DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CHFR and SAN1

DIOPT Version :9

Sequence 1:	NP_001154816.1	Gene:	CHFR / 55743	HGNCID:	20455	Length:	664	Species:	Homo sapiens
Sequence 2:	NP_010427.3	Gene:	SAN1 / 851721	SGDID:	S000002550	Length:	610	Species:	Saccharomyces cerevisiae

Alignment Length:	455	Identity:	87/455 - (19%)
Similarity:	151/455 - (33%)	Gaps:	118/455 - (25%)

- Green bases have known domain annotations that are detailed below.

Human    68 KSGQVTLEDTSTSGTVINKLKVVKKQTCPL-----QTGDV-IYLVYRKNEPEHNVAYLYESLSEK 126
            :|||.....|:||.............:.||     ||.:: :.:.|....|| .:|:| .::|..
Yeast     3 ESGQEQNRGTNTSPNNAENNNNSNAASGPLNGGAEQTRNITVSIQYSYFTPE-RLAHL-SNISNN 65

Human   127 QGMTQESFEANKENVFHGTKDTSGAGAGRGADP---------RVPPSSP----------ATQVCF 172
            .. .:.:..|:...:.:||..:.|.|.| |..|         .||.|:|          |.|:..
Yeast    66 DN-NENNSAASGSTIANGTGPSFGIGNG-GHQPDGALVLSFRDVPASTPQDRLNSFISVAAQLAM 128

Human   173 EE-----PQPSTSTSDLF---PTASASSTEPSPAGRERSSSCGSGGGGISPKGSGP--SVASDEV 227
            |.     .:|...:.|.|   |....|..                     ||..||  |:..||.
Yeast   129 ERFNRLLNRPKGISKDEFDKLPVLQVSDL---------------------PKAEGPLCSICYDEY 172

Human   228 SSFASALPDRKTASFSSLEPQDQEDLEPVKKKMRGDG-------DLDLNGQL---LVAQP----- 277
            .....:     |.:....:.:::|:.|..||:...:|       |.|.|..:   .|.:|
Yeast   173 EDEVDS-----TKAKRKRDSENEEESEGTKKRKDNEGAPLRTTADNDSNPSITNATVVEPPSIPL 232

Human   278 RRNAQTVHEDVRAAAGKPDKMEETLTCIICQDLLHDCVSLQPCMHTFCAACYSGWMERSSLCPTC 342
            ....:|::::....:.|                 |..:.| ||.|.|...|...|....:.||.|
Yeast   233 TEQQRTLNDEETNPSYK-----------------HSPIKL-PCGHIFGRECIYKWSRLENSCPLC 279

Human   343 RCPVERICKNHILNNLVEAYLIQHPDKSRSEEDVQSMDARNKITQDMLQPKVRRSFSD------E 401
            |            ..:.|:..:|...:..::|...:..|..:|.:.:..|....|.::      |
Yeast   280 R------------QKISESVGVQRAAQQDTDEVAANEAAFERIRRVLYDPTAVNSTNENSSAPSE 332

Human   402 EGSSEDLLELSDVDSESSDISQP--YVVCRQCPEYRRQAAQPPHCPAPEGEPGAPQALGDAPSTS 464
            ..|:..:..:.:..|....:|:.  ::|.:...........||:.....|..|......:.||.|
Yeast   333 NTSNTTVPTIGNASSGEQMLSRTGFFLVPQNGQPLHNPVRLPPNDSDRNGVNGPSSTTQNPPSNS 397

Human 465 464
Yeast 398 397

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CHFR	NP_001154816.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		FHA	16..105	CDD:238017	10/42 (24%)
		FHA	<31..140	CDD:224630	17/77 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	142..267		33/160 (21%)
		RING	303..346	CDD:238093	12/42 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	388..417		4/34 (12%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	439..461		4/21 (19%)
SAN1	NP_010427.3	HRD1	<242..424	CDD:227568	32/186 (17%)
SAN1	NP_010427.3	zf-RING_2	<251..280	CDD:404518	9/29 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5243
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900