Protein Alignment RCOR3 and CoRest

DIOPT Version :10

• Sequence 1: NP_001336998.1
• Gene: RCOR3 / 55758
• HGNCID: 25594
• Length: 585
• Species: Homo sapiens
• Sequence 2: NP_001188671.1
• Gene: CoRest / 32941
• FlyBaseID: FBgn0261573
• Length: 824
• Species: Drosophila melanogaster
• Alignment Length: 689
• Identity: 200/689 - (29%)
• Similarity: 289/689 - (41%)
• Gaps: 240/689 - (34%)

Human     3 GMMEKGPELLGKNRSANGSAKSPAGGGGSGASS-TNGGLHYSE------PESGC--SSDD----- 53
            |...:||   ..|....|...:.|...|||.:| .:|..:.:|      |.:|.  ||||
  Fly    15 GRRSRGP---SPNTHTTGGVTNSASLVGSGNNSGHSGNANANEKTTTAVPGAGTPESSDDDNSTK 76

Human    54 ----------EHDVGMRVGAEYQARIPEFDPVETRSCYVSQAGLKLRGSSHPPSLASQSAGIIGA 108
                      |::..:|||.:|||..|...|...|.                |...::.|
  Fly    77 RNGKSKAKQSEYEEKIRVGRDYQAVCPPLVPEAERR----------------PEQMNERA----- 120

Human   109 TKYTDKDNGGMLVWSPYHSIPDAKLDEYIAIAKEKHGYNVEQALGMLFWHKHNIEKSLADLPNFT 173
                      :|||||...|||.||:|||::||||:|||.||||||||||||::|:::.||.|||
  Fly   121 ----------LLVWSPTKEIPDLKLEEYISVAKEKYGYNGEQALGMLFWHKHDLERAVMDLANFT 175

Human   174 PFPDEWTVEDKVLFEQAFSFHGKSFHRIQQMLPDKTIASLVKYYYSWKKTRSRTSLMDRQARKL- 237
            |||||||:||||||||||.|||||||||:||||||:|||||||||||||||.|:|.||||.:.:
  Fly   176 PFPDEWTIEDKVLFEQAFQFHGKSFHRIRQMLPDKSIASLVKYYYSWKKTRHRSSAMDRQEKAIK 240

Human   238 ------------ANRHNQGDSDD-------------DVEET-------------------HPMDG 258
                        ...:.:.|:||             |...|                   :.::.
  Fly   241 AVVKDGSENGSEVGSNEESDNDDKKGHGTNSTINTIDATTTSTNNSTTNSNTTTPANIIANTINS 305

Human   259 NDSDYDPKKEAKKEGNTEQPVQ----------TS---------KIGLGRREYQSLQ--------- 295
            |.|..:.........|.|:.:|          ||         .:..|..:.:.:.
  Fly   306 NHSSSNSGGGGNINNNGEENIQAVGGSNTISNTSNNDMDAEQLSLFAGNAQIEEMMALGLAADRA 370

Human   296 ----------------------------------------------------HRH---------- 298
                                                                |.|
  Fly   371 IGANGGNNNNNGEMGGDPGLMRRMVVGGFCKICNVVCHVLHDSPLGRMCKSCHTHWRRTGNRRPI 435

Human   299 ------------H-----SQRSKCRPPKGMYLTQEDVVAVSCSPNAANTILRQLDMELISLKRQV 346
                        |     :.|||.:||||||:..:|:.|::...| .:..|.:.:.:|.:|..::
  Fly   436 SGPEGNAPRRSTHNCAATADRSKRKPPKGMYINHDDLTALASCGN-PSLYLAERERKLTALMAEI 499

Human   347 QNAKQVNSALKQKMEG-GIEEF--KPPESN-----QKINARWTTEEQLLAVQGVRKYGKDFQAIA 403
            |..:||...|.::.|. .:::.  ||..:|     .:|:|||..:|..:|:..:|:|||:|..||
  Fly   500 QKNRQVMEQLDKECETINVDDVLSKPAAANTESAQPRISARWLPDEIQVALLAIREYGKNFPTIA 564

Human   404 DVIGNKTVGQVKNFFVNYRRRFNLEEVLQEWEA----EQGTQ-------------ASNGDASTLG 451
            .|:..||...|:.|::|.|||:||:::::|:||    |.|.:             |:...|.:..
  Fly   565 KVVATKTEAHVRTFYLNNRRRYNLDQIVKEYEAGKSEESGAEEQTEPAVDAAAAGAATASAPSAA 629

Human   452 EETKSASNVPSGKSTDEEE----EAQTPQAPRTLGPSPP 486
            :.|.:||.....|.:.|..    |......|:...|..|
  Fly   630 DSTSAASATADRKQSTENSNNGVETMQESLPKKEDPKKP 668

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RCOR3	NP_001336998.1	ELM2	59..142	CDD:460214	25/82 (30%)
		SANT	178..222	CDD:473887	39/43 (91%)
		Myb_DNA-binding	379..422	CDD:459731	17/42 (40%)
CoRest	NP_001188671.1	ELM2	92..144	CDD:460214	25/82 (30%)
		SANT	180..224	CDD:473887	39/43 (91%)
		Myb_DNA-binding	540..583	CDD:459731	17/42 (40%)