DRSC/TRiP Functional Genomics Resources

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Protein Alignment NGLY1 and png-1

DIOPT Version :10

Sequence 1:NP_060767.2 Gene:NGLY1 / 55768 HGNCID:17646 Length:654 Species:Homo sapiens
Sequence 2:NP_492913.1 Gene:png-1 / 173028 WormBaseID:WBGene00010160 Length:606 Species:Caenorhabditis elegans


Alignment Length:525 Identity:187/525 - (35%)
Similarity:274/525 - (52%) Gaps:61/525 - (11%)


- Green bases have known domain annotations that are detailed below.


Human   144 GLNQHT---RNRQGQSSDP--PSASTVAADS--AILE--VLQSNIQHVLVYENPALQEKALACIP 199
            |.||..   :.||..|..|  |:|   |:||  ..||  |..||:..  .|::...:..|.:.:|
 Worm    93 GANQQAIAEKIRQHYSPTPANPNA---ASDSEKRFLEQFVKCSNVPR--SYQDEVFKALARSVMP 152

Human   200 VQELKRKSQEKLSRARKLDKGINISDEDFLLLELLHWFKEEFFHWVNNVLCSKCGGQTRSRDRSL 264
                    :|.:.||  :.:|..  ||..:|.:||||||.:||.|.:...|.||..:..:.....
 Worm   153 --------EELVGRA--MTEGPR--DEKAILKDLLHWFKTQFFTWFDRPTCPKCTLKCSTDGLQG 205

Human   265 LPSDDELK-WGAKEVEDHYCDACQFSNRFPRYNNPEKLLETRCGRCGEWANCFTLCCRAVGFEAR 328
            .|:.:|.| .||..||.:.||.|....||||||||.|||:||.||||||||||.|...|:..|:|
 Worm   206 TPTREEQKEGGASRVEVYICDGCNTEMRFPRYNNPAKLLQTRTGRCGEWANCFGLLLAALNLESR 270

Human   329 YVWDYTDHVWTEVYSPSQQRWLHCDACEDVCDKPLLYEIGWGKKLSYVIAFSKDEVVDVTWRYSC 393
            :::|.|||||.|||..::|||.|.|.||:..|:||||..||||.|.|.|.:..|.||||||||..
 Worm   271 FIYDTTDHVWNEVYLLAEQRWCHVDPCENTMDRPLLYTRGWGKTLGYCIGYGSDHVVDVTWRYIW 335

Human   394 KHEEVIARRTKVKEALLRDTINGLNKQRQLFLSENRRKELLQRIIVELVEFIS--PKTPKPG--- 453
            ..::::.:|.:|::.:..:.::.||.::....:|.|::||..|.:.||:|.::  .|..|.|   
 Worm   336 DSKKLVTQRNEVRQPVFENFLSKLNSRQAEGQTEPRKRELAVRRVCELMEMMAQEAKNHKIGWEK 400

Human   454 ---ELGGRISGSVAWRVARGEMGLQRKETLFIPCE----NEKISKQLHLCYNIVKDRYVRVSNNN 511
               :|||||:||..||..|||:|....:.|..|.:    .......|...|:::.|.|     :.
 Worm   401 IGDDLGGRITGSEEWRRERGELGESGPKLLAEPIKLAPPTGPAQNYLEFNYDVITDTY-----SQ 460

Human   512 QTISGWENGVWKMESIFRKVETDWHMVYLARKEGSSFAYISWKFECGSVGLKVDSISIRTSS-QT 575
            ....|:....:::|::.|..||||:|.||.||.|.:...|||.|:..|:...::.|.||.:. |.
 Worm   461 PPEIGFSAQAFELENVQRVEETDWNMTYLCRKRGDAPGNISWHFDLKSLKKSIEKIEIRMAGIQK 525

Human   576 FQTGTVEWKLRSDTAQVELTGDNSLHSYADFSGAT-------EVI-LEAELSRGDGDVAWQHTQL 632
            |:.|        ....:...||:.:....|.|..|       |:: :.|.||.|:|.:.:|..|:
 Worm   526 FEKG--------KAMAIACLGDSCMRLPIDCSALTIEDPKNAEILKITATLSGGEGAIGFQQAQI 582

Human   633 FRQSL 637
            ||..|
 Worm   583 FRTEL 587

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NGLY1NP_060767.2 PUB_PNGase 19..109 CDD:198417
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 112..163 8/23 (35%)
Transglut_core 275..354 CDD:376628 46/78 (59%)
Rad4 <338..>392 CDD:427539 31/53 (58%)
PAW 457..651 CDD:461409 57/194 (29%)
png-1NP_492913.1 TRX_family 20..103 CDD:239245 3/9 (33%)
Transglut_core 217..296 CDD:376628 46/78 (59%)
PAW 407..604 CDD:471983 57/194 (29%)
Blue background indicates that the domain is not in the aligned region.

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