DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PRKAR2A and Pka-R2

DIOPT Version :9

Sequence 1:	NP_001308911.1	Gene:	PRKAR2A / 5576	HGNCID:	9391	Length:	404	Species:	Homo sapiens
Sequence 2:	NP_523671.1	Gene:	Pka-R2 / 36041	FlyBaseID:	FBgn0022382	Length:	377	Species:	Drosophila melanogaster

Alignment Length:	393	Identity:	193/393 - (49%)
Similarity:	260/393 - (66%)	Gaps:	33/393 - (8%)

- Green bases have known domain annotations that are detailed below.

Human     4 IQIPPGLTELLQGYTVEVLRQQPPDLVEFAVEYFTRLREARAPASVLPAATPRQSLGHPPPEPGP 68
            ||:|..|.|:|..:::..|.:||||::::||||||:|:..|...|....:|..|.
  Fly     9 IQVPEELKEVLLQFSISFLVEQPPDVIDYAVEYFTKLQSERPSVSHTDQSTDDQL---------- 63

Human    69 DRVADAKGDSESEEDEDLEVPVPSRFNRRVSVCAETYNPDEEEEDTDPRVIHPKTDEQRCRLQEA 133
                     |.:.:|.|.|.||.:. :||.||.||.|:|:.:::|.....:.|||||||.||.|:
  Fly    64 ---------SVNSQDADAEPPVMAS-SRRKSVFAEAYDPEADDDDDGATAVFPKTDEQRARLVES 118

Human   134 CKDILLFKNLDQEQLSQVLDAMFERIVKADEHVIDQGDDGDNFYVIERGTYDILVTKDNQTRSVG 198
            .|::|||::|::||::|||||||||.|:..:.:|.||||||||||||.|.|.:.:    ..:.:.
  Fly   119 VKNVLLFRSLEKEQMNQVLDAMFERKVQPGDFIIRQGDDGDNFYVIESGVYKVYI----NDKHIN 179

Human   199 QYDNRGSFGELALMYNTPRAATIVATSEGSLWGLDRVTFRRIIVKNNAKKRKMFESFIESVPLLK 263
            .|::.|.||||||:||.|||||:.|.:.|.||.:||.|||||::|:..:||||:|..:.|||:||
  Fly   180 TYNHTGLFGELALLYNMPRAATVQAETSGLLWAMDRQTFRRILLKSAFRKRKMYEELLNSVPMLK 244

Human   264 SLEVSERMKIVDVIGEKIYKDGERIITQGEKADSFYIIESGEVSILIRSRTKSNKDGGNQEVEIA 328
            :|:..|||.:.|.:..|.|.:|||||.||:.||..|.||.|.||:        ..|..:.||||:
  Fly   245 ALQNYERMNLADALVSKSYDNGERIIKQGDAADGMYFIEEGTVSV--------RMDQDDAEVEIS 301

Human   329 RCHKGQYFGELALVTNKPRAASAYAVGD-VKCLVMDVQAFERLLGPCMDIMKRNISHYEEQLVKM 392
            :..||||||||||||::|||||.||.|. ||...:||:|||||||||||||||||..||.||||:
  Fly   302 QLGKGQYFGELALVTHRPRAASVYATGGVVKLAFLDVKAFERLLGPCMDIMKRNIDDYESQLVKI 366

Human   393 FGS 395
            |||
  Fly   367 FGS 369

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PRKAR2A	NP_001308911.1	Dimerization and phosphorylation	2..138		48/133 (36%)
		DD_RIIalpha_PKA	4..44	CDD:213050	18/39 (46%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	47..90		7/42 (17%)
		Crp	135..>244	CDD:223736	58/108 (54%)
		CAP_ED	139..251	CDD:237999	59/111 (53%)
		Crp	255..>371	CDD:223736	60/116 (52%)
		CAP_ED	261..382	CDD:237999	68/121 (56%)
Pka-R2	NP_523671.1	DD_RII_PKA	11..49	CDD:213046	16/37 (43%)
		CAP_ED	124..233	CDD:237999	60/112 (54%)
		CAP_ED	242..356	CDD:237999	68/121 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165160283
Domainoid	1	1.000	93	1.000	Domainoid score	I7549
eggNOG	1	0.900	-	-		E1_COG0664
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3064
Inparanoid	1	1.050	361	1.000	Inparanoid score	I2202
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54324
OrthoDB	1	1.010	-	-		D1047290at2759
OrthoFinder	1	1.000	-	-		FOG0000531
OrthoInspector	1	1.000	-	-		otm41080
orthoMCL	1	0.900	-	-		OOG6_100449
Panther	1	1.100	-	-	O	PTHR11635
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2591
SonicParanoid	1	1.000	-	-		X421
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800