Protein Alignment TDP1 and tdpo-1

DIOPT Version :10

• Sequence 1: NP_060789.2
• Gene: TDP1 / 55775
• HGNCID: 18884
• Length: 608
• Species: Homo sapiens
• Sequence 2: NP_500149.1
• Gene: tdpo-1 / 176996
• WormBaseID: WBGene00018678
• Length: 451
• Species: Caenorhabditis elegans
• Alignment Length: 461
• Identity: 160/461 - (34%)
• Similarity: 232/461 - (50%)
• Gaps: 59/461 - (12%)

Human   163 PFQFYLTRVSGVK-PKYNS-GALHIKDILSPLFGTLVSSAQFNYCFDVDWLVKQYPPEFRKKPIL 225
            |...|.|.:.|:. |:..| .:..:.:||:.:  ..::|..|::..|.::|:..|||..|:.||.
 Worm    33 PGSIYFTPIGGISVPRQESESSRSLDEILADI--RPINSLHFSFMLDFEFLIGSYPPSLREYPIT 95

Human   226 LVHG--DKREAKAHLHAQAKPYENISLCQAKLDIAFGTHHTKMMLLLYEEG-LRVVIHTSNLIHA 287
            ||.|  |..:    |....|..:.:::..|.|.|.||||||||.:|..|:| ..|::.|:||:..
 Worm    96 LVVGAPDAPD----LLKCTKNQKLVTVVGASLPIPFGTHHTKMSILEDEDGRFHVIVSTANLVPD 156

Human   288 DWHQKTQGIWLSPLYPRIADGTHKSGESPTHFKADLISYLMAYNAPSLKEWIDVIHKHDLSETNV 352
            ||..|||..:.: ...:||.||....:    |:.||:.||..|. ..|..|..::.|.|.|:.:.
 Worm   157 DWEFKTQQFYYN-FGVKIASGTVPRSD----FQDDLLEYLSMYR-NQLDTWKQLLQKVDFSQISD 215

Human   353 YLIGSTPGRFQGSQKDNWGHFRLKKLLKD---HASSMPNAESWPVVGQFSSVGSLGADESKWLCS 414
            .||.||||..........||.||.::|.:   ..:|..:.|....|.|.||:||||:....|...
 Worm   216 RLIFSTPGYHTDPPTQRPGHPRLFRILSEKFPFDASYEHTERCTFVAQCSSIGSLGSAPINWFRG 280

Human   415 EFKESMLTLGKESKTPGKSSVP--LYLIYPSVENVRTSLEGYPAGGSLPYSIQTAEKQNWLHSYF 477
            :|.:|:     |...|.....|  :||::||||:||||.:||..|.|:||......:|.||....
 Worm   281 QFLQSL-----EGANPSPKQKPAKMYLVFPSVEDVRTSCQGYAGGCSVPYRNSVHARQKWLQGNM 340

Human   478 HKWSAETSGRSNAMPHIKTYMRPSPDFSKIA-WFLVTSANLSKAAWGAL----EKNGTQLMIRSY 537
            .||.:....|:||:||.|||::..   .|:| |.|:|||||||||||.:    .||..||||||:
 Worm   341 CKWRSNAKRRTNAVPHCKTYVKYD---KKVAIWQLLTSANLSKAAWGEVSFNKSKNVEQLMIRSW 402

Human   538 ELGVLFL-PSAFGLDSFKVKQKFFAGSQEPMATFPVPYDLPPELYGSKDRPWIWNIPYVKAPDTH 601
            |:|||.. ||.|.                      :|:|.|...|.:.|.|::.:..:.| ||..
 Worm   403 EMGVLITDPSRFN----------------------IPFDYPLVPYSATDEPFVTDKKHEK-PDIL 444

Human   602 GNMWVP 607
            |.:|.|
 Worm   445 GCIWTP 450

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TDP1	NP_060789.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..101
		Tyr-DNA_phospho	166..582	CDD:461824	150/431 (35%)
		PLD phosphodiesterase 1	258..288		15/30 (50%)
		Interaction with DNA. /evidence=ECO:0000269|PubMed:12470949	400..403		1/2 (50%)
		PLD phosphodiesterase 2	488..521		18/33 (55%)
tdpo-1	NP_500149.1	PLDc_SF	32..194	CDD:472788	56/171 (33%)
		PLDc_mTdp1_2	215..410	CDD:197291	83/202 (41%)