Protein Alignment VPS35 and VPS35

DIOPT Version :10

• Sequence 1: NP_060676.2
• Gene: VPS35 / 55737
• HGNCID: 13487
• Length: 796
• Species: Homo sapiens
• Sequence 2: NP_012381.1
• Gene: VPS35 / 853287
• SGDID: S000003690
• Length: 944
• Species: Saccharomyces cerevisiae
• Alignment Length: 873
• Identity: 290/873 - (33%)
• Similarity: 465/873 - (53%)
• Gaps: 130/873 - (14%)

Human    17 DEAIQAVKVQSFQMKRCLDKNKLMDALKHASNMLGELRTSMLSPKSYYELYMAISDELHYLEVYL 81
            :.||..:|.::..|.|||.::|||::|:|.|.||.|||...||||.|||||:.|.|.|..|..||
Yeast     8 ENAIAVIKQRTALMNRCLSQHKLMESLQHTSIMLTELRNPNLSPKKYYELYVIIFDSLTNLSTYL 72

Human    82 TDEFAKGRKVADLYELVQYAGNIIPRLYLLITVGVVYVKSFPQSRKDILKDLVEMCRGVQHPLRG 146
            .:...:...:|||||||||.||::|||||:||||..|:......:|:||||::|||||||:|:||
Yeast    73 IENHPQNHHLADLYELVQYTGNVVPRLYLMITVGTSYLTFNEAPKKEILKDMIEMCRGVQNPIRG 137

Human   147 LFLRNYLLQCTRNILPDEGEPTDEETTGDISDSMDFVLLNFAEMNKLWVRMQHQGHSRDREKRER 211
            ||||.||.|.|:.:||::          |.|.:..|::.||.||||||||:||||..|:||.|.|
Yeast   138 LFLRYYLSQRTKELLPED----------DPSFNSQFIMNNFIEMNKLWVRLQHQGPLRERETRTR 192

Human   212 ERQELRILVGTNLVRLSQLEGVNVERYKQIVLTGILEQVVNCRDALAQEYLMECIIQVFPDEFHL 276
            ||:||:||||:.||||||:...|.:.|||.:|..|||||:.|||.::||||::.|.|||.|||||
Yeast   193 ERKELQILVGSQLVRLSQIIDDNFQMYKQDILPTILEQVIQCRDLVSQEYLLDVICQVFADEFHL 257

Human   277 QTLNPFLRACAELHQNVNVKNIIIALIDRLALFAHR--EDGPGIPA-----DIKLFDIFSQQVAT 334
            :||:..|:....|:.:|::..|::.|:|||..:..|  ||.|...:     |:.:|..|...:..
Yeast   258 KTLDTLLQTTLHLNPDVSINKIVLTLVDRLNDYVTRQLEDDPNATSTNAYLDMDVFGTFWDYLTV 322

Human   335 VIQSRQDMPSEDVVSLQVSLINLAMKCYPDRVDYVDK----VLETTVEIFNK---LNLEH---IA 389
            :...|.|:..:..:.|..|:|.|::|.||:..|.::|    ||:.|.:...|   |..||   :.
Yeast   323 LNHERPDLSLQQFIPLVESVIVLSLKWYPNNFDNLNKLFELVLQKTKDYGQKNISLESEHLFLVL 387

Human   390 TSSAVSK-ELTRLLKIPVDTYNNILTVLKLKHFHPLFE-------YFDYESRKSMSCY--VLSNV 444
            .|...|| :||.....|.::     .|...|||  :|:       |.:..:.:|:|..  |::.:
Yeast   388 LSFQNSKLQLTSSTTAPPNS-----PVTSKKHF--IFQLISQCQAYKNILALQSISLQKKVVNEI 445

Human   445 LD-----------------------YNTEIVSQD--QVDSIMNLVSTLIQDQPDQPVEDPDPEDF 484
            :|                       ::..:|.:|  ||..::::...||..:...|......:..
Yeast   446 IDILMDREVEEMADNDSESKLHPPGHSAYLVIEDKLQVQRLLSICEPLIISRSGPPANVASSDTN 510

Human   485 ADE-----------------QSLVGRFIHLLRSEDPDQQYL-------------ILNTARKHFGA 519
            .||                 |..:...||.:.:....:|.:             ||...:..|..
Yeast   511 VDEVFFNRHDEEESWILDPIQEKLAHLIHWIMNTTSRKQTMKNKIQFSLEAQLEILLLIKSSFIK 575

Human   520 GGNQRIRFTLPPLVFAAYQLAFR------YKENSKVDDK-----WEKKCQKIFSFAHQTISALIK 573
            || ..:::|.|.::...::|..:      |....:.|:|     :....:::|.|..:.|:.:..
Yeast   576 GG-INVKYTFPAIITNFWKLMRKCRMIQEYLLKKRPDNKTLLSHYSNLLKQMFKFVSRCINDIFN 639

Human   574 A---ELAELPLRLFLQGALAAGEIGFENHETVAYEFMSQAFSLYEDEISDSKAQLAAITLIIGTF 635
            :   ...:|.|:|.||.|:.|.::....   ::|:|.||||:::|:.:||||.||.|:..|..:.
Yeast   640 SCNNSCTDLILKLNLQCAILADQLQLNE---ISYDFFSQAFTIFEESLSDSKTQLQALIYIAQSL 701

Human   636 ERMK-CFSEENHEPLRTQCALAASKLLKKPDQGRAVSTCAHLFWSGRNTDKNGEE------LHGG 693
            ::.: .:.|..::.|..:|.|..||||||.||.|||..|:||:|:...::...||      ...|
Yeast   702 QKTRSLYKEAYYDSLIVRCTLHGSKLLKKQDQCRAVYLCSHLWWATEISNIGEEEGITDNFYRDG 766

Human   694 KRVMECLKKALKIANQCMDPSLQVQLFIEILNRYIYFY---EKENDAVTIQVLNQLIQKIREDLP 755
            |||:|||:::|::|:..||.....:|.:|||||.:|::   ::....::|:.:|.||:.|:.:|.
Yeast   767 KRVLECLQRSLRVADSIMDNEQSCELMVEILNRCLYYFIHGDESETHISIKYINGLIELIKTNLK 831

Human   756 NLESSEETEQINKHFHNTLEHLRLRRES 783
            :|:..:.:..:   ..|::..|.:..|:
Yeast   832 SLKLEDNSASM---ITNSISDLHITGEN 856

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
VPS35	NP_060676.2	Vps35	15..752	CDD:427414	285/840 (34%)
		Interaction with SNX3. /evidence=ECO:0000269|PubMed:24344282	25..44		7/18 (39%)
		Interaction with SNX3. /evidence=ECO:0000269|PubMed:24344282	205..215		6/9 (67%)
		Interaction with SLC11A2. /evidence=ECO:0000269|PubMed:24344282	438..796		100/427 (23%)
		Interaction with IGF2R cytoplasmic domain. /evidence=ECO:0000269|PubMed:15078903	500..693		58/226 (26%)
VPS35	NP_012381.1	Vps35	8..828	CDD:427414	290/873 (33%)