Protein Alignment ARFGAP1 and ArfGAP3

DIOPT Version :10

• Sequence 1: XP_011527203.1
• Gene: ARFGAP1 / 55738
• HGNCID: 15852
• Length: 416
• Species: Homo sapiens
• Sequence 2: NP_001097664.2
• Gene: ArfGAP3 / 40487
• FlyBaseID: FBgn0037182
• Length: 553
• Species: Drosophila melanogaster
• Alignment Length: 553
• Identity: 135/553 - (24%)
• Similarity: 195/553 - (35%)
• Gaps: 200/553 - (36%)

Human     1 MASP-------RTRKVLKEVRVQDENNVCFECGAFNPQWVSVTYGIWICLECSGRHRGLGVHLSF 58
            ||||       ....|...:|.|..|..||:|.|..|.|.||||||:||::||..||.|||||:|
  Fly     1 MASPAAGPSKQEIESVFSRLRAQPANKSCFDCAAKAPTWSSVTYGIFICIDCSAVHRNLGVHLTF 65

Human    59 VRSVTMD-KWKDIELEKMKAGGNAKFREFLESQEDYDPC--WSLQEKYNSRAAALFRDKVVALA- 119
            |||..:| .|..::|.:|:.||||...:|..:..    |  ...|.|||||||.|:|||:.|.|
  Fly    66 VRSTNLDTNWTWLQLRQMQLGGNANAAQFFRAHN----CSTTDAQVKYNSRAAQLYRDKLCAQAQ 126

Human   120 ------------------EGRE----------------WSLESSPAQNWTPPQPRTLP--SMVHR 148
                              ||.|                ::::::......|..|...|  |:..:
  Fly   127 QAMKTHGTKLHLEQTDKSEGNEAAREEDFFAQCDNEVDFNVQNNNVSKQDPNPPTVAPVISVETQ 191

Human   149 VSGQP-----QSVTASSDKAFEDWLNDDLGS-----YQGAQGNRYV-GFGNTP------------ 190
            ..|.|     .||..::       :...:|:     .:|..|.|.| |.|.|.
  Fly   192 QGGAPSVNLLNSVVPAA-------VPSSIGARKVQPKKGGLGARKVGGLGATKVKTNFADIEARA 249

Human   191 ----------------PPQKKEDDFLNNAMSSLYSGWSSFTTGASRFASAAKEGATKFGSQASQK 239
                            .||..||:.  ..::|:...:...:...:|..:..|........|..:.
  Fly   250 NAANEMKTSAAAAPVVKPQTAEDEL--ETVASMRLAYQELSMQKTREEAKLKTMDPAKAKQMERL 312

Human   240 FWGHKQQPEPASELGHSL---NENVLKPAQEKVK-----------EGKIFDDVSSGVSQLASKVQ 290
            ..|...:   .|::.||.   .|.:.:.|..|.|           :..::.:.|||..
  Fly   313 GMGFNLR---GSDMAHSALGDMETIQQSAAPKAKLSLLESENFFTDFSLYGNSSSGGG------- 367

Human   291 GVGSKGWRDVTTFFSGKAEGPLDSPSEGHSYQNSGLDHFQ---------------NSNIDQSF-- 338
            |.||          |.|.|..:...|:        ||.|:               :|||...|
  Fly   368 GGGS----------SEKRESSVGGTSK--------LDKFELDALGYETIEPIGGSHSNITSMFSR 414

Human   339 ---WETFGSAEPTKTRKSPSSDSWTCADTST-----------------------ERRSSDSWEVW 377
               ::...::.|.| :.|.||.:.|...|||                       |:.|:|.
  Fly   415 SNDYDKPKTSAPVK-KNSGSSQTHTKGGTSTDPVIAQQKFGNSKGFGSDQYFASEQSSADV---- 474

Human   378 GSASTNRNSNS----------DGGEGGEGTKKA 400
             |||.||...|          ||..||.|..:|
  Fly   475 -SASLNRFQGSRAISSSDYFGDGSPGGTGGNRA 506

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ARFGAP1	XP_011527203.1	ArfGap_ArfGap1	6..121	CDD:350059	55/136 (40%)
ArfGAP3	NP_001097664.2	ArfGap_ArfGap2_3_like	12..127	CDD:350060	55/118 (47%)