Protein Alignment NGLY1 and ngly1

DIOPT Version :10

• Sequence 1: NP_060767.2
• Gene: NGLY1 / 55768
• HGNCID: 17646
• Length: 654
• Species: Homo sapiens
• Sequence 2: NP_001018437.1
• Gene: ngly1 / 553627
• ZFINID: ZDB-GENE-050522-535
• Length: 644
• Species: Danio rerio
• Alignment Length: 642
• Identity: 371/642 - (57%)
• Similarity: 471/642 - (73%)
• Gaps: 10/642 - (1%)

Human    14 SPAVAELCQNTPETFLEASKLLLTYADNILRNPNDEKYRSIRIGNTAFSTRLLPVRGAVECLFEM 78
            |..|..||:||.|.||:.||||:|||||||||||:||||||||||..|||:||||:|||||||||
Zfish     4 SQGVLALCENTTEVFLDVSKLLITYADNILRNPNEEKYRSIRIGNPTFSTKLLPVKGAVECLFEM 68

Human    79 GFEEGETHLIFPKKASVEQLQKIRDLIAIERSSRLDGSNKSHKVKSSQQPAASTQLPTTPSSNPS 143
            ||||.||||:||:.||||:|:::|:.||.||..||..||.:    ||.|.|:...:|..|.|..|
Zfish    69 GFEEAETHLVFPRSASVEKLRQVRETIAAERDQRLGASNTA----SSPQNASVPPVPAPPPSLSS 129

Human   144 GLNQHTRNRQGQSSDPPSASTVAADSAILEVLQSNIQHVLVYENPALQEKALACIPVQELKRKSQ 208
            ..:.........:..|.|....::.:.....:|||.|||||||:|.||:|||.|||.:.|:.:::
Zfish   130 TASAGPAAAAVPTPAPASIPFTSSSATFQRTVQSNFQHVLVYEDPELQQKALECIPHELLRSRAK 194

Human   209 EKLSRARKLDKGINISDEDFLLLELLHWFKEEFFHWVNNVLCSKCGGQTRSRDRSLLPSDDELKW 273
            |:|.:|...|...::.:||.|:|:||.|||.:||.||:|:.|.:|||:|:. ..||.||.|:|.|
Zfish   195 ERLKQANDADAACSLGEEDMLVLDLLQWFKSDFFSWVDNLPCIQCGGKTQP-SGSLSPSSDDLHW 258

Human   274 GAKEVEDHYCDACQFSNRFPRYNNPEKLLETRCGRCGEWANCFTLCCRAVGFEARYVWDYTDHVW 338
            .|..||:|:|..||.|.|||||||||||||||.||||||||||||.|||:|.||||:||.|||||
Zfish   259 DAGRVENHFCHTCQLSTRFPRYNNPEKLLETRKGRCGEWANCFTLLCRALGLEARYIWDSTDHVW 323

Human   339 TEVYSPSQQRWLHCDACEDVCDKPLLYEIGWGKKLSYVIAFSKDEVVDVTWRYSCKHEEVIARRT 403
            |||||.||:||:|||.||:.||||||||:||||||||::|||||:|.||||||||||.||::|||
Zfish   324 TEVYSQSQRRWIHCDPCENACDKPLLYEVGWGKKLSYILAFSKDQVADVTWRYSCKHPEVLSRRT 388

Human   404 KVKEALLRDTINGLNKQRQLFLSENRRKELLQRIIVELVEFISPKTPKPGELGGRISGSVAWRVA 468
            :|:|..|...:|.||.:||.||...|:::||||::||||||||||:|:|||||||:|||:|||.|
Zfish   389 QVQETWLLHMLNKLNAERQQFLGAERKQQLLQRLLVELVEFISPKSPQPGELGGRMSGSLAWRAA 453

Human   469 RGEMGLQR-----KETLFIPCENEKISKQLHLCYNIVKDRYVRVSNNNQTISGWENGVWKMESIF 528
            |||.|...     :|.:|.|.|:||.||:.|:|||:.||.|.||||..:||.||:.|.|:.|::|
Zfish   454 RGETGASNAKEDTQENVFTPSESEKESKRFHICYNVTKDCYYRVSNGQETIQGWQKGAWRTENMF 518

Human   529 RKVETDWHMVYLARKEGSSFAYISWKFECGSVGLKVDSISIRTSSQTFQTGTVEWKLRSDTAQVE 593
            ||.|.||.||||||.||:||..:||||.|...|:|:.|.|:|..||||.:|||.|.|.::....|
Zfish   519 RKEEHDWQMVYLARTEGASFGRMSWKFNCAPAGMKMKSASVRVFSQTFHSGTVRWSLSTNETTTE 583

Human   594 LTGDNSLHSYADFSGATEVILEAELSRGDGDVAWQHTQLFRQSLNDHEENCLEIIIK 650
            ..||..|||:::.||.||:|:||||:.|||..:|||.|||||||.|.|:...|::::
Zfish   584 FPGDGELHSFSNVSGGTELIVEAELTGGDGSTSWQHAQLFRQSLKDTEKVLFEVMVE 640

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NGLY1	NP_060767.2	PUB_PNGase	19..109	CDD:198417	66/89 (74%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	112..163		14/50 (28%)
		Transglut_core	275..354	CDD:376628	61/78 (78%)
		Rad4	<338..>392	CDD:427539	42/53 (79%)
		PAW	457..651	CDD:461409	105/199 (53%)
ngly1	NP_001018437.1	PUB_PNGase	7..99	CDD:198417	67/91 (74%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	98..141		14/46 (30%)
		Transglut_core	262..339	CDD:376628	60/76 (79%)
		Rad4	<323..>377	CDD:427539	42/53 (79%)
		PAW	442..641	CDD:461409	105/199 (53%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	455..474		5/18 (28%)