DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FGD6 and Fgd6

DIOPT Version :9

Sequence 1:	NP_060821.3	Gene:	FGD6 / 55785	HGNCID:	21740	Length:	1430	Species:	Homo sapiens
Sequence 2:	XP_036011484.1	Gene:	Fgd6 / 13998	MGIID:	1261419	Length:	1401	Species:	Mus musculus

Alignment Length:	1438	Identity:	1065/1438 - (74%)
Similarity:	1172/1438 - (81%)	Gaps:	45/1438 - (3%)

- Green bases have known domain annotations that are detailed below.

Human     1 MTSAAEIKKPPVAPKPKFVVANNKPAPPPIAPKPDIVISSVPQSTKKMKPAIAPKPKVLKTSPVR 65
            ||||||:||||:|||||.|..||||.||||||||||..:|||:.|||.||||||||||...|.|:
Mouse     1 MTSAAELKKPPLAPKPKLVGTNNKPPPPPIAPKPDIGSASVPRLTKKTKPAIAPKPKVPTNSVVQ 65

Human    66 EIGQSPSRKIMLNLEGHKQELAESTDNFNCKYEGNQSNDYISPMCSCSSECIHKLGHRENLCVKQ 130
            :|...||:|..||||..:.||.|||...|||...:..:|||.|.|||||.|||:...||..||:|
Mouse    66 DIKHPPSKKPTLNLEEREPELPESTGKSNCKDVRDPHSDYILPTCSCSSGCIHEPRTRETQCVEQ 130

Human   131 LVLEPLEMNENLENSKIDETLTIKTRSKCDLYGEKAKNQGGVVLKASVLEEELKDALIHQMPPFI 195
            ||||||.|.|||||||..|  :.|..|..|...||.:.|.|||||||:|||:||:.|..|..|..
Mouse   131 LVLEPLGMKENLENSKNGE--SSKRGSSWDSSSEKCRGQSGVVLKASILEEKLKEVLTQQRSPCG 193

Human   196 SAQKHRPTDSPEMNGGCNSNGQFRIEFADLSPSPSSFEKVPDHHSCHLQLPSDECEHFETCQDDS 260
            |..:||....|||||..:...|.||||||:|.|.:.|||||.||:||.|||.||.:..:||||.|
Mouse   194 SPGRHRAPKKPEMNGDHSCTRQIRIEFADVSSSLTGFEKVPAHHNCHPQLPRDESQTLKTCQDGS 258

Human   261 EKSNNCFQSSELEALENGKRSTLISSDGVSKKSEVKDLGPLEIHLVPYTPKFPTPKPRKTR-TAR 324
            .:|.....|.|.|    .||   ::|||:|:|:|||.||||||||:|||.||||||||||. .||
Mouse   259 AESRGHTDSCEPE----NKR---VASDGISQKTEVKGLGPLEIHLLPYTSKFPTPKPRKTHAAAR 316

Human   325 LLRQKCVDTPSESTEEPGNSDSSSSCLTEN-SLKINKISVLHQNVLCKQEQVDKMKLGNKSELNM 388
            |.|||.||||.|||||||||::.||||.|: .||.||:|||.||.|..|..||:::..|:..|..
Mouse   317 LRRQKHVDTPGESTEEPGNSNNGSSCLLEDYCLKNNKVSVLRQNALYNQGPVDEVRPANQRALTG 381

Human   389 ESNSDAQDLVNSQKAMCNETTSFEKMAPSFDKDSNLSSDSTTVDGSSMSLAVDEGTGFIRC-TVS 452
            :|||..||.|.||||:..:|       ||.|.||:|:|||:   ||.:|.|||:.|.:.:| |..
Mouse   382 DSNSGGQDSVGSQKAVQQQT-------PSLDTDSSLTSDSS---GSGVSPAVDKETTYTQCSTQP 436

Human   453 MSLPKQLKLTCNEHLQSGRNLGVSAPQMQKESVIKEENSLRIVPKKPQRHSLPATGVLKKAASEE 517
            :|||||:...|.:...:..|..||||.:||||     :|.||:|||||||||||.||||||||||
Mouse   437 LSLPKQVTSACTDQPPATCNPEVSAPPIQKES-----SSSRIIPKKPQRHSLPAAGVLKKAASEE 496

Human   518 LLEKSSYPSSEEKSSEKSLERNHLQHLCAQNRGVSSS-FDMPKRASEKPVWKLPHPILPFSGNPE 581
            |:||||  |.:|.:.||.|.||:|.|....|.|.|:| ||||...|||||||||||||||||:||
Mouse   497 LVEKSS--SGKETNVEKGLHRNYLHHPGPPNHGASASPFDMPNPTSEKPVWKLPHPILPFSGSPE 559

Human   582 FLKSVTVSSNSEPSTALTKPRAKSLSAMDVEKCTKPCKDSTKKNSFKKLLSMKLSICFMKSDFQK 646
            .||.||:|.|:|||.:|||||||||||:|.::|.|||||..||.|||||:::||||.|:||||||
Mouse   560 ALKRVTLSLNNEPSVSLTKPRAKSLSAVDADRCNKPCKDPPKKTSFKKLINVKLSIGFIKSDFQK 624

Human   647 FWSKSSQLGDTTTGHLSSGEQKGIESDWQGLLVGEEKRSKPIKAYSTENYSLESQKKRKKSRGQT 711
            ..|||.|.||.:.||..:.|.||:|||||||..||||||||.||:|.||.||||||  .||.||:
Mouse   625 IRSKSCQHGDVSAGHPLAREPKGLESDWQGLATGEEKRSKPTKAHSAENCSLESQK--VKSWGQS 687

Human   712 SAANGLRAESLDDQMLSRESSSQAPYKSVTSLCAPEYENIRHYEEIPEYENLPFIMAIRKTQELE 776
            ||.||.|||||||::|||.:|....:       .|||||:||||||||||||||:||.|.|.:|.
Mouse   688 SAVNGQRAESLDDRILSRHTSCTGDF-------GPEYENVRHYEEIPEYENLPFVMAGRNTPDLG 745

Human   777 WQNSSSMEDADANVYEVEEPYEAPDGQLQLGPRHQHSSSGASQEEQN--DLGLGDLPSDEEEIIN 839
            ||||||:||.||::|||||||.||||||||.||||..|||.|||.::  .|||.||||| ||:||
Mouse   746 WQNSSSVEDTDASLYEVEEPYNAPDGQLQLDPRHQPCSSGTSQEGKDALHLGLSDLPSD-EEVIN 809

Human   840 SSDEDDVSSESSKGEPDPLEDKQDEDNGMKSKVHHIAKEIMSSEKVFVDVLKLLHIDFRDAVAHA 904
            ||||||||||||||||||||||||||.||||||||||||||||||||||||||||||||.|||||
Mouse   810 SSDEDDVSSESSKGEPDPLEDKQDEDAGMKSKVHHIAKEIMSSEKVFVDVLKLLHIDFRGAVAHA 874

Human   905 SRQLGKPVIEDRILNQILYYLPQLYELNRDLLKELEERMLHWTEQQRIADIFVKKGPYLKMYSTY 969
            ||||||||||||||||||||||||||||||||||||||||.||||||||||||||||||||||||
Mouse   875 SRQLGKPVIEDRILNQILYYLPQLYELNRDLLKELEERMLTWTEQQRIADIFVKKGPYLKMYSTY 939

Human   970 IKEFDKNIALLDEQCKKNPGFAAVVREFEMSPRCANLALKHYLLKPVQRIPQYRLLLTDYLKNLI 1034
            |||||||:||||||||||||||||||||||||||||||||||||||||||||||||||||||||:
Mouse   940 IKEFDKNVALLDEQCKKNPGFAAVVREFEMSPRCANLALKHYLLKPVQRIPQYRLLLTDYLKNLL 1004

Human  1035 EDAGDYRDTQDALAVVIEVANHANDTMKQGDNFQKLMQIQYSLNGHHEIVQPGR--VFLKEGILM 1097
            ||:.|:|||||||||||||||||||||||||||||||||||||:||||||||||  ||||||.||
Mouse  1005 EDSVDHRDTQDALAVVIEVANHANDTMKQGDNFQKLMQIQYSLSGHHEIVQPGRNDVFLKEGTLM 1069

Human  1098 KLSRKVMQPRMFFLFNDALLYTTPVQSGMYKLNNMLSLAGMKVRKPTQEAYQNELKIESVERSFI 1162
            ||||||||||||||||||||||||:||||||||||||||||||||||||||||||||||||||||
Mouse  1070 KLSRKVMQPRMFFLFNDALLYTTPMQSGMYKLNNMLSLAGMKVRKPTQEAYQNELKIESVERSFI 1134

Human  1163 LSASSATERDEWLEAISRAIEEYAKKRITFCPSRSLDEADSENKEEVSPLGSKAPIWIPDTRATM 1227
            ||||||.|||:||||||.:||||||||||||||||||| |||.||||||||:|||||||||||||
Mouse  1135 LSASSAAERDDWLEAISSSIEEYAKKRITFCPSRSLDE-DSERKEEVSPLGAKAPIWIPDTRATM 1198

Human  1228 CMICTSEFTLTWRRHHCRACGKIVCQACSSNKYGLDYLKNQPARVCEHCFQELQKLDHQHSPRIG 1292
            |||||||||||||||||||||||||||||||||||||||.|.|||||||||||||||||.|||:|
Mouse  1199 CMICTSEFTLTWRRHHCRACGKIVCQACSSNKYGLDYLKGQLARVCEHCFQELQKLDHQLSPRVG 1263

Human  1293 SPGNHKSPSSALSSVLHSIPSGRKQKKIPAALKEVSANTEDSSMSGYLYRSKGNKKPWKHFWFVI 1357
            ||||||||||||||||||||||||||||||||||||||||||:||||||||||:||||||.||||
Mouse  1264 SPGNHKSPSSALSSVLHSIPSGRKQKKIPAALKEVSANTEDSTMSGYLYRSKGSKKPWKHLWFVI 1328

Human  1358 KNKVLYTYAASEDVAALESQPLLGFTVIQVKDENSESKVFQLLHKNMLFYVFKAEDAHSAQKWIE 1422
            |||||||||||||||||||||||||||..||||||||||||||||.|:||||||:||||.|:||:
Mouse  1329 KNKVLYTYAASEDVAALESQPLLGFTVTLVKDENSESKVFQLLHKGMVFYVFKADDAHSTQRWID 1393

Human  1423 AFQEGTIL 1430
            ||||||:|
Mouse  1394 AFQEGTVL 1401

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FGD6	NP_060821.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..36		28/34 (82%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	330..351		15/20 (75%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	516..538		12/21 (57%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	695..739		26/43 (60%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	800..869		56/70 (80%)
		RhoGEF	875..1059	CDD:279015	176/183 (96%)
		PH1_FGD6	1077..1199	CDD:275436	114/123 (93%)
		PH	1092..1183	CDD:278594	84/90 (93%)
		FYVE_FGD6	1217..1277	CDD:277282	57/59 (97%)
		PH	1336..1426	CDD:278594	79/89 (89%)
		PH2_FGD5_FGD6	1336..1424	CDD:270057	77/87 (89%)
Fgd6	XP_036011484.1	RhoGEF	845..1028	CDD:395496	175/182 (96%)
		PH-like	1047..1171	CDD:418428	114/123 (93%)
		FYVE_FGD6	1188..1248	CDD:277282	57/59 (97%)
		PH2_FGD5_FGD6	1307..1395	CDD:270057	77/87 (89%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83959115
Domainoid	1	1.000	973	1.000	Domainoid score	I1806
eggNOG	1	0.900	-	-		E1_KOG1729
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H14209
Inparanoid	1	1.050	2022	1.000	Inparanoid score	I1564
Isobase	1	0.950	-	0	Normalized mean entropy	S6552
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG39709
OrthoDB	1	1.010	-	-		D51685at33208
OrthoFinder	1	1.000	-	-		FOG0010890
OrthoInspector	1	1.000	-	-		oto112832
orthoMCL	1	0.900	-	-		OOG6_105351
Panther	1	1.100	-	-	LDO	PTHR12673
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R11876
SonicParanoid	1	1.000	-	-		X316
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	18	18.290