Protein Alignment NGLY1 and Ngly1

DIOPT Version :10

• Sequence 1: NP_060767.2
• Gene: NGLY1 / 55768
• HGNCID: 17646
• Length: 654
• Species: Homo sapiens
• Sequence 2: NP_067479.2
• Gene: Ngly1 / 59007
• MGIID: 1913276
• Length: 651
• Species: Mus musculus
• Alignment Length: 654
• Identity: 553/654 - (84%)
• Similarity: 599/654 - (91%)
• Gaps: 3/654 - (0%)

Human     1 MAAAALGSSSGSASPAVAELCQNTPETFLEASKLLLTYADNILRNPNDEKYRSIRIGNTAFSTRL 65
            ||:|.|||||.|||||||||||||||||||||||||||||||||||:||||||||||||||||||
Mouse     1 MASATLGSSSSSASPAVAELCQNTPETFLEASKLLLTYADNILRNPSDEKYRSIRIGNTAFSTRL 65

Human    66 LPVRGAVECLFEMGFEEGETHLIFPKKASVEQLQKIRDLIAIERSSRLDGSNKSHKVKSSQQPAA 130
            |||||||||||||||||||||||||||||||||||||||||||||||||||:|  ||:.||.|||
Mouse    66 LPVRGAVECLFEMGFEEGETHLIFPKKASVEQLQKIRDLIAIERSSRLDGSSK--KVQFSQHPAA 128

Human   131 STQLPTTPSSNPSGLNQHTRNRQGQSSDPPSASTVAADSAILEVLQSNIQHVLVYENPALQEKAL 195
            : :||...|.:|:||.:|:.|:.||....|||..|..||.||:|||||||||.:||||.||||||
Mouse   129 A-KLPLEQSEDPAGLIRHSGNQTGQLPSLPSAPMVVGDSTILKVLQSNIQHVQLYENPVLQEKAL 192

Human   196 ACIPVQELKRKSQEKLSRARKLDKGINISDEDFLLLELLHWFKEEFFHWVNNVLCSKCGGQTRSR 260
            .||||.|||||:||||.||||||||.|:|||||||||||||||||||.||||::||||||:||||
Mouse   193 TCIPVSELKRKAQEKLFRARKLDKGTNVSDEDFLLLELLHWFKEEFFRWVNNIVCSKCGGETRSR 257

Human   261 DRSLLPSDDELKWGAKEVEDHYCDACQFSNRFPRYNNPEKLLETRCGRCGEWANCFTLCCRAVGF 325
            |.:|||:|||||||||.||:|||||||.||||||||||||||||||||||||||||||||||:||
Mouse   258 DEALLPNDDELKWGAKNVENHYCDACQLSNRFPRYNNPEKLLETRCGRCGEWANCFTLCCRALGF 322

Human   326 EARYVWDYTDHVWTEVYSPSQQRWLHCDACEDVCDKPLLYEIGWGKKLSYVIAFSKDEVVDVTWR 390
            ||||||||||||||||||||||||||||||||||||||||||||||||||:||||||||||||||
Mouse   323 EARYVWDYTDHVWTEVYSPSQQRWLHCDACEDVCDKPLLYEIGWGKKLSYIIAFSKDEVVDVTWR 387

Human   391 YSCKHEEVIARRTKVKEALLRDTINGLNKQRQLFLSENRRKELLQRIIVELVEFISPKTPKPGEL 455
            |||||:||::|||||||.|||:|||||||||||.|||:||||||||||||||||||||||:||||
Mouse   388 YSCKHDEVMSRRTKVKEELLRETINGLNKQRQLSLSESRRKELLQRIIVELVEFISPKTPRPGEL 452

Human   456 GGRISGSVAWRVARGEMGLQRKETLFIPCENEKISKQLHLCYNIVKDRYVRVSNNNQTISGWENG 520
            |||:|||:||||||||.||:|||.||||.||||||||.||.|:||:|||:|||:||..|||||||
Mouse   453 GGRVSGSLAWRVARGETGLERKEILFIPSENEKISKQFHLRYDIVRDRYIRVSDNNINISGWENG 517

Human   521 VWKMESIFRKVETDWHMVYLARKEGSSFAYISWKFECGSVGLKVDSISIRTSSQTFQTGTVEWKL 585
            ||||||||||||.||:|||||||||||||||||||||||.|||||::|||||||:|::|:|.|||
Mouse   518 VWKMESIFRKVEKDWNMVYLARKEGSSFAYISWKFECGSAGLKVDTVSIRTSSQSFESGSVRWKL 582

Human   586 RSDTAQVELTGDNSLHSYADFSGATEVILEAELSRGDGDVAWQHTQLFRQSLNDHEENCLEIIIK 650
            ||:||||.|.||.:|.||.||||||||.||||||||||||||||||||||||||..||.|||||.
Mouse   583 RSETAQVNLLGDKNLRSYNDFSGATEVTLEAELSRGDGDVAWQHTQLFRQSLNDSGENGLEIIIT 647

Human   651 FSDL 654
            |:||
Mouse   648 FNDL 651

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NGLY1	NP_060767.2	PUB_PNGase	19..109	CDD:198417	88/89 (99%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	112..163		25/50 (50%)
		Transglut_core	275..354	CDD:376628	74/78 (95%)
		Rad4	<338..>392	CDD:427539	52/53 (98%)
		PAW	457..651	CDD:461409	158/193 (82%)
Ngly1	NP_067479.2	PUB_PNGase	19..109	CDD:198417	88/89 (99%)
		Transglut_core	272..351	CDD:376628	74/78 (95%)
		Rad4	<335..>389	CDD:427539	52/53 (98%)
		PAW	454..648	CDD:461409	158/193 (82%)