DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment NGLY1 and Ngly1

DIOPT Version :10

Sequence 1:NP_060767.2 Gene:NGLY1 / 55768 HGNCID:17646 Length:654 Species:Homo sapiens
Sequence 2:NP_001401916.1 Gene:Ngly1 / 361014 RGDID:1308518 Length:651 Species:Rattus norvegicus


Alignment Length:654 Identity:552/654 - (84%)
Similarity:591/654 - (90%) Gaps:3/654 - (0%)


- Green bases have known domain annotations that are detailed below.


Human     1 MAAAALGSSSGSASPAVAELCQNTPETFLEASKLLLTYADNILRNPNDEKYRSIRIGNTAFSTRL 65
            ||:|.|||||.|||||||||||||||||||||||||||||||||||:||||||||||||||||||
  Rat     1 MASATLGSSSSSASPAVAELCQNTPETFLEASKLLLTYADNILRNPSDEKYRSIRIGNTAFSTRL 65

Human    66 LPVRGAVECLFEMGFEEGETHLIFPKKASVEQLQKIRDLIAIERSSRLDGSNKSHKVKSSQQPAA 130
            |||||||||||||||||||||||||||||||||||||||||:||.||||||  |.||:.||.|||
  Rat    66 LPVRGAVECLFEMGFEEGETHLIFPKKASVEQLQKIRDLIAVERRSRLDGS--SQKVEFSQHPAA 128

Human   131 STQLPTTPSSNPSGLNQHTRNRQGQSSDPPSASTVAADSAILEVLQSNIQHVLVYENPALQEKAL 195
             .:||.....:|:||.||:.|:.||....|||..|..||.|.:|||||||||.:||||.||||||
  Rat   129 -VRLPAEQPEDPTGLMQHSGNQPGQPLSLPSAPLVVGDSTIFKVLQSNIQHVQLYENPVLQEKAL 192

Human   196 ACIPVQELKRKSQEKLSRARKLDKGINISDEDFLLLELLHWFKEEFFHWVNNVLCSKCGGQTRSR 260
            |||||.||||||||||.||||||||..:|||||||||||||||||||||||||:||:||.:||||
  Rat   193 ACIPVNELKRKSQEKLFRARKLDKGTKVSDEDFLLLELLHWFKEEFFHWVNNVVCSRCGRETRSR 257

Human   261 DRSLLPSDDELKWGAKEVEDHYCDACQFSNRFPRYNNPEKLLETRCGRCGEWANCFTLCCRAVGF 325
            |.:|.|:|||||||||.||||||||||.||||||||||||||||||||||||||||||||||:||
  Rat   258 DEALPPNDDELKWGAKNVEDHYCDACQLSNRFPRYNNPEKLLETRCGRCGEWANCFTLCCRALGF 322

Human   326 EARYVWDYTDHVWTEVYSPSQQRWLHCDACEDVCDKPLLYEIGWGKKLSYVIAFSKDEVVDVTWR 390
            ||||||||||||||||||||||||||||||||||||||||||||||||||:||||||||||||||
  Rat   323 EARYVWDYTDHVWTEVYSPSQQRWLHCDACEDVCDKPLLYEIGWGKKLSYIIAFSKDEVVDVTWR 387

Human   391 YSCKHEEVIARRTKVKEALLRDTINGLNKQRQLFLSENRRKELLQRIIVELVEFISPKTPKPGEL 455
            ||||||||::|||||||.|||:|||||||||||.|||:||||||||||||||||||||||:||||
  Rat   388 YSCKHEEVMSRRTKVKEELLRETINGLNKQRQLLLSESRRKELLQRIIVELVEFISPKTPRPGEL 452

Human   456 GGRISGSVAWRVARGEMGLQRKETLFIPCENEKISKQLHLCYNIVKDRYVRVSNNNQTISGWENG 520
            |||:|||:||||||||..|:|||.||||.||||||||.||.|:||:|||:|||:||..|||||||
  Rat   453 GGRVSGSLAWRVARGETCLERKEILFIPSENEKISKQFHLRYDIVRDRYIRVSDNNANISGWENG 517

Human   521 VWKMESIFRKVETDWHMVYLARKEGSSFAYISWKFECGSVGLKVDSISIRTSSQTFQTGTVEWKL 585
            ||||||||||||.||:|||||||||||||||||||||||.|||||::|||||||:|:||:|.|||
  Rat   518 VWKMESIFRKVEKDWNMVYLARKEGSSFAYISWKFECGSAGLKVDNVSIRTSSQSFETGSVRWKL 582

Human   586 RSDTAQVELTGDNSLHSYADFSGATEVILEAELSRGDGDVAWQHTQLFRQSLNDHEENCLEIIIK 650
            ||:.|||.|.||.:|.||.||.|||||.|||||||||||||||||||||||||||.||.|||||.
  Rat   583 RSEMAQVNLLGDRNLRSYDDFCGATEVTLEAELSRGDGDVAWQHTQLFRQSLNDHAENGLEIIIT 647

Human   651 FSDL 654
            ||||
  Rat   648 FSDL 651

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NGLY1NP_060767.2 PUB_PNGase 19..109 CDD:198417 87/89 (98%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 112..163 25/50 (50%)
Transglut_core 275..354 CDD:376628 75/78 (96%)
Rad4 <338..>392 CDD:427539 52/53 (98%)
PAW 457..651 CDD:461409 157/193 (81%)
Ngly1NP_001401916.1 PUB_PNGase 19..109 CDD:198417 87/89 (98%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 116..153 18/39 (46%)
Transglut_core 272..351 CDD:376628 75/78 (96%)
Rad4 <335..>389 CDD:427539 52/53 (98%)
PAW 454..648 CDD:461409 157/193 (81%)

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