|
Human 14 GTLSGCSGLVPSVPDDLDGINPNAGLGNGLLPNVSEETVSPTRARNM-KDFENQITELKKENFNL 77
|:|..|..|.| |..:..:....:.|...:....|...|.|:: :|:.:.:.:....:.::
Zfish 163 GSLRRCVSLEP-----LCKVGTDRSHRSKLNSRLKAADVPAPRPRSLSRDYLDVVNKKSSLSRSI 222
Human 78 KLRIYFLEE------RMQQEFHGPTEHIYKTNIELKVEVESLKRELQEREQLLIKASKAVESLAE 136
.|:...||. |..:.|.|.| ...||..||..::.: |:|..:.|..:..
Zfish 223 SLQSVALENTDHALIRQTRPFRGST--------PAAVEKTSLVFDILQ----LLKIVQGVRFVPR 275
Human 137 AGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQAELEKAFAGTETEKALRLRLESKLSE 201
.|||.|..:|.... :.|...|.....:: |:|..|.|
Zfish 276 CGGSRIPVLKHPLH-----------------------SHANTHKGGVSWKS------RVERNLRE 311
Human 202 MKKMHEGD---LAMALVLDEKDRLIEELKLSLKSKEALIQCLKEEKSQMACPDENVSSGELRGLC 263
|:.....| |...:::|.::.| .:|..|:::...:..|.:.:.....|
Zfish 312 MEDEFNDDYRPLKREIIVDRQNEL---SRLEQKTRQLTEELNKAKNNGQTLKD------------ 361
Human 264 AAPREEKERETEAAQMEHQKERNSFEERIQALEEDLREKEREIATEKKNSLKRDKAIQGLTMALK 328
|....|||: :||.::|:::|.|::|||||||||||||||||:.||
Zfish 362 ALDEMEKEK--------------------KALSDELQKREIELSTEKKNSLKRDKAIQGLTLFLK 406
Human 329 SKEKKVEELNSEIEKLSAAFAKAREALQKAQTQEFQGSEDYETALSGKEALSAALRSQNLTKSTE 393
.|||::|:|:.::|:...|.|||||||.||:.|::.|:||.::.|..::|..:.|:::..:...|
Zfish 407 EKEKEIEDLSGDLEEKDQALAKAREALHKAKLQKYHGAEDQQSLLLEQQAELSRLQAEAHSSLLE 471
Human 394 NHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGDCTIRDLRNEVE-------------- 444
..||:|.:.....|||.|||.:.:||::||:..::|.|||.||.||:|:::
Zfish 472 AQRLQRVLGSRDSELSLLQQAKLQLEQELEQLQQQKKKGDKTINDLQNQLKKLNGTLADRENALD 536
Human 445 -----------------------------------------------------------KLRNEV 450
|||..:
Zfish 537 QQRLEQQEQIRASEQKMQNAMERLTASLNHKDQQLQDYMNMVRDLEKNRSQEEGDPMLAKLRARL 601
Human 451 NEREKAME-------------------------------NRYKSLLS------------------ 466
.|:|||:| .|..:|||
Zfish 602 KEKEKALEKALDEKFAAVEEKENEIHLLQLSLREKERDVERLNNLLSHNEETINSFDAVIKERDL 666
Human 467 -----------------ESNKKLH----NQEQVIKHLTES------------------------- 485
|:.:.|| .::.:|:||.::
Zfish 667 ELQQLLNSLKNLQRSKDETEENLHRALREKDAIIQHLQQALDNKTKDMEEMANRVLNQSESQGRD 731
Human 486 ----------------------------------------------------------------- 485
Zfish 732 LAEQMSQRLKVTEAMLSEAVKDRERLVTENQTAVENLLATISSKDQLLKESMERHTHTLSDRSAE 796
Human 486 ---------------------------------------TNQKDVLLQKF----NEKD------- 500
.::||.|:.|. .|||
Zfish 797 MLDLRKQLSDTQQQLRNAQRLNAAATQDGHLEIAELRAMLSEKDALINKLLERGQEKDRSILFEM 861
Human 501 ----------------LEVIQQNCYLMAAE----------------------------------- 514
:|::|:......||
Zfish 862 KSGEAPPPQVLELRQTIELLQEKLEEREAELSRRNSEEMLDVDAVTKKSAVLLKRELLQKTDALN 926
Human 515 ---------------------DLELRSEG-----------------LIT---------------- 525
:||.|.|| :||
Zfish 927 AALKRENQLKISLAELQSSLSELEARLEGQTANIESLTSTLNTKEEIITELHHRLSQRGDSRVPL 991
Human 526 -----------EKCSSQQPPGSKTIFSKEKKQ---------SSDYEELIQVLKKEQDIYTHLVKS 570
|...|..|....||...:::| .|:..||.:.|:.||.:|:.|:::
Zfish 992 TRDQASQLGESEYSPSSLPQRETTIIGGDRQQLDVASLSDLRSEQAELNRALRAEQHLYSDLIRA 1056
Human 571 LQESDSINNLQA---ELNKIFALRKQLEQDVLSYQNLRKTLEEQISEIRRRE------------- 619
::|.||:..||. ||..:..||:|||..|.....||..|:.:|...::||
Zfish 1057 VKERDSVERLQVLQLELTAVALLRQQLESGVQMNSELRDQLQTEIHRTKQREGSNPSELQTLRDA 1121
Human 620 -EE------------------------------SFSLYSDQTSYLSICLEENNRFQVEHFSQEEL 653
|| :.|:..|||||:|||:.|....::.|.:.::|
Zfish 1122 LEEAQRWNVSLQARLGQIQNRGGGVGQANDSVDTLSMIGDQTSYMSICVGEGPEEELLHMTVDQL 1186
Human 654 KKKVSDLIQLVKELYTDNQHLKKTIFDLSCMGFQGNGFPDRL---------------ASTEQTEL 703
:.||.:|..:..||......|:|.....:.:|......||.: .|.|...|
Zfish 1187 RLKVLELEAVNAELQKKLVLLEKDTVGNAPIGSHSQKEPDLIDLSTPTKQPQRQQKPTSEEGASL 1251
Human 704 LASK-----EDEDTIKIGEDDEINFLSDQHLQQSNEIMKDLSKGGCKNGYLRHTESKISDCDGAH 763
|||. ||.|. ...|.:.......:|:....::..||...........:|.:||| ||.
Zfish 1252 LASNVKERCEDGDR---SSKDRVKMNQPSQMQKQLSAVQPTSKFPGDESEKAELKSLLSDC-GAE 1312
Human 764 APGCLEEGAFINLLAPLFNEKATL--LL------------------ESRPDL---LKVVRELLLG 805
:...|.| .:|.|.:|.:.| || :|..|| :||:|.....
Zfish 1313 SVSQLRE-----QVAKLRSEASELRGLLKEENATESKESAESSGESDSHGDLHHTVKVLRSEARS 1372
Human 806 Q----LFLTEQ------------------------------------------------------ 812
. .||.||
Zfish 1373 HRKIIRFLKEQLERNSDGVTQLDTKVMVSMAGNVEQLQTQHEESQRHASTLEKKQREGTEMEDKD 1437
Human 813 ------------------------------------------------EVSGEHL---------- 819
||:.:|:
Zfish 1438 ERRRHVRSTKPSKSQKQNMARHAAYVKSRLPVPVRSSRSTGQSSEDLSEVNSDHIQPKRKDHQTG 1502
Human 820 --------DGKTEKTPKQKGEL------------VHFVQTNSFSKPHDELKLSCEAQLV------ 858
|.|......|||.| ....:.::::..:.|.:|..:.:|:
Zfish 1503 AEESDYSTDSKMSSRSSQKGHLELDQVKDARLSPTSGTKQDNYTDDYLESELMAQLELLNQECQE 1567
Human 859 ----------KAGEVPKVGL----KD-----------ASVQTVA--------------TEGDL-L 883
:..|:.::.: || |:..|:| ..||: |
Zfish 1568 KEELISHLKQQVQELDELQVELQKKDKLNREYLEALQAAESTIAYLTACSLDSECGIGQTGDVTL 1632
Human 884 RFKHEATREAWEEKP-INTALSAEHRPENLHGVPGWQAALLSLPGI--TNREAKKSRLPILIKPS 945
:.:....::|.|||. :||.| |..:...::|:.||..: |.|:..:.:....:...
Zfish 1633 QQRCAELQKAIEEKDRVNTQL--------LECLNTAESAIASLQNVDTTTRQMDQGQADPKVLCE 1689
Human 946 RSLGNMYRLPATQEVV------------------TQLQSQILELQGELKEFKTCNKQLHQKLILA 992
|..|.:.::..:|:.: :.|:.|:..||..:.:....|.:|.:||.::
Zfish 1690 RLEGLIIQVKTSQQNIDGTKDLQRLDIETKLGLNSDLRQQVDALQESVLQQCKLNSELQEKLWIS 1754
Human 993 EAVME-------GRPTPDKTLLNAQPPVG--------------------AAYQD-----SPGEQK 1025
||..: |.||..:..|...|..| .|.|. |...|.
Zfish 1755 EAAFKKLSSTKNGAPTDLEGNLTPGPQEGKVQSRQQLTDCLSKCITAAEGAVQSLADVCSKSNQS 1819
Human 1026 GIKTTSSV----W--------RDKEMDSDQQRSYEIDSEICPPDDLASLPSCKENPEDVLSPTSV 1078
.::..||. | .|:||..| |.|.|......| |.:
Zfish 1820 HMENLSSTELQQWLEMLRCALLDREMLED--------------------PDCIEKHHHKTS-TPI 1863
Human 1079 ATYLSSKSQPSAKVSVMGTDQS--------ESINTSNE------------------------TEY 1111
....|||||..:.:....|.|: ..|:|.:. ||.
Zfish 1864 QNSESSKSQQQSNILDSNTHQNLHKNLLMLLQIHTEHAQKMAKLEKDLSRCGQNAGGGDAPGTEN 1928
Human 1112 LKQ--KIHDLETELEGYQNFIFQLQKHSQCSEAIITVLCGTE----------------------G 1152
|:: :|..|:..|:..|....:|::....::::|.|...:. .
Zfish 1929 LERNAQIESLQKALKERQRACQKLEEKLALAQSVIAVHNASNKDKHSDQNKAPPGERDDKGVQVE 1993
Human 1153 AQDGLSKPKNGSDGEEMTFSSLHQVRYVKHVKILGPL--------APEM---------------- 1193
||| |....:|....|:..||......::.|..|.|: :|:|
Zfish 1994 AQD-LGYETSGRSETEVEGSSTDVDGVLRLVPALSPVLSGPQDRFSPDMSTTSSPSYPSSPGLSS 2057
Human 1194 -------IDS---------------RVLENLKQQL-------------------EEQEYKLQKEQ 1217
.|| ||:::|::|| ||:|.|:.|.|
Zfish 2058 PRPSEPHADSNMHIQQLRSQIEGQHRVIQHLQRQLRKKSLSSELLSVTSDLTAGEEEETKMMKAQ 2122
Human 1218 --NLNMQLFSEIHNLQNKFRDLSPPRYDSLVQSQARELSLQRQQIKDGHGICVISRQHMNTMIKA 1280
.||.:|..| .:|....:..||.|.:||||||||||...|:||:...|:.:..|:.:..:..|
Zfish 2123 IAQLNTELERE-RSLNRSSQPGSPSRIESLVQSQARELCELREQIRVSRGLGLEQRKQLLELRGA 2186
Human 1281 FEELLQASDVDYCVAEGFQEQLNQCAELLEKLEKLFLNGKSVGVEMNTQNELM------------ 1333
.|:|||.:|:........:|||::...|||:||::...|.:|..|...::|:|
Zfish 2187 LEDLLQPTDMHSDQGAQLREQLDRSLSLLERLEQVSTGGVAVENEEGAESEMMLSDCDWVFEELQ 2251
Human 1334 ----------------------------------------ERIEEDNL--TYQHLLP-ESPEPSA 1355
|..|:|.| ..||.|. ::|.
Zfish 2252 CLRSQIEGDRDQQQLQMVYLCRQNQNLAISTQHYVDLLSAELQEKDKLIQALQHQLQIQAPR--- 2313
Human 1356 SHALSDYETSEKSFFSRD----------------------------------------------- 1373
.|..||.|.|:: .|.|
Zfish 2314 MHLHSDSEMSDR--LSNDGTSSCQDSPPSLCRHTPGRPHTGPKATNGDAFTDTGLVSGGRASEGG 2376
Human 1374 ------------------------------------------------QKQDNETEK----TSVM 1386
|.||.:.|| ||..
Zfish 2377 VADGAEPRVRILQRENCRLQEQLRSSEELNTTLRSELDLTRSIIKHSPQTQDKQPEKQNTYTSKT 2441
Human 1387 VNSFSQDLLMEHIQEIRTLRKRLEESIKTNEKLRKQLERQ--GSEFVQGSTSIFASGSELHSSLT 1449
:|| |||.||:||||.||:||||:|:|||:||:|||:: .:|....:|:||.:|||..|.::
Zfish 2442 INS---DLLAEHLQEIRALRQRLEETIRTNERLREQLEKKLLEAEKDPAATNIFIAGSEDQSHIS 2503
Human 1450 SEIHFLRKQNQALNAMLIKGSRDKQKENDKLRESLSRKTVSLEHLQREYASVKEENERLQKEGSE 1514
||:|||..||.:|...|.:|:||||||||:|||:|:|:|..||..:.|..::|:|..:||
Zfish 2504 SELHFLLAQNHSLKEQLNQGARDKQKENDRLRETLARRTAKLEMSRNECETLKQERLQLQ----- 2563
Human 1515 KERHNQQLIQEVRCSGQELSRVQEEVKLRQQLLSQNDKLLQSLRVELKAYEKLDEEHRRLREASG 1579
..|.|:|.|...::|.||...:||||:||||:.:|.:...|.: ||
Zfish 2564 ----------------DNLYRLQCENSHQRQQLSDTQQLLQSVRVELQVHEHMKSTHTQ----SG 2608
Human 1580 EGWKGQD---PFRDLHSLLMEIQALRLQLERSIETSSTLQSRLKEQ-LARGAEKAQEGALTLAVQ 1640
||..... ...|:..||.||:.||:||||||:.:|||:.||::| |:|..:
Zfish 2609 EGRSSSSAGGSAVDMSELLAEIRQLRVQLERSIQINSTLRQRLEQQLLSRRTD------------ 2661
Human 1641 AVSIPEVPLQPDKHDGDKYPMESDN-SFDLFDSSQAVTPKSVSETPPLSGNDTD-SLSCDSGSSA 1703
|..:.| ::.|..:.:||....:.....:|..:.| ..|.||||:|
Zfish 2662 -------------------PKSTININYLLSKTDEAVKSDVLHLQTDVSSAERDGGSSADSGSNA 2707
Human 1704 TSTPCVSRLVTGHHLWASKNGRHVLGLIEDYEALLKQISQGQRLLAEMDIQTQEAPSSTSQELGT 1768
. ||||.||.|||.:.|||||||||||.||.|||::.:||.|:::.|..:...|..|
Zfish 2708 P-----SRLVPGHRLWADRRGRHVLGLIEDYNALRKQITEAKRLTADLETQIHDCGRSVDQ---- 2763
Human 1769 KGPHPAPLSKFVSSVSTAKLTLEEAYRRLKLLWRVSLPEDGQCPLHCEQIGEMKAEVTKLHKKLF 1833
|......|:|.:..||||.|.||||||||:|.. ..|.:|...:::|:::|..:|.
Zfish 2764 -------LKSVSGGVNTMQQVLEEAARLLKLLWRVSVPSG---DTHSQQDDMLQSEISRLKSRLS 2818
Human 1834 EQEKKLQNTMKLL----QLSKRQEKVIFDQLVVTHKILRKARGNLE 1875
:||:.|...:|.| ||.:..|:||.|||.:||.:|::||||||
Zfish 2819 QQERMLSGAVKRLRSTNQLKEGMERVIIDQLSLTHGVLKRARGNLE 2864
| 
