Protein Alignment NGLY1 and PNG1

DIOPT Version :10

• Sequence 1: NP_060767.2
• Gene: NGLY1 / 55768
• HGNCID: 17646
• Length: 654
• Species: Homo sapiens
• Sequence 2: NP_015229.1
• Gene: PNG1 / 856009
• SGDID: S000006017
• Length: 363
• Species: Saccharomyces cerevisiae
• Alignment Length: 309
• Identity: 118/309 - (38%)
• Similarity: 170/309 - (55%)
• Gaps: 21/309 - (6%)

Human   180 QHV-LVYENPALQEKALACIPVQELKRKSQEKLSRARKLDKGINISDEDFLLLELLHWFKEEFFH 243
            ||: .||:||:.....|..:.:..:.:...::.::....: |.||. .|:|:.|||.:||::||.
Yeast    60 QHLCTVYDNPSWHSIVLETLDLDLIYKNVDKEFAKDGHAE-GENIY-TDYLVKELLRYFKQDFFK 122

Human   244 WVNNVLCSKCGGQTRSRDRSLL----PSDDELKWGAKEVEDHYCDACQFSNRFPRYNNPEKLLET 304
            |.|...|:.| ||..|.:.:.|    |:.:|.|:....||.:.|:.|....||||||:|.|||||
Yeast   123 WCNKPDCNHC-GQNTSENMTPLGSQGPNGEESKFNCGTVEIYKCNRCGNITRFPRYNDPIKLLET 186

Human   305 RCGRCGEWANCFTLCCRAVGFEARYVWDYTDHVWTEVYSPSQQRWLHCDACEDVCDKPLLYEIGW 369
            |.||||||.|.|||..::.|.:.||||:..||||.|.:|....||:|.|:||...|:|.:|.|.|
Yeast   187 RKGRCGEWCNLFTLILKSFGLDVRYVWNREDHVWCEYFSNFLNRWVHVDSCEQSFDQPYIYSINW 251

Human   370 GKKLSYVIAFSKDEVVDVTWRYSCKHEEVIARRTKVKEALLRDTINGLNKQRQLFLSENRRKELL 434
            .||:||.|||.||.||||:.||..::|   ..|.::||..|:.....:.|:.:..|:::...:|.
Yeast   252 NKKMSYCIAFGKDGVVDVSKRYILQNE---LPRDQIKEEDLKFLCQFITKRLRYSLNDDEIYQLA 313

Human   435 QRIIVELVEFISPKTPK----------PGELGGRISGSVAWRVARGEMG 473
            .|...|.:|.|..||.:          .....||.|||..|:..|||.|
Yeast   314 CRDEQEQIELIRGKTQETKSESVSAASKSSNRGRESGSADWKAQRGEDG 362

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NGLY1	NP_060767.2	PUB_PNGase	19..109	CDD:198417
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	112..163
		Transglut_core	275..354	CDD:376628	41/78 (53%)
		Rad4	<338..>392	CDD:427539	28/53 (53%)
		PAW	457..651	CDD:461409	10/17 (59%)
PNG1	NP_015229.1	TGc	183..237	CDD:214673	30/53 (57%)
		Rad4	<220..>274	CDD:427539	28/53 (53%)