Protein Alignment TDP1 and Tdp1

DIOPT Version :10

• Sequence 1: NP_060789.2
• Gene: TDP1 / 55775
• HGNCID: 18884
• Length: 608
• Species: Homo sapiens
• Sequence 2: XP_006240494.1
• Gene: Tdp1 / 314380
• RGDID: 1309618
• Length: 625
• Species: Rattus norvegicus
• Alignment Length: 609
• Identity: 500/609 - (82%)
• Similarity: 540/609 - (88%)
• Gaps: 1/609 - (0%)

Human     1 MSQEGDYGRWTISSSDESEEEKPKPDKPSTSSLLCARQGAANEPRYTCSEAQKAAHKRKISPVKF 65
            ||||..||:|||||||:||:|||||.||||||...|.||.:.||.||||||:||||||:||||||
  Rat    17 MSQESSYGKWTISSSDDSEDEKPKPVKPSTSSGPQAGQGVSKEPTYTCSEARKAAHKRQISPVKF 81

Human    66 SNTDSVLPPKRQKSGSQEDLGWCLSSSDDELQPEMPQKQAEKVVIKKEKDIS-APNDGTAQRTEN 129
            :|||||||.|:||..|.|.|||||||||||.||::.|::..|.|..:||..: :.|..|||:.|:
  Rat    82 NNTDSVLPHKKQKMDSPEGLGWCLSSSDDEQQPDVTQQEQPKGVPPQEKKYAPSANVTTAQKVED 146

Human   130 HGAPACHRLKEEEDEYETSGEGQDIWDMLDKGNPFQFYLTRVSGVKPKYNSGALHIKDILSPLFG 194
            ...|..||.:..::|||||||||||||||||.||||||||||||:|.||||.|||||||||||||
  Rat   147 RSPPDSHRAQRADEEYETSGEGQDIWDMLDKENPFQFYLTRVSGIKAKYNSKALHIKDILSPLFG 211

Human   195 TLVSSAQFNYCFDVDWLVKQYPPEFRKKPILLVHGDKREAKAHLHAQAKPYENISLCQAKLDIAF 259
            ||||||||||||||:||:||||||||||||||||||||||||.||||||||.|||||||||||||
  Rat   212 TLVSSAQFNYCFDVNWLIKQYPPEFRKKPILLVHGDKREAKADLHAQAKPYANISLCQAKLDIAF 276

Human   260 GTHHTKMMLLLYEEGLRVVIHTSNLIHADWHQKTQGIWLSPLYPRIADGTHKSGESPTHFKADLI 324
            ||||||||||||||||||||||||||..||||||||||||||||||..|.|.||||.|||||||.
  Rat   277 GTHHTKMMLLLYEEGLRVVIHTSNLIREDWHQKTQGIWLSPLYPRIYQGNHTSGESSTHFKADLT 341

Human   325 SYLMAYNAPSLKEWIDVIHKHDLSETNVYLIGSTPGRFQGSQKDNWGHFRLKKLLKDHASSMPNA 389
            |||||||||.|:||||:|.:|||||||||||||||||||||.|||||||||:|||:.||.|.|..
  Rat   342 SYLMAYNAPPLQEWIDIIQEHDLSETNVYLIGSTPGRFQGSHKDNWGHFRLRKLLQAHAPSAPRG 406

Human   390 ESWPVVGQFSSVGSLGADESKWLCSEFKESMLTLGKESKTPGKSSVPLYLIYPSVENVRTSLEGY 454
            |.|||||||||:||||.|||||||||||||:|.:.:|.:|||:|:|||:||||||||||||||||
  Rat   407 ECWPVVGQFSSIGSLGPDESKWLCSEFKESLLAVREEGRTPGRSAVPLHLIYPSVENVRTSLEGY 471

Human   455 PAGGSLPYSIQTAEKQNWLHSYFHKWSAETSGRSNAMPHIKTYMRPSPDFSKIAWFLVTSANLSK 519
            ||||||||.|||||||.|||.|||||||||||||||||||||||||||||||:||||||||||||
  Rat   472 PAGGSLPYGIQTAEKQRWLHPYFHKWSAETSGRSNAMPHIKTYMRPSPDFSKLAWFLVTSANLSK 536

Human   520 AAWGALEKNGTQLMIRSYELGVLFLPSAFGLDSFKVKQKFFAGSQEPMATFPVPYDLPPELYGSK 584
            ||||||||||.|||||||||||||||||||||:||||||||:.|.||||:|||||||||||||||
  Rat   537 AAWGALEKNGAQLMIRSYELGVLFLPSAFGLDTFKVKQKFFSSSSEPMASFPVPYDLPPELYGSK 601

Human   585 DRPWIWNIPYVKAPDTHGNMWVPS 608
            ||||||||||||||||||||||||
  Rat   602 DRPWIWNIPYVKAPDTHGNMWVPS 625

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TDP1	NP_060789.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..101		74/99 (75%)
		Tyr-DNA_phospho	166..582	CDD:461824	364/415 (88%)
		PLD phosphodiesterase 1	258..288		28/29 (97%)
		Interaction with DNA. /evidence=ECO:0000269|PubMed:12470949	400..403		1/2 (50%)
		PLD phosphodiesterase 2	488..521		31/32 (97%)
Tdp1	XP_006240494.1	Tyr-DNA_phospho	183..599	CDD:461824	364/415 (88%)