Protein Alignment TDP1 and gkt

DIOPT Version :10

• Sequence 1: NP_060789.2
• Gene: TDP1 / 55775
• HGNCID: 18884
• Length: 608
• Species: Homo sapiens
• Sequence 2: NP_523465.2
• Gene: gkt / 33530
• FlyBaseID: FBgn0260817
• Length: 580
• Species: Drosophila melanogaster
• Alignment Length: 587
• Identity: 201/587 - (34%)
• Similarity: 290/587 - (49%)
• Gaps: 61/587 - (10%)

Human    48 CSEAQKAAHKRKISPVKFSNT--DSVLPPKRQKSGSQEDLGWCLSSSDDELQPEMPQKQAEKVVI 110
            |...:|...|..|...:||:.  |::. .|..:||..| :....||.....|.::.:|...|...
  Fly     4 CPYGEKCYRKNPIHFGEFSHAHLDAIY-AKGNESGDYE-IPANYSSEMIHTQLKLLEKLFPKQAT 66

Human   111 KKEKDI------------------------------SAPNDGTAQRTENHGAPACHRLKEEEDEY 145
            .||::.                              ||.....:|.|.|.........|...|..
  Fly    67 NKEQEAHSSSSKPAVTAPVASGSSSSGSLDTNPSGSSASGPAASQDTSNLAKKQKLNAKNIRDYI 131

Human   146 ETSGEGQDIWDMLDKGNPFQFYLTRVSGVKPKYNSG-ALHIKDILSPLFGTLVSSAQFNYCFDVD 209
            ....|...:...|::..|:..:||.::..||.::.. ::.:::||....|.:.|:.|.|:..|:.
  Fly   132 PVVIEKGGMAKKLERAAPYNMFLTAITDSKPTHSEPLSITLQEILDESLGEIESTVQINFMVDIG 196

Human   210 WLVKQYP-PEFRKKPILLVHGDKREAKAHLHAQAKPYENISLCQAKLDIAFGTHHTKMMLLLYEE 273
            ||:..|. .....||:||::||:   ...|.:..|..:.::..:.|:...|.|.|||||.|.|.:
  Fly   197 WLLGHYYFAGILDKPLLLLYGDE---SPELLSIGKFKQQVTAIRVKMPTPFATSHTKMMFLGYSD 258

Human   274 G-LRVVIHTSNLIHADWHQKTQGIWLSPLYPRI-ADGTHKSGESPTHFKADLISYLMAYNAPSLK 336
            | :||||.|:||...|||.:|||:|:||..|.: .|....:|||.|.||.||:.||:.|....|:
  Fly   259 GSMRVVISTANLYEDDWHNRTQGLWISPKLPALPVDADTGAGESLTGFKQDLMLYLVEYKISQLQ 323

Human   337 EWIDVIHKHDLSETNVYLIGSTP-GRFQGSQKDN-WGHFRLKKLLKDHASSMPNAESWPVVGQFS 399
            .||..|...|.|..||:.:||.| |..:||.:.: |||.||..||..||:  |..:..|||.|.|
  Fly   324 PWIARIRNSDFSAINVFFLGSVPGGHREGSVRGHPWGHARLASLLAKHAA--PIDDRIPVVCQSS 386

Human   400 SVGSLGADESKWLCSEFKESMLTLGKESKTP-GK--SSVPLYLIYPSVENVRTSLEGYPAGGSLP 461
            |:|||||:...|:..:|..|:    |:..|| ||  ...|..:||||..||..|.:|...||.||
  Fly   387 SIGSLGANVQAWIQQDFVNSL----KKDSTPVGKLRQMPPFKMIYPSYGNVAGSHDGMLGGGCLP 447

Human   462 YSIQTAEKQNWLHSYFHKWSAETSGRSNAMPHIKTYMRPSPDFSKIAWFLVTSANLSKAAWGALE 526
            |...|.:||.||..|..:|.:....||.||||||:|.|.:.:...:.||::|||||||||||...
  Fly   448 YGKNTNDKQPWLKDYLQQWKSSDRFRSRAMPHIKSYTRFNLEDQSVYWFVLTSANLSKAAWGCFN 512

Human   527 KNGT---QLMIRSYELGVLFLPS-AFGLDSFKVKQKFFAGSQEPMATFPVPYDLPPELYGSKDRP 587
            ||..   .|.|.:||.||||||. ..|.|:|.:     ..:::.:..||:|||:|...|...|:|
  Fly   513 KNSNIQPCLRIANYEAGVLFLPRFVTGEDTFPL-----GNNRDGVPAFPLPYDVPLTPYAPDDKP 572

Human   588 WI 589
            ::
  Fly   573 FL 574

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TDP1	NP_060789.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..101		14/54 (26%)
		Tyr-DNA_phospho	166..582	CDD:461824	170/428 (40%)
		PLD phosphodiesterase 1	258..288		17/30 (57%)
		Interaction with DNA. /evidence=ECO:0000269|PubMed:12470949	400..403		1/2 (50%)
		PLD phosphodiesterase 2	488..521		18/32 (56%)
gkt	NP_523465.2	zf-CCHH	3..25	CDD:463043	6/20 (30%)
		Tyr-DNA_phospho	152..567	CDD:461824	170/428 (40%)