Protein Alignment PRKAR1B and Pka-R2

DIOPT Version :10

• Sequence 1: NP_002726.1
• Gene: PRKAR1B / 5575
• HGNCID: 9390
• Length: 381
• Species: Homo sapiens
• Sequence 2: NP_523671.1
• Gene: Pka-R2 / 36041
• FlyBaseID: FBgn0022382
• Length: 377
• Species: Drosophila melanogaster
• Alignment Length: 352
• Identity: 139/352 - (39%)
• Similarity: 207/352 - (58%)
• Gaps: 8/352 - (2%)

Human    27 IQQVLKDCIVHLCISKPERPMKFLREHFEKLEKEENRQILARQKSNSQSDSHDEEVSPTPPNPVV 91
            :::||....:...:.:|...:.:..|:|.||:.|........|.::.|...:.::....||   |
  Fly    15 LKEVLLQFSISFLVEQPPDVIDYAVEYFTKLQSERPSVSHTDQSTDDQLSVNSQDADAEPP---V 76

Human    92 KARRRRGGVSAEVYTEE--DAVSYVRKVIPKDYKTMTALAKAISKNVLFAHLDDNERSDIFDAMF 154
            .|..||..|.||.|..|  |.......|.||..:....|.:::...:||..|:..:.:.:.||||
  Fly    77 MASSRRKSVFAEAYDPEADDDDDGATAVFPKTDEQRARLVESVKNVLLFRSLEKEQMNQVLDAMF 141

Human   155 PVTHIAGETVIQQGNEGDNFYVVDQGEVDVYVNGEWVTNISEGGSFGELALIYGTPRAATVKAKT 219
            ......|:.:|:||::||||||::.|...||:|.:.:...:..|.||||||:|..||||||:|:|
  Fly   142 ERKVQPGDFIIRQGDDGDNFYVIESGVYKVYINDKHINTYNHTGLFGELALLYNMPRAATVQAET 206

Human   220 DLKLWGIDRDSYRRILMGSTLRKRKMYEEFLSKVSILESLEKWERLTVADALEPVQFEDGEKIVV 284
            ...||.:||.::||||:.|..||||||||.|:.|.:|::|:.:||:.:||||....:::||:|:.
  Fly   207 SGLLWAMDRQTFRRILLKSAFRKRKMYEELLNSVPMLKALQNYERMNLADALVSKSYDNGERIIK 271

Human   285 QGEPGDDFYIITEGTASVLQRRSPNEEYVEVGRLGPSDYFGEIALLLNRPRAATVVAR-GPLKCV 348
            ||:..|..|.|.|||.||  |...::..||:.:||...||||:||:.:|||||:|.|. |.:|..
  Fly   272 QGDAADGMYFIEEGTVSV--RMDQDDAEVEISQLGKGQYFGELALVTHRPRAASVYATGGVVKLA 334

Human   349 KLDRPRFERVLGPCSEILKRNIQRYNS 375
            .||...|||:||||.:|:||||..|.|
  Fly   335 FLDVKAFERLLGPCMDIMKRNIDDYES 361

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PRKAR1B	NP_002726.1	Dimerization and phosphorylation	2..136		26/110 (24%)
		DD_RIbeta_PKA	11..64	CDD:438523	8/36 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	67..98		7/30 (23%)
		Pseudophosphorylation motif	96..100		2/3 (67%)
		CAP_ED	137..246	CDD:237999	50/108 (46%)
		CAP_ED	255..370	CDD:237999	53/115 (46%)
Pka-R2	NP_523671.1	DD_RII_PKA	11..46	CDD:438520	6/30 (20%)
		CAP_ED	124..233	CDD:237999	50/108 (46%)
		CAP_ED	242..356	CDD:237999	53/115 (46%)