Protein Alignment TDP1 and tdp1

DIOPT Version :10

• Sequence 1: NP_060789.2
• Gene: TDP1 / 55775
• HGNCID: 18884
• Length: 608
• Species: Homo sapiens
• Sequence 2: NP_001039242.1
• Gene: tdp1 / 734106
• XenbaseID: XB-GENE-950568
• Length: 597
• Species: Xenopus tropicalis
• Alignment Length: 614
• Identity: 395/614 - (64%)
• Similarity: 483/614 - (78%)
• Gaps: 32/614 - (5%)

Human     2 SQEGDYGRWTISSSDESEEEKPKPDKPSTSSLLCARQGAANEPRYTCSEAQKAAHKRKISPVKFS 66
            ||:.:||:||:|||::..|:...|..||:|     |:...:.|.|.||:|:||:||||.:||||.
 Frog     7 SQQSNYGKWTLSSSEDETEDSGIPSPPSSS-----RESRDSVPHYPCSDARKASHKRKANPVKFK 66

Human    67 --NTDSVLPPKRQKSGSQEDLGWCLSSSDDELQP-EMPQK---QAEKV-VIKKEKDISAPNDGTA 124
              :...::|.|:.|: ..|..||||||||:|.:| ::.||   :|:|: |:.:.|.|.
 Frog    67 EMSKKELIPAKKIKT-ETEVSGWCLSSSDEESKPTQVEQKGNIKADKIEVLVQSKKIQ------- 123

Human   125 QRTENHGAPACHRLKEEEDEYETSGEGQDIWDMLDKGNPFQFYLTRVSGVKPKYNSGALHIKDIL 189
               ||        ::.::.:.:|..:.||.||:|..|.||:||||:|.|:|||||||||||||||
 Frog   124 ---EN--------IEVKQKKCKTPSDSQDTWDLLQAGEPFRFYLTKVMGIKPKYNSGALHIKDIL 177

Human   190 SPLFGTLVSSAQFNYCFDVDWLVKQYPPEFRKKPILLVHGDKREAKAHLHAQAKPYENISLCQAK 254
            ||||||||||||||||||:.|||||||.|||.||:|:|||:|||:||.||..|.|||:|.|||||
 Frog   178 SPLFGTLVSSAQFNYCFDIKWLVKQYPEEFRDKPLLIVHGEKRESKAKLHEDAHPYEHIRLCQAK 242

Human   255 LDIAFGTHHTKMMLLLYEEGLRVVIHTSNLIHADWHQKTQGIWLSPLYPRIADGTHKS-GESPTH 318
            |||||||||||||||||.||||||||||||||.||:||||||||||||||:.:|...| |||.|:
 Frog   243 LDIAFGTHHTKMMLLLYTEGLRVVIHTSNLIHEDWYQKTQGIWLSPLYPRLPEGASVSAGESSTN 307

Human   319 FKADLISYLMAYNAPSLKEWIDVIHKHDLSETNVYLIGSTPGRFQGSQKDNWGHFRLKKLLKDHA 383
            |::||::||.:||:|||:||:|:|.:||||||.|||||||||||||:.||.||||||:|||:::.
 Frog   308 FRSDLVAYLASYNSPSLREWMDIIKQHDLSETRVYLIGSTPGRFQGNDKDKWGHFRLRKLLRENT 372

Human   384 SSMPNAESWPVVGQFSSVGSLGADESKWLCSEFKESMLTLGKESKTPGKSSVPLYLIYPSVENVR 448
            |:.|..|:|||:|||||:||:|.|::|||||||.||:.||||..|:..|:.:||:||||||:|||
 Frog   373 SAAPGQETWPVIGQFSSIGSMGVDKTKWLCSEFTESLTTLGKSIKSLQKTEIPLHLIYPSVDNVR 437

Human   449 TSLEGYPAGGSLPYSIQTAEKQNWLHSYFHKWSAETSGRSNAMPHIKTYMRPSPDFSKIAWFLVT 513
            |||||||||||||||||||:||.|||||||||.||||.||.||||||||||.|||...:||||||
 Frog   438 TSLEGYPAGGSLPYSIQTAQKQPWLHSYFHKWKAETSRRSQAMPHIKTYMRLSPDSQHLAWFLVT 502

Human   514 SANLSKAAWGALEKNGTQLMIRSYELGVLFLPSAFGLDSFKVKQKFFAGSQEPMATFPVPYDLPP 578
            ||||||||||:|||||.||.|||||||||||||||..::|.||...:|.::.....|||||||||
 Frog   503 SANLSKAAWGSLEKNGAQLFIRSYELGVLFLPSAFETNTFNVKLNIYASNEPSSNAFPVPYDLPP 567

Human   579 ELYGSKDRPWIWNIPYVKAPDTHGNMWVP 607
            |.||:|||||:||||||.|||||||:|.|
 Frog   568 EHYGAKDRPWVWNIPYVNAPDTHGNIWCP 596

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TDP1	NP_060789.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..101		44/101 (44%)
		Tyr-DNA_phospho	166..582	CDD:461824	311/416 (75%)
		PLD phosphodiesterase 1	258..288		28/29 (97%)
		Interaction with DNA. /evidence=ECO:0000269|PubMed:12470949	400..403		1/2 (50%)
		PLD phosphodiesterase 2	488..521		26/32 (81%)
tdp1	NP_001039242.1	Tyr-DNA_phospho	153..571	CDD:461824	311/417 (75%)