
            :....:|.....|.|.                ||       |..||.:|.....|..:  |:|.|
  Fly   316 IADVLELEFYAAGTYIIRQGTAGDSFFLISQGNVRVTQKLTPTSPEETELRTLSRGDYFGEQALI 380

Human   311 SQGTKVPEEKTTNTVS-------------------------KFDNNGNRDR-------------- 336
            ::     :::|.|.::                         |..:.|:..|
  Fly   381 NE-----DKRTANIIALSPGVECLTLDRDSFKRLIGDLCELKEKDYGDESRKLAMKQAQESCRDE 440

Human   337 -----------MKLTDFNFLMVLGKGSFGKVMLSERKGTD--ELYAVKILKKDVVIQDDDVECTM 388
                       :||||...:..||.|.||:|.|.:....|  :::|:|.|||..::.....|...
  Fly   441 PKEQLQQEFPDLKLTDLEVVSTLGIGGFGRVELVKAHHQDRVDIFALKCLKKRHIVDTKQEEHIF 505

Human   389 VEKRVLALPGKPPFLTQLHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIG 453
            .|:.:: |..:.||:.:|:..|:....:|.::|...||::...::..|.|::..|.|....:...
  Fly   506 SERHIM-LSSRSPFICRLYRTFRDEKYVYMLLEACMGGEIWTMLRDRGSFEDNAAQFIIGCVLQA 569

Human   454 LFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPY 518
            ..:|.::||||||||.:|:|||..|::||.|||..|: |.....|.||||||:|:|||||..:.:
  Fly   570 FEYLHARGIIYRDLKPENLMLDERGYVKIVDFGFAKQ-IGTSSKTWTFCGTPEYVAPEIILNKGH 633

Human   519 GKSVDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIME--HNVAYPKSMSKEAVAICKGLMTKHPG 581
            .::||:||.|:|::|:|.|..||...|..:.:..|::  ..:|:||.:|:.||.:.|.|....|.
  Fly   634 DRAVDYWALGILIHELLNGTPPFSAPDPMQTYNLILKGIDMIAFPKHISRWAVQLIKRLCRDVPS 698

Human   582 KRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPPY-KPKACGRNAENFDRFFTRHPPVLT-PPD 644
            :|||....|.:|||:|.:|...||:.|..:.:.||: :|.|...:...||||    |..|. |||
  Fly   699 ERLGYQTGGIQDIKKHKWFLGFDWDGLASQLLIPPFVRPIAHPTDVRYFDRF----PCDLNEPPD 759

Human   645 Q 645
            :
  Fly   760 E 760

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PRKCB	NP_002729.2	C1_cPKC_rpt1	35..92	CDD:410383	14/67 (21%)
		C1_cPKC_rpt2	102..155	CDD:410386	6/92 (7%)
		C2_PKC_alpha_gamma	159..289	CDD:175992	25/162 (15%)
		STKc_cPKC_beta	341..663	CDD:270767	110/311 (35%)
Pkg21D	NP_477213.1	CAP_ED	185..285	CDD:237999	16/120 (13%)
		CAP_ED	304..419	CDD:237999	20/119 (17%)
		STKc_cGK	463..724	CDD:270724	95/262 (36%)
		S_TK_X	719..>760	CDD:214529	15/44 (34%)