Protein Alignment EXOC1 and Sec3

DIOPT Version :10

• Sequence 1: XP_005265804.1
• Gene: EXOC1 / 55763
• HGNCID: 30380
• Length: 912
• Species: Homo sapiens
• Sequence 2: NP_648976.2
• Gene: Sec3 / 39940
• FlyBaseID: FBgn0266669
• Length: 889
• Species: Drosophila melanogaster
• Alignment Length: 960
• Identity: 380/960 - (39%)
• Similarity: 557/960 - (58%)
• Gaps: 125/960 - (13%)

Human     1 MTAIKHALQRDIFTPNDERLLSIVNVCKAGKKKKNCFLCATVTTERPVQVK---VVKVKKSDKGD 62
            |..|||.||:::|..:.|||||:|.|.|. |.||.|:|| .|||..||.|.   ::|..:..:|:
  Fly     7 MANIKHTLQKELFLASGERLLSVVTVVKK-KDKKPCYLC-VVTTAPPVPVVTLCLIKQSEQREGE 69

Human    63 FYKRQIAWALRDLAVVDAKDAIKENPEFDLHFEKIYKWVASSTAEKNAFISCIWKLNQRYLR-KK 126
             |||:.:|.|.::..||.::...|..||||..||:|||.|.:..|:..|::.:.:..|:.:| ::
  Fly    70 -YKRKRSWQLDEIKWVDGRNEQFETHEFDLQLEKLYKWYALNPHERQNFLAVLNRQIQKSVRGQR 133

Human   127 IDFVNVSSQLLEESVPSGENQSVTGG--------------DEEVVDEYQELNAREEQDIEIMMEG 177
            .:|.||.:..|.|..|    :.|..|              :||...|:..|..:|..::..:...
  Fly   134 AEFRNVPAAWLSEKSP----EKVALGRAVQKTQHMDDEEDEEEEAQEFTALTDKEANELGKLFSE 194

Human   178 CEYAISNAEAFAEKLSRELQVLDGANIQSIMASEKQVNILMKLLDEALKEVDQIELKLSSYEEML 242
            |::||.:||.|.|:|||||..|||||:||::|||::|..:|:.:|.|:.|.|:.|.:|.|||::|
  Fly   195 CDFAIKDAEQFIEQLSRELHDLDGANMQSVLASEQKVLKMMEHIDNAISEADKFENRLDSYEDIL 259

Human   243 QSVKEQMDQISESNHLIHLSNTNNVKLLSEIEFLVNHMDLAKGHIKALQEGDLASSRGIEACTNA 307
            ..|||.|::|...|.:|.::|.||:||:.|:..:::.:||.....:||.|.||.::.|.:|...|
  Fly   260 GHVKETMEKIGGKNAMIEIANNNNIKLMKELNKVISQLDLPHSQQQALDEPDLKTANGRKAAIAA 324

Human   308 ADALLQCMNVALRPGHDLLLAVKQQQQRFSDLRELFARRLASHLNNVFVQQFTQALLQLYNRSYF 372
            |..|.|.||..:.|....|.||:.|::||...::.|:..::..:||:|:        .|.|....
  Fly   325 AQCLQQAMNSDIDPALLRLEAVQDQRKRFEKWKQKFSATVSRFMNNLFI--------HLGNEIGD 381

Human   373 LSVPGHDQSSTLAQHSVELTLPNHHPFHRDLLRYAKLMEWLKSTDYGKYEGLTKNYMDYLSRLYE 437
            :.|.           |.|||||||...||:|..|.:||.|.|:.|...|:||.:.|...||::|:
  Fly   382 MQVT-----------STELTLPNHSNVHRELTPYTELMHWTKAMDRKTYDGLMRVYTASLSKIYD 435

Human   438 REIKDFFEVAKIKMTGTTKESKKFATLPRKESAVKQETESLHGSSGKLTGSTSSLNKLSVQSSGN 502
            |::::||.:|||                       |.||.|..|...|..||||
  Fly   436 RDVRNFFNLAKI-----------------------QVTEKLRNSREDLDMSTSS----------- 466

Human   503 RRSQSSSLLDMGNMSAS------DLDVADRTKFDKIFEQVLSELEPLCLAEQDFISKFFKLQQHQ 561
             |..:.|.:..|.:..:      .::.|||.:||.:.|:||:||||:.|.||.|...||  |...
  Fly   467 -RKSAVSTIPYGTLGINRDQWGPGVETADRMRFDALLEKVLAELEPIALQEQLFCINFF--QMDV 528

Human   562 SMPGT--------MAEAEDLDGGTLS----------------RQHNCGTPLPVSSEKDMIRQMMI 602
            ..|.|        |.:|.|:....:|                ||.|           :.:|::|:
  Fly   529 ISPTTKNTQTTLEMEKAVDMTQSIISGAVSPSGDGVPQKRIDRQIN-----------EDVRKLMM 582

Human   603 KIFRCIEPELNNLIALGDKIDSFNSLYMLVKMSHHVWTAQNVDPASFLSTTLGNVLVTVKRNFDK 667
            .:|.|:||||.:.|...:::|||.|||:.|:::.||.:||  |..||||.|..:.||.|||:||:
  Fly   583 GLFGCLEPELVSFIQSFERVDSFYSLYVFVRLTQHVMSAQ--DTHSFLSMTFASALVQVKRSFDR 645

Human   668 CISNQIRQMEEVKISKKSKVGILPFVAEFEEFAGLAESIFKNAERRGDLDKAYTKLIRGVFVNVE 732
            .:.||:..:.|.|:.|:|| .|||:|..||.||..||.||:.::||.|::|.|.:|:..:|..::
  Fly   646 FMQNQLLSIREAKLHKRSK-AILPYVENFENFAQTAEGIFRKSDRRTDMEKWYLQLVNAIFEGIQ 709

Human   733 KVANESQKTPRDVVMMENFHHIFATLSRLKISCLEAEKKEAKQKYTDHLQSYVIYSLGQPLEKLN 797
            ..:.|..|||..||.|||:||::|.|::||:..|:|.|||||:.|.|.|::||....|:||||||
  Fly   710 LHSQEHPKTPVQVVRMENYHHMYALLAQLKVPGLDALKKEAKKCYNDALKAYVTQYFGRPLEKLN 774

Human   798 HFFEGVEARVAQGIREEEVSYQLAFNKQELRKVIKEYPGKEVKKGLDNLYKKVDKHLCEEENLLQ 862
            .|||||:.:||||::|.|:|||:||:||||||||.:||.:||||||:||||||:|||.|||||||
  Fly   775 QFFEGVQLKVAQGVKETEISYQMAFSKQELRKVIAQYPAREVKKGLENLYKKVEKHLSEEENLLQ 839

Human   863 VVWHSMQDEFIRQYKHFEGLIARCYPGSGVTMEFTIQDILDYCSSIAQSH 912
            ||||:||:|||.||.:.|..|.:||.|:.:.:||.|||||.:.|.||:||
  Fly   840 VVWHAMQEEFIAQYNYLEERIQKCYAGAMINLEFNIQDILAFFSDIARSH 889

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EXOC1	XP_005265804.1	PH-EXOC1	3..120	CDD:270202	48/119 (40%)
		Sec3_C	184..889	CDD:401638	300/734 (41%)
Sec3	NP_648976.2	PH-EXOC1	9..126	CDD:270202	48/119 (40%)
		Sec3_C	200..866	CDD:401638	300/735 (41%)