Protein Alignment CDK5RAP2 and Cdk5rap2

DIOPT Version :10

• Sequence 1: NP_060719.4
• Gene: CDK5RAP2 / 55755
• HGNCID: 18672
• Length: 1893
• Species: Homo sapiens
• Sequence 2: XP_006238335.1
• Gene: Cdk5rap2 / 286919
• RGDID: 708451
• Length: 1903
• Species: Rattus norvegicus
• Alignment Length: 1914
• Identity: 1348/1914 - (70%)
• Similarity: 1545/1914 - (80%)
• Gaps: 32/1914 - (1%)

Human     1 MMDLVLEEDVTVPGTLSGCSGLVPSVPDDLDGINPNAGLGNGLLPNVSEETVSPTRARNMKDFEN 65
            |||..:|||||:||||||||||.|.:|.|||.|:...|||||:||.:|||.||||||||||||||
  Rat     1 MMDSGMEEDVTLPGTLSGCSGLHPVLPSDLDVISDTTGLGNGVLPIMSEEKVSPTRARNMKDFEN 65

Human    66 QITELKKENFNLKLRIYFLEERMQQEFHGPTEHIYKTNIELKVEVESLKRELQEREQLLIKASKA 130
            ||||||||||||||||||||||:||||.||||||||.||||||||||||||||||:|||:|||||
  Rat    66 QITELKKENFNLKLRIYFLEERIQQEFAGPTEHIYKKNIELKVEVESLKRELQERDQLLVKASKA 130

Human   131 VESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQAELEKAFAGTETEKALRLRL 195
            ||||||.||||||||||||||||||||:||||||.|||:||.|||||||||||||||||||||.|
  Rat   131 VESLAEGGGSEIQRVKEDARKKVQQVEELLTKRIHLLEEDVKAAQAELEKAFAGTETEKALRLSL 195

Human   196 ESKLSEMKKMHEGDLAMALVLDEKDRLIEELKLSLKSKEALIQCLKEEKSQMACPDENVSSGELR 260
            |||||.||||.||||.|.|.|:|||||||||||||||||||||||||||||||.|||||||||||
  Rat   196 ESKLSAMKKMQEGDLEMTLALEEKDRLIEELKLSLKSKEALIQCLKEEKSQMASPDENVSSGELR 260

Human   261 GLCAAPREEKERETEAAQMEHQKERNSFEERIQALEEDLREKEREIATEKKNSLKRDKAIQGLTM 325
            ||.|..||||||:.|    |.|||||.||||||||:|||||||||||||||||||||||||||||
  Rat   261 GLSATLREEKERDAE----ERQKERNHFEERIQALQEDLREKEREIATEKKNSLKRDKAIQGLTM 321

Human   326 ALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQTQEFQGSEDYETALSGKEALSAALRSQNLTK 390
            |||||||:||||||.|::|:|...::|||..|.|..||:.||:.|.||:.||||.|.|.|:|:||
  Rat   322 ALKSKEKEVEELNSIIKELTADSTQSREAPLKTQVSEFEESENCEAALAEKEALLAKLHSENVTK 386

Human   391 STENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGDCTIRDLRNEVEKLRNEVNEREK 455
            :||||||.|::||:||||:||::|:.|||:||||||||.::|..||.||||||||||.||.||||
  Rat   387 NTENHRLLRNVKKVTQELNDLKKEKLRLERDLEEAHREGNRGARTIHDLRNEVEKLRKEVCEREK 451

Human   456 AMENRYKSLLSESNKKLHNQEQVIKHLTESTNQKDVLLQKFNEKDLEVIQQNCYLMAAEDLELRS 520
            |:|..||||..||:.|.|:||||:|.||||.:|:|:||||.||||||.||||||||.||:|:..|
  Rat   452 AVEKHYKSLPGESSSKFHSQEQVVKGLTESASQEDLLLQKSNEKDLEAIQQNCYLMTAEELKFGS 516

Human   521 EGLITEKCSSQQPPGSKTIFSKEKKQSSDYEELIQVLKKEQDIYTHLVKSLQESDSINNLQAELN 585
            :||||||| |||.|.||.||||||:| |:||.|...||.||::|.||.|:||::||  .|||||.
  Rat   517 DGLITEKC-SQQSPDSKLIFSKEKQQ-SEYEGLTGDLKTEQNVYAHLAKNLQDTDS--KLQAELK 577

Human   586 KIFALRKQLEQDVLSYQNLRKTLEEQISEIRRREEESFSLYSDQTSYLSICLEENNRFQVEHFSQ 650
            ::.|||||||||||:|:||:..|:||:||||:||||.||.||||||||||||||:::||:|||||
  Rat   578 RVLALRKQLEQDVLAYRNLQTALQEQLSEIRKREEEPFSFYSDQTSYLSICLEEHSQFQLEHFSQ 642

Human   651 EELKKKVSDLIQLVKELYTDNQHLKKTIFDLSCMGFQGNGFPDRLASTEQTELLASKEDEDTIKI 715
            ||:||||.|||||||:|:.|||||||||||:||||.|||   |||.||:|.||:|||.||||:|.
  Rat   643 EEIKKKVIDLIQLVKDLHADNQHLKKTIFDISCMGVQGN---DRLESTKQAELMASKADEDTLKF 704

Human   716 GEDDEINFLSDQHLQQSNEIMKDLSKGGCKNGYLRHTESKISDCDGAHAPGCLE----EGAFINL 776
            ..|||.:|.|||||:||.|||:|.::||.|:||:||.:|.|.|.||||.|...|    |...::|
  Rat   705 KADDENHFQSDQHLEQSREIMEDYAEGGGKDGYVRHMDSNILDHDGAHTPDTSEDHSLEDELLSL 769

Human   777 LAPLFNEKATLLLES--RPDLLKVVRELLLGQLFLTEQEVSGEHLDGKTEKTPKQ-----KGELV 834
            ||..|::|||..|||  ||||||.:..|||.::.|.||...|:|.|.|.||..:|     :.||.
  Rat   770 LATFFSKKATPSLESRNRPDLLKALGALLLERICLAEQGSPGDHSDSKAEKALEQVAVRLRDELG 834

Human   835 HFVQTNSFSKPHDELKLSCEAQLVKAGEVPKVGLKDASVQTVATEGDLLRFKHEATREAWEEKPI 899
            |....|||||.|.|||......|||.|:..||.||..||||:..|.....||.|..||||..||.
  Rat   835 HSCLANSFSKSHSELKSPRGTWLVKTGDEAKVELKSVSVQTMTIEDSTRGFKPERKREAWAGKPE 899

Human   900 NTALSAEHRPENLHGVPGWQAALLSLPGITNREAKKSRLPILIKPSRSLGNMYRLPATQEVVTQL 964
            ....|.|...|.|..:||.||..||.|...:::.:|:.|.|.:|....|.|:|.|||:||||.||
  Rat   900 EAVFSTELESEALGEMPGLQATHLSFPSAIDKDDQKTGLLIQLKTPELLENLYNLPASQEVVAQL 964

Human   965 QSQILELQGELKEFKTCNKQLHQKLILAEAVMEGRPTPDKTLLN---AQPPVGAAYQDSPGEQKG 1026
            |.|:||||.||||:|..||||..|||||||:|||...|:.|.:|   ||..|..|:|..||||:|
  Rat   965 QGQVLELQKELKEYKIRNKQLLDKLILAEAMMEGMAVPNSTPVNVPAAQAVVRTAFQGKPGEQEG 1029

Human  1027 IKTTSSVWRDKEMDSDQQRSYEIDSEICPPDDLASLPSCKENPEDVLSPTSVATYLSSKSQPSAK 1091
            .:||.|..||||:||||..|:|||||||||||||.||:||||.||.|.|.|:||||.||||.|.|
  Rat  1030 HETTHSAGRDKEVDSDQYTSFEIDSEICPPDDLALLPACKENLEDFLGPPSIATYLDSKSQLSVK 1094

Human  1092 VSVMGTDQSESINTSNETEYLKQKIHDLETELEGYQNFIFQLQKHSQCSEAIITVLCGTEGAQDG 1156
            |||:||||||:||..::||.||||||||:||||||:|.|.|||||||||||||||||||||||||
  Rat  1095 VSVVGTDQSENINLPDDTEALKQKIHDLQTELEGYRNIIVQLQKHSQCSEAIITVLCGTEGAQDG 1159

Human  1157 LSKPKNGSDGEEMTFSSLHQVRYVKHVKILGPLAPEMIDSRVLENLKQQLEEQEYKLQKEQNLNM 1221
            |:|||...|.||||||||||||||||:|||.||.||:||.::||:|||||.|||.:|||||:||:
  Rat  1160 LNKPKGHIDEEEMTFSSLHQVRYVKHMKILRPLTPEIIDGKMLESLKQQLVEQEQELQKEQDLNL 1224

Human  1222 QLFSEIHNLQNKFRDLSPPRYDSLVQSQARELSLQRQQIKDGHGICVISRQHMNTMIKAFEELLQ 1286
            :||.||||||||||||||.||||||||||||||||||||||.|.|||:..|||:|||||||||||
  Rat  1225 ELFGEIHNLQNKFRDLSPSRYDSLVQSQARELSLQRQQIKDSHDICVVCHQHMSTMIKAFEELLQ 1289

Human  1287 ASDVDYCVAEGFQEQLNQCAELLEKLEKLFLNGKSVGVEMNTQNELMERI--EEDNLTYQHLLPE 1349
            |||||.||||||:|||.|||.|||:||||||:|||..||.:||.||:.|:  |||||.|||||||
  Rat  1290 ASDVDSCVAEGFREQLTQCAGLLEQLEKLFLHGKSARVEPHTQTELLRRLRTEEDNLPYQHLLPE 1354

Human  1350 SPEPSASHALSDYETSEKSFFSRDQKQDNETEKTSVMVNSFSQDLLMEHIQEIRTLRKRLEESIK 1414
            ||||||||||||.|.|||||.||:.|.|:||||...:.:.|.||||||||||||||||.||||||
  Rat  1355 SPEPSASHALSDDEMSEKSFLSREPKPDSETEKYPTIASRFPQDLLMEHIQEIRTLRKHLEESIK 1419

Human  1415 TNEKLRKQLERQGSEFVQGSTSIFASGSELHSSLTSEIHFLRKQNQALNAMLIKGSRDKQKENDK 1479
            |||||||||||||.|..||||::.|..||||:||||||.||||||:||:.||.|||::|||||:|
  Rat  1420 TNEKLRKQLERQGCETDQGSTNVSAYSSELHNSLTSEIQFLRKQNEALSTMLEKGSKEKQKENEK 1484

Human  1480 LRESLSRKTVSLEHLQREYASVKEENERLQKEGSEKERHNQQLIQEVRCSGQELSRVQEEVKLRQ 1544
            |||||:|||.||||||.|||||:||||||:::.|||||.||||.|||..|.|||||||||.|.||
  Rat  1485 LRESLARKTESLEHLQLEYASVREENERLRRDISEKERQNQQLTQEVCSSLQELSRVQEEAKSRQ 1549

Human  1545 QLLSQNDKLLQSLRVELKAYEKLDEEHRRLR-----EASGEGWKGQDPFRDLHSLLMEIQALRLQ 1604
            |||.|.|:|||||::|||.||||.|||::|:     ||.|.|.||||||.:||.||.|||.||.|
  Rat  1550 QLLLQKDELLQSLQMELKVYEKLAEEHQKLQQESRGEACGGGQKGQDPFSNLHGLLKEIQVLRDQ 1614

Human  1605 LERSIETSSTLQSRLKEQLARGAEKAQEGALTLAVQAVSIPEVPLQPDKHDGDKYPMESDNSFDL 1669
            .||||:|::||:|:|::||::|:::||||||||||||:|:.|..||.||||.:|.|..|||||||
  Rat  1615 AERSIQTNNTLKSKLEKQLSQGSKQAQEGALTLAVQALSVTEWSLQLDKHDVNKCPEASDNSFDL 1679

Human  1670 FDSSQAVTPKSVSETPPLSGNDTDSLSCDSGSSATSTPCVSRLVTGHHLWASKNGRHVLGLIEDY 1734
            |:|:||:.|||.||||.|||.|.|||||||.|||||..|:..||.|.||||||:|.|:|.|||||
  Rat  1680 FESTQAMAPKSASETPVLSGTDVDSLSCDSTSSATSPSCMPCLVAGRHLWASKSGHHMLCLIEDY 1744

Human  1735 EALLKQISQGQRLLAEMDIQTQEAPSSTSQELGTKGPHPAPLSKFVSSVSTAKLTLEEAYRRLKL 1799
            :||.||||.||.|||:||||||||.|.|||:||.|.....|||||:||::||||.||:|.|.|||
  Rat  1745 DALYKQISWGQTLLAKMDIQTQEALSPTSQKLGPKASFSVPLSKFLSSMNTAKLILEKASRLLKL 1809

Human  1800 LWRVSLPEDGQCPLHCEQIGEMKAEVTKLHKKLFEQEKKLQNTMKLLQLSKRQEKVIFDQLVVTH 1864
            .||||:|.:|||.|||:||||||||:|||||||||||||||||.||||.||.|||:||||||:||
  Rat  1810 FWRVSVPTNGQCSLHCDQIGEMKAEITKLHKKLFEQEKKLQNTAKLLQQSKHQEKIIFDQLVITH 1874

Human  1865 KILRKARGNLELRPGGAHPGTCSPSRPGS 1893
            ::||||||||||||..|||||.|||||||
  Rat  1875 QVLRKARGNLELRPRAAHPGTSSPSRPGS 1903

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CDK5RAP2	NP_060719.4	CM1 motif, interacts with the gTuRC. /evidence=ECO:0000269|PubMed:39321809	51..94		40/42 (95%)
		Interaction with NCKAP5L. /evidence=ECO:0000269|PubMed:26485573	58..196		126/137 (92%)
		Cnn_1N	61..129	CDD:462333	62/67 (93%)
		Smc	146..>458	CDD:440809	241/311 (77%)
		Smc	<401..>621	CDD:440809	146/219 (67%)
		Interaction with MAPRE1. /evidence=ECO:0000269|PubMed:19553473	926..1208		192/284 (68%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1015..1071		38/55 (69%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1084..1105		16/20 (80%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1347..1381		26/33 (79%)
		Smc	<1392..>1641	CDD:440809	183/253 (72%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1500..1521		14/20 (70%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1646..1706		42/59 (71%)
		Interaction with PCNT and AKAP9. /evidence=ECO:0000269|PubMed:20466722	1726..1893		126/166 (76%)
		Interaction with CDK5R1. /evidence=ECO:0000250	1726..1768		31/41 (76%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1754..1774		12/19 (63%)
		Required for centrosomal attachment, Golgi localization and CALM1 interaction	1861..1870		5/8 (63%)
Cdk5rap2	XP_006238335.1	Cnn_1N	61..129	CDD:462333	62/67 (93%)
		Smc	146..>455	CDD:440809	241/312 (77%)
		Smc	<1422..>1648	CDD:440809	156/225 (69%)