DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PRKAR2B and prkar2b

DIOPT Version :9

Sequence 1:	NP_002727.2	Gene:	PRKAR2B / 5577	HGNCID:	9392	Length:	418	Species:	Homo sapiens
Sequence 2:	XP_017209716.1	Gene:	prkar2b / 100331387	-ID:	-	Length:	403	Species:	Danio rerio

Alignment Length:	419	Identity:	309/419 - (73%)
Similarity:	345/419 - (82%)	Gaps:	17/419 - (4%)

- Green bases have known domain annotations that are detailed below.

Human     1 MSIEIPAGLTELLQGFTVEVLRHQPADLLEFALQHFTRLQQENERKGTARFGHEGRTWGDLGAAA 65
            ||||||.|||||||.|||||||:|||||||||||:|||| :|||.:|.| ||:|...     |..
Zfish     1 MSIEIPEGLTELLQSFTVEVLRNQPADLLEFALQYFTRL-KENETRGGA-FGNERNP-----ATR 58

Human    66 GGGTPSKGVNFAEEPMQSDSEDGEEEEAAPADAGAFNAPVINRFTRRASVCAEAYNPDEEEDDAE 130
            .|    |.|||.||.||.|||:||||:    |...|.|||||||.||||||||||||||:|::.|
Zfish    59 AG----KAVNFIEEAMQIDSENGEEED----DDEEFVAPVINRFVRRASVCAEAYNPDEDEEERE 115

Human   131 SRIIHPKTDDQRNRLQEACKDILLFKNLDPEQMSQVLDAMFEKLVKDGEHVIDQGDDGDNFYVID 195
            .|:.:||||:||.||||||||||||||||.|||||||||||||:|..|||:|||.|||||||||:
Zfish   116 PRVTYPKTDEQRQRLQEACKDILLFKNLDQEQMSQVLDAMFEKVVVSGEHIIDQDDDGDNFYVIE 180

Human   196 RGTFDIYVKCDGVGRCVGNYDNRGSFGELALMYNTPRAATITATSPGALWGLDRVTFRRIIVKNN 260
            ||.|:|.:|.||..|.||:||||||||||||||||||||||.||||||||.|||:||||||||||
Zfish   181 RGMFEILLKADGTTRTVGSYDNRGSFGELALMYNTPRAATIIATSPGALWCLDRLTFRRIIVKNN 245

Human   261 AKKRKMYESFIESLPFLKSLEFSERLKVVDVIGTKVYNDGEQIIAQGDSADSFFIVESGEVKITM 325
            ||||||||:||.:||.|.|||.|||:|||||:.|||||.|||||||||.||.|:|||||.|:|||
Zfish   246 AKKRKMYEAFIGTLPLLTSLEVSERMKVVDVLSTKVYNGGEQIIAQGDLADCFYIVESGHVRITM 310

Human   326 KR-KGKSEVEENGAVEIARCSRGQYFGELALVTNKPRAASAHAIGTVKCLAMDVQAFERLLGPCM 389
            || |.|::.|:. .||||.||||||||||||||||||||||:|:.:||||.||||||||||||||
Zfish   311 KRSKSKNDTEDE-EVEIATCSRGQYFGELALVTNKPRAASAYAMDSVKCLVMDVQAFERLLGPCM 374

Human   390 EIMKRNIATYEEQLVALFGTNMDIVEPTA 418
            :|||||||.|||||:.|||:.:.|.||.|
Zfish   375 DIMKRNIANYEEQLITLFGSQIAIEEPNA 403

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PRKAR2B	NP_002727.2	Dimerization and phosphorylation	2..153		99/150 (66%)
		DD_RIIbeta_PKA	3..43	CDD:213051	33/39 (85%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	48..96		21/47 (45%)
		Crp	150..>259	CDD:223736	89/108 (82%)
		CAP_ED	154..267	CDD:237999	93/112 (83%)
		Crp	270..>385	CDD:223736	86/115 (75%)
		CAP_ED	276..396	CDD:237999	92/120 (77%)
prkar2b	XP_017209716.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194339751
Domainoid	1	1.000	141	1.000	Domainoid score	I19131
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H37666
Inparanoid	1	1.050	555	1.000	Inparanoid score	I5816
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG54324
OrthoDB	1	1.010	-	-		D1047290at2759
OrthoFinder	1	1.000	-	-		FOG0000531
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100449
Panther	1	1.100	-	-	LDO	PTHR11635
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2591
SonicParanoid	1	1.000	-	-		X421
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	15	14.940