Protein Alignment NGLY1 and ngly1

DIOPT Version :10

• Sequence 1: NP_060767.2
• Gene: NGLY1 / 55768
• HGNCID: 17646
• Length: 654
• Species: Homo sapiens
• Sequence 2: XP_002932449.1
• Gene: ngly1 / 100488447
• XenbaseID: XB-GENE-963941
• Length: 635
• Species: Xenopus tropicalis
• Alignment Length: 651
• Identity: 418/651 - (64%)
• Similarity: 508/651 - (78%)
• Gaps: 31/651 - (4%)

Human    14 SPAVAELCQNTPETFLEASKLLLTYADNILRNPNDEKYRSIRIGNTAFSTRLLPVRGAVECLFEM 78
            ||||||||||..:.||:||:|||||||||||:||:|||||||||||||||||||||||:||||||
 Frog     6 SPAVAELCQNERQEFLDASQLLLTYADNILRSPNEEKYRSIRIGNTAFSTRLLPVRGAIECLFEM 70

Human    79 GFEEGETHLIFPKKASVEQLQKIRDLIAIERSSRLDGSNKSHKVKSSQQPAASTQLPTTPSSNPS 143
            |||||||||:|||.||||:|:|:||.||.||:.|:.|:|.:.:...|..|.:|    .:|..||.
 Frog    71 GFEEGETHLVFPKMASVEKLRKVRDHIATERNKRMSGANSTPQATPSTPPMSS----RSPVPNPV 131

Human   144 GLNQHTRNRQGQSSDPPS---------ASTVAADSAILEVLQSNIQHVLVYENPALQEKALACIP 199
                           |||         :|.:|::...|:.||||.||||:||...||::||..||
 Frog   132 ---------------PPSIPLQATEDISSFLASEVRYLKTLQSNSQHVLIYEQSELQQRALQEIP 181

Human   200 VQELKRKSQEKLSRARKLDKGINISDEDFLLLELLHWFKEEFFHWVNNVLCSKCGGQTRSRDRSL 264
            |.:||.::|:||:..:.:|....::.|||||||||.|||::||.|||::.|..|||:|:.|| :|
 Frog   182 VLDLKTRAQQKLTEVKSIDSDTGVNIEDFLLLELLRWFKQDFFQWVNSLPCCLCGGETQGRD-AL 245

Human   265 LPSDDELKWGAKEVEDHYCDACQFSNRFPRYNNPEKLLETRCGRCGEWANCFTLCCRAVGFEARY 329
            .||.::|:|||..||:|||:.|:.||||||||:||||||||.||||||||||||||||:||||||
 Frog   246 SPSAEDLRWGANRVENHYCEKCKHSNRFPRYNHPEKLLETRRGRCGEWANCFTLCCRALGFEARY 310

Human   330 VWDYTDHVWTEVYSPSQQRWLHCDACEDVCDKPLLYEIGWGKKLSYVIAFSKDEVVDVTWRYSCK 394
            |||.||||||||||.||.||||||.||:.||||||||:||||||||:|.||||||||||||||||
 Frog   311 VWDSTDHVWTEVYSTSQNRWLHCDPCENACDKPLLYEVGWGKKLSYIIGFSKDEVVDVTWRYSCK 375

Human   395 HEEVIARRTKVKEALLRDTINGLNKQRQLFLSENRRKELLQRIIVELVEFISPKTPKPGELGGRI 459
            ||:|||||.:|:|:.||:||.||||.||:.|.|||::|||.|:|||||||:|||||||||||||:
 Frog   376 HEDVIARRKEVRESWLRETITGLNKMRQVSLPENRKQELLGRLIVELVEFMSPKTPKPGELGGRV 440

Human   460 SGSVAWRVARGEMGLQ-RKETLFIPCENEKISKQLHLCYNIVKDRYVRVSNNNQTISGWENGVWK 523
            |||:|||:||||..|| .|..:|||.|.|||.|..||.||:|:|.|.||||||:.|:||||||||
 Frog   441 SGSLAWRMARGETSLQSNKSVVFIPSEREKIGKLFHLRYNVVEDAYTRVSNNNEVITGWENGVWK 505

Human   524 MESIFRKVETDWHMVYLARKEGSSFAYISWKFECGSVGLKVDSISIRTSSQTFQTGTVEWKLRSD 588
            .||:.||||.||.||||||.||||.|.||||.||.||||:::|:|:|||.|||.:|.::|||.|.
 Frog   506 AESMCRKVENDWKMVYLARTEGSSSAAISWKIECASVGLQIESLSVRTSGQTFHSGKIKWKLTSP 570

Human   589 TAQVELTGDNSLHSYADFSGATEVILEAELSRGDGDVAWQHTQLFRQSLNDHEENCLEIIIKFSD 653
            ..:||:..|.|||||.:|..::||.|:|||..|||:.|||||||||:|| |.::|.|||||...|
 Frog   571 EVEVEVNSDTSLHSYPEFLNSSEVELKAELCDGDGNTAWQHTQLFRESL-DCKQNSLEIIIMLKD 634

Human   654 L 654
            :
 Frog   635 V 635

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NGLY1	NP_060767.2	PUB_PNGase	19..109	CDD:198417	73/89 (82%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	112..163		12/59 (20%)
		Transglut_core	275..354	CDD:376628	65/78 (83%)
		Rad4	<338..>392	CDD:427539	45/53 (85%)
		PAW	457..651	CDD:461409	123/194 (63%)
ngly1	XP_002932449.1	PUB_PNGase	9..101	CDD:198417	75/91 (82%)
		Transglut_core	256..335	CDD:376628	65/78 (83%)
		Rad4	<319..403	CDD:427539	66/83 (80%)
		PAW	438..632	CDD:461409	123/194 (63%)