Protein Alignment NGLY1 and ngl1

DIOPT Version :10

• Sequence 1: NP_060767.2
• Gene: NGLY1 / 55768
• HGNCID: 17646
• Length: 654
• Species: Homo sapiens
• Sequence 2: NP_595447.1
• Gene: ngl1 / 2539952
• PomBaseID: SPBC1709.14
• Length: 333
• Species: Schizosaccharomyces pombe
• Alignment Length: 334
• Identity: 136/334 - (40%)
• Similarity: 195/334 - (58%)
• Gaps: 26/334 - (7%)

Human   149 TRNRQGQSSDPPSASTVAADSAILEVLQSNIQHVLVYENPALQEKALACIPVQELKRKSQEKLSR 213
            ::|.| .:|.||.....     ..||.|.: ||..:||:|.||:.||:.:|:.:|.:.:.|
pombe    16 SKNSQ-NASQPPETYPF-----YHEVRQMS-QHPWMYEDPELQDYALSILPLDKLFQDASE---- 69

Human   214 ARKLDKGINIS--DEDFLLLELLHWFKEEFFHWVNNVLCSKCGGQTRSRDRSLLPSDDELKW-GA 275
               |:|..:.|  .:|:::..||.|||.|||.|||...|.||||:|......  |.::|.|| |.
pombe    70 ---LEKEGDGSWGYQDYVIQALLKWFKREFFVWVNQPPCEKCGGETHMTGNG--PPNEEEKWNGV 129

Human   276 KEVEDHYCDACQFSNRFPRYNNPEKLLETRCGRCGEWANCFTLCCRAVGFEARYVWDYTDHVWTE 340
            :.||.:.|:.|..:.||||||....||::|.|||||||||||..|||:|..||::|:..||||||
pombe   130 RNVELYQCNVCGHNQRFPRYNRIRALLDSRKGRCGEWANCFTFLCRALGSRARWIWNAEDHVWTE 194

Human   341 VYSPSQQRWLHCDACEDVCDKPLLYEIGWGKKLSYVIAFSKDEVVDVTWRYSCKHEEVIARRTKV 405
            |||..||||:|.|:.|:..|:||:||.|||||:||.:.|..|.|.||:.|| .:|.|....|.:.
pombe   195 VYSNKQQRWVHVDSGEESFDEPLIYEQGWGKKMSYCLGFGIDSVRDVSHRY-IRHPENGLPRDRC 258

Human   406 KEALLRDTINGLNKQRQLFLSENRRKELLQRIIVELVEF------ISPKTPKPGELGGRISGSVA 464
            .|::|:..::.:|.:.:..|:::.||.|.:....|..|.      :|..||...:|..|.:|:|.
pombe   259 PESVLQQALHEINIEFRSRLTDSERKALEEEDKREKDELDGYMRPVSQATPTNTDLPARQTGNVE 323

Human   465 WRVARGEMG 473
            |:..|||.|
pombe   324 WKEKRGEAG 332

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NGLY1	NP_060767.2	PUB_PNGase	19..109	CDD:198417
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	112..163		5/13 (38%)
		Transglut_core	275..354	CDD:376628	45/78 (58%)
		Rad4	<338..>392	CDD:427539	31/53 (58%)
		PAW	457..651	CDD:461409	8/17 (47%)
ngl1	NP_595447.1	Transglut_core	118..207	CDD:376628	50/90 (56%)
		Rad4	<192..>248	CDD:427539	32/56 (57%)