Protein Alignment TDP1 and Tdp1

DIOPT Version :10

• Sequence 1: NP_060789.2
• Gene: TDP1 / 55775
• HGNCID: 18884
• Length: 608
• Species: Homo sapiens
• Sequence 2: XP_030102366.1
• Gene: Tdp1 / 104884
• MGIID: 1920036
• Length: 672
• Species: Mus musculus
• Alignment Length: 549
• Identity: 442/549 - (80%)
• Similarity: 483/549 - (87%)
• Gaps: 1/549 - (0%)

Human     1 MSQEGDYGRWTISSSDESEEEKPKPDKPSTSSLLCARQGAANEPRYTCSEAQKAAHKRKISPVKF 65
            ||||..||:||||||||||:|||||||||.||...|.||.:.|..||||||:|.||||:||||||
Mouse     5 MSQESSYGKWTISSSDESEDEKPKPDKPSASSHPQAGQGVSKELIYTCSEARKVAHKRQISPVKF 69

Human    66 SNTDSVLPPKRQKSGSQEDLGWCLSSSDDELQPEMPQKQAEKVVIKKE-KDISAPNDGTAQRTEN 129
            ::.|||||.|:|||.|.|.||||||||||:.||::.|::..|.|:.:| |.:|:|:..|||:..:
Mouse    70 NDADSVLPHKKQKSDSPEGLGWCLSSSDDDQQPDVTQQEQPKRVLPQEKKHVSSPDVTTAQKVVD 134

Human   130 HGAPACHRLKEEEDEYETSGEGQDIWDMLDKGNPFQFYLTRVSGVKPKYNSGALHIKDILSPLFG 194
            ...||..|.:..:|||||||||||||||||||||||||||||||:|.||||.|||||||||||||
Mouse   135 RSPPASLRPQRADDEYETSGEGQDIWDMLDKGNPFQFYLTRVSGIKAKYNSKALHIKDILSPLFG 199

Human   195 TLVSSAQFNYCFDVDWLVKQYPPEFRKKPILLVHGDKREAKAHLHAQAKPYENISLCQAKLDIAF 259
            |||||||||||||||||:|||||||||.||||||||||||||.||||||||.|||||||||||||
Mouse   200 TLVSSAQFNYCFDVDWLIKQYPPEFRKNPILLVHGDKREAKADLHAQAKPYANISLCQAKLDIAF 264

Human   260 GTHHTKMMLLLYEEGLRVVIHTSNLIHADWHQKTQGIWLSPLYPRIADGTHKSGESPTHFKADLI 324
            ||||||||||||||||||||||||||..||||||||||||||||||..|:|.:|||.|.|||||.
Mouse   265 GTHHTKMMLLLYEEGLRVVIHTSNLIREDWHQKTQGIWLSPLYPRIDQGSHTAGESSTRFKADLT 329

Human   325 SYLMAYNAPSLKEWIDVIHKHDLSETNVYLIGSTPGRFQGSQKDNWGHFRLKKLLKDHASSMPNA 389
            |||.|||||.|:||||:|.:|||||||||||||||||||||.:||||||||:|||:.||.|.|..
Mouse   330 SYLTAYNAPPLQEWIDIIQEHDLSETNVYLIGSTPGRFQGSHRDNWGHFRLRKLLQAHAPSTPKG 394

Human   390 ESWPVVGQFSSVGSLGADESKWLCSEFKESMLTLGKESKTPGKSSVPLYLIYPSVENVRTSLEGY 454
            |.||:||||||:||||.|||||||||||:|:|.|.:|.:.||||:|||:||||||||||||||||
Mouse   395 ECWPIVGQFSSIGSLGPDESKWLCSEFKDSLLALREEGRPPGKSAVPLHLIYPSVENVRTSLEGY 459

Human   455 PAGGSLPYSIQTAEKQNWLHSYFHKWSAETSGRSNAMPHIKTYMRPSPDFSKIAWFLVTSANLSK 519
            ||||||||||||||||.|||||||||||||||||||||||||||||||||||:||||||||||||
Mouse   460 PAGGSLPYSIQTAEKQRWLHSYFHKWSAETSGRSNAMPHIKTYMRPSPDFSKLAWFLVTSANLSK 524

Human   520 AAWGALEKNGTQLMIRSYELGVLFLPSAF 548
            |||||||||||||||||||||||||||||
Mouse   525 AAWGALEKNGTQLMIRSYELGVLFLPSAF 553

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TDP1	NP_060789.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..101		71/99 (72%)
		Tyr-DNA_phospho	166..582	CDD:461824	335/383 (87%)
		PLD phosphodiesterase 1	258..288		28/29 (97%)
		Interaction with DNA. /evidence=ECO:0000269|PubMed:12470949	400..403		1/2 (50%)
		PLD phosphodiesterase 2	488..521		31/32 (97%)
Tdp1	XP_030102366.1	Tyr-DNA_phospho	171..553	CDD:461824	333/381 (87%)