Protein Alignment UGGT2 and Uggt

DIOPT Version :10

• Sequence 1: XP_011519396.1
• Gene: UGGT2 / 55757
• HGNCID: 15664
• Length: 1590
• Species: Homo sapiens
• Sequence 2: NP_524151.2
• Gene: Uggt / 40055
• FlyBaseID: FBgn0014075
• Length: 1548
• Species: Drosophila melanogaster
• Alignment Length: 1573
• Identity: 628/1573 - (39%)
• Similarity: 923/1573 - (58%)
• Gaps: 109/1573 - (6%)

Human    26 SGTVAASKSVTAHLAAKWPETPLLLEASEFMAEESNEKFWQFLETVQEL-AIYKQTESDYSYYNL 89
            ||..:.|..:|..:.|||.:|||.||.:|::|:|....||.::..|.:| .:..:.:::...||.
  Fly    21 SGESSQSYPITTLINAKWTQTPLYLEIAEYLADEQAGLFWDYVSGVTKLDTVLNEYDTESQQYNA 85

Human    90 ILKKAGQFLDNLHINLLKFAFSIRAYSPAIQMFQQIAADEPPPDGCNAFVV--IHKKHTCKINEI 152
            .|:.....:.:..:.||:...|:.:.:|.||...|:|.:......|.:|..  :..:..|..||:
  Fly    86 ALELVKSHVSSPQLPLLRLVVSMHSLTPRIQTHFQLAEELRSSGSCQSFTFAQVGSELACSFNEL 150

Human   153 KKLLKKAASRTR------PYLFKGDHKFPTNKENLPVVILYAEMGTRTFSAFHKVLSEKAQNEEI 211
            :|.|:...::..      .|.|  ||.||.::.|...|:||.::|:..|..:||:|.::|....|
  Fly   151 QKKLEVPLAKDSLDASVVTYSF--DHIFPGSENNTRTVVLYGDLGSSQFRTYHKLLEKEANAGRI 213

Human   212 LYVLRHYIQKPSSRKMYLSGYGVELAIKSTEYKALDDTQVKTVTNTTVEDETETNEVQGFLFGKL 276
            .|:|||.:.|...|.:.||||||||.:||||||:.||.......:|:.||....::||||.|..|
  Fly   214 RYILRHQLAKKDKRPVRLSGYGVELHLKSTEYKSQDDAPKPEAGSTSDEDLANESDVQGFDFKVL 278

Human   277 KEIYSDLRDNLTAFQKYLIESNKQMMPLKVWELQDLSFQAASQIMSAPVYDSIKLMKDISQNFPI 341
            |:.:..|:..|...::.|::.|.::..||.||.|||..|||:.|......:::::::..:.|||:
  Fly   279 KQKHPTLKRALDQLRQRLLQGNDEIAQLKAWEFQDLGLQAAAAIAEIQGDETLQILQYTAHNFPM 343

Human   342 KARSLTRIAVNQHMREEIKENQKDLQVRFKIQPGDARLFINGLRVDMDVYDAFSILDMLKLEGKM 406
            .||:|....|...:|.|:|.|.:.......:.|.|..||||||..|.|..|.:|:::.|:.|.::
  Fly   344 LARTLLAHKVTDGLRAEVKHNTEAFGRSLNVAPPDGALFINGLFFDADTMDLYSLIETLRSEMRV 408

Human   407 MNGLRNLGINGEDMSKFLKLN-SHIWEYTYVLDIRHSSIMWINDLENDDLYITWPTSCQKLLKPV 470
            :..|.:..:.|...|..|.|: :...:..:.:|||.:::.|:||:|||..|..||:|...||:|.
  Fly   409 LESLHSNNVRGSLASSLLALDLTASSKKEFAIDIRDTAVQWVNDIENDVQYRRWPSSVMDLLRPT 473

Human   471 FPGSVPSIRRNFHNLVLFIDPAQEYTLDFIKLADVFYSHEVPLRIGFVFILNTDDEVDGANDAG- 534
            |||.:.:||:|..||||.:|..|......|||::.|..|:.|:|:|.||         .|.||.
  Fly   474 FPGMLRNIRKNVFNLVLVVDALQPTARSVIKLSESFVIHQAPIRLGLVF---------DARDANE 529

Human   535 ------VALWRAFNYIAEEFDISEAFISIVHMYQKVKKDQNILTVDNVKSVLQ--NTFPHANIWD 591
                  ||:..|:||::::.|...|...:..:|..|.:.:.:...|.||.:.:  .:...|...:
  Fly   530 DNLADYVAITCAYNYVSQKKDARAALSFLTDIYAAVGETKVVTKKDIVKQLTKEFTSLSFAKAEE 594

Human   592 ILGIHSKYDEERKAGASFYKMTGLGP--LPQALYNGEPFKHEEMNI-KELKMAVLQRMMDASVYL 653
            .|...|.||..|:..|.|.:..|.|.  .||||.||.|.....:.. .:.:.|:...:|..:..|
  Fly   595 FLEEDSTYDYGRELAAEFIQRLGFGDKGQPQALLNGVPMPSNVVTADSDFEEAIFTEIMTHTSNL 659

Human   654 QREVFLGTLNDRTNAIDFLMDRNNVVPRINTLIL-RTNQQYLNLISTSVTADVEDFSTFFFLDSQ 717
            |:.|:.|.|.|...|||:||::.:|:||:|..|| :.:.:||: |:.....::.:......|.::
  Fly   660 QKAVYKGELTDNDVAIDYLMNQPHVMPRLNQRILSQEDVKYLD-INGVAYKNLGNVGVLNRLSNR 723

Human   718 DKSAVIAKNMYYL--TQDDESI----ISAVTLWIIADFDKPSGRKLLFNALKHMKTSVHSRLGII 776
            |.:|.:..|:.|.  .:..|.|    :..:|:|:.||.:...||.||.:||.::::....|:..|
  Fly   724 DMTATLMDNLKYFGGKKSTELIGRASLQFLTIWVFADLETDQGRDLLTHALDYVQSGESVRVAFI 788

Human   777 YNPTSKINEENTAISRGILAAFL----TQKNMFLRSFLGQLAKEEIATAIYSGDKIKTFLIEGMD 837
            .|..|........::|.:.||..    ||....:..:| :..||:|        :|.|.|.:.:.
  Fly   789 PNTESSSASSRRNLNRLVWAAMQSLPPTQATEQVLKWL-KKPKEKI--------EIPTQLEDILG 844

Human   838 KNAFEKKYNTVGVNIFRTHQLFCQDVLKLRPGEMGIVSNGRFLGPL--DEDFYAEDFYLLEKITF 900
            ......|...|          :.|.||.|...:..::.|||..|||  ||.|.:.||.||.:.:.
  Fly   845 STELHLKMLRV----------YSQRVLGLNKSQRLVIGNGRLYGPLSSDESFDSADFALLARFSS 899

Human   901 SNLGEKIKGIVEN--MGINANNMSDFIMKVDALMSSVPKRA-SRYDV-TFLRENHSVIKTNP-QE 960
            ....:|::.:::.  ..:|....||.::|:.|  |.:|::. :|:.: |.|:.:|||:|..| ||
  Fly   900 LQYSDKVRQVLKESAQDVNEEFNSDTLLKLYA--SLLPRQTKTRFKLPTDLKTDHSVVKLPPKQE 962

Human   961 NDMFFNVIAIVDPLTREAQKMAQLLVVLGKIINMKIKLFMNCRGRLSEAPLERITVIHYEPFLLM 1025
            |...|:|.|::||.:|.|||:..:|::|.:::|.::.|::....:.|:.|::
  Fly   963 NLPHFDVAAVLDPASRAAQKLTPILILLRQVLNCQLNLYLIPVPQHSDMPVK------------- 1014

Human  1026 GIFSSPSCVIGQKTGFYRFVLEPELMSGANDVSSLGPVAKFLDIPESPLLILNMITPEGWLVETV 1090
                          .|||:|:|||:...||...|.||:|||..:|.:|||...:..||.||||.|
  Fly  1015 --------------NFYRYVVEPEVQFEANGGRSDGPLAKFSGLPANPLLTQQLQVPENWLVEAV 1065

Human  1091 HSNCDLDNIHLKDTEKTVTAEYELEYLLLEGQCFDKVTEQPPRGLQFTLGTKNKPAVVDTIVMAH 1155
            .:..|||||.|.|....|.:|::||||||||.|||..:..||||||..|||:::|.:|||||||:
  Fly  1066 RAVYDLDNIKLTDIGGPVHSEFDLEYLLLEGHCFDAASGAPPRGLQLVLGTQSQPTLVDTIVMAN 1130

Human  1156 HGYFQLKANPGAWILRLHQGKSEDIYQIVGHEGTDS--QADLEDIIVVLNSFKSKILKVKVKKET 1218
            .||||||||||||.|||.:|||.|||.|...|||::  .|...::.|::.|.:|.::|::|.|:.
  Fly  1131 LGYFQLKANPGAWSLRLREGKSADIYAISHIEGTNTHHSAGSSEVQVLITSLRSHVVKLRVSKKP 1195

Human  1219 DKIKEDILTDEDEKT--KGLWDSI-KSFTVSLHKENKKEKD--VLNIFSVASGHLYERFLRIMML 1278
            ...:.::|:|::|:.  .|:|:|| .||......:...::|  .:|||||||||||||.|||||:
  Fly  1196 GMQQAELLSDDNEQAAQSGMWNSIASSFGGGSANQAATDEDTETINIFSVASGHLYERLLRIMMV 1260

Human  1279 SVLRNTKTPVKFWLLKNYLSPTFKEVIPHMAKEYGFRYELVQYRWPRWLRQQTERQRIIWGYKIL 1343
            |:|::||:|||||.|||||||.|.:.:||||.||.|:||||||:|||||.||||:||.|||||||
  Fly  1261 SLLKHTKSPVKFWFLKNYLSPQFTDFLPHMASEYNFQYELVQYKWPRWLHQQTEKQRTIWGYKIL 1325

Human  1344 FLDVLFPLAVDKIIFVDADQIVRHDLKELRDFDLDGAPYGYTPFCDSRREMDGYRFWKTGYWASH 1408
            ||||||||.|.||||||||.|||.|:|||.|.||.||||.||||||||:||:|:||||.|||.||
  Fly  1326 FLDVLFPLNVRKIIFVDADAIVRTDIKELYDMDLGGAPYAYTPFCDSRKEMEGFRFWKQGYWRSH 1390

Human  1409 LLRRKYHISALYVVDLKKFRRIGAGDRLRSQYQALSQDPNSLSNLDQDLPNNMIYQVAIKSLPQD 1473
            |:.|:||||||||||||:||:|.||||||.||||||||||||||||||||||||:||||||||.|
  Fly  1391 LMGRRYHISALYVVDLKRFRKIAAGDRLRGQYQALSQDPNSLSNLDQDLPNNMIHQVAIKSLPDD 1455

Human  1474 WLWCETWCDDESKQRAKTIDLCNNPKTKESKLKAAARIVPEWVEYDAEIRQLLDHLENKKQDTSS 1538
            ||||:|||.|.:.:.||.|||||||:|||:||.||.||||||.:||||::.|:..:|:  .:.|.
  Fly  1456 WLWCQTWCSDSNFKTAKVIDLCNNPQTKEAKLTAAQRIVPEWKDYDAELKTLMSRIED--HENSH 1518

Human  1539 TRSMAASASGEAS 1551
            :|..|...|.:.|
  Fly  1519 SRDSAVDDSVDDS 1531

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
UGGT2	XP_011519396.1	Thioredoxin_12	45..226	CDD:465748	52/189 (28%)
		Thioredoxin_13	296..424	CDD:465749	40/127 (31%)
		Thioredoxin_14	437..686	CDD:465750	87/260 (33%)
		Thioredoxin_15	710..933	CDD:465751	58/236 (25%)
		UDP-g_GGTase	1121..1226	CDD:461910	53/106 (50%)
		Glyco_transf_24	1259..1525	CDD:436473	207/265 (78%)
Uggt	NP_524151.2	Thioredoxin_12	40..227	CDD:465748	52/188 (28%)
		Thioredoxin_13	300..414	CDD:465749	38/113 (34%)
		Thioredoxin_14	440..692	CDD:465750	87/260 (33%)
		Thioredoxin_15	717..934	CDD:465751	59/237 (25%)
		UDP-g_GGTase	1095..1204	CDD:461910	54/108 (50%)
		Glyco_transf_24	1240..1507	CDD:436473	207/266 (78%)