Protein Alignment VPS35 and vps35

DIOPT Version :10

• Sequence 1: NP_060676.2
• Gene: VPS35 / 55737
• HGNCID: 13487
• Length: 796
• Species: Homo sapiens
• Sequence 2: NP_588260.2
• Gene: vps35 / 2539462
• PomBaseID: SPCC777.13
• Length: 836
• Species: Schizosaccharomyces pombe
• Alignment Length: 802
• Identity: 284/802 - (35%)
• Similarity: 449/802 - (55%)
• Gaps: 67/802 - (8%)

Human    10 DEQEKLLDEAIQAVKVQSFQMKRCLDKNKLMDALKHASNMLGELRTSMLSPKSYYELYMAISDEL 74
            :|..:.|:|::...|..|..|:|.|...:||||.::.|..|.|:|.|.|:||.||||||...:.|
pombe     9 EEITRSLEESLNICKQSSRLMQRNLQTGRLMDAFRNCSISLVEMRNSALTPKQYYELYMFNMESL 73

Human    75 HYLEVYLTDEFAKG-RKVADLYELVQYAGNIIPRLYLLITVGVVYVKSFPQSRKDILKDLVEMCR 138
            ..|...|.:....| ..:.||||||||||:|:|||||:||||..|:::.....::|:.||::|||
pombe    74 RLLGGTLLETHLNGTHNLMDLYELVQYAGSIVPRLYLMITVGSAYLETPNALVREIMNDLLDMCR 138

Human   139 GVQHPLRGLFLRNYLLQCTRNILPDEGEPTDEETT---GDISDSMDFVLLNFAEMNKLWVRMQHQ 200
            ||||||||||||:|||..||..||...|  |||..   |.:.||:.|:::||.||||||||:||.
pombe   139 GVQHPLRGLFLRHYLLTQTRKGLPLGSE--DEEDASRKGTVLDSVKFLVINFTEMNKLWVRIQHL 201

Human   201 GHSRDREKRERERQELRILVGTNLVRLSQLEGVNVERYKQIVLTGILEQVVNCRDALAQEYLMEC 265
            |..::..||.:||.||::|||.|||||||| .::::.|:..||..|:||::.|||:||||||:|.
pombe   202 GPIKEFSKRTQERNELKVLVGLNLVRLSQL-NLDIDTYRDHVLPAIIEQIIECRDSLAQEYLVEV 265

Human   266 IIQVFPDEFHLQTLNPFLRACAELHQNVNVKNIIIALIDRLALFAHRE----------------- 313
            |.|.|.|..|||||:.:.....:|..:|||..:::|:::||..:..||
pombe   266 ICQAFSDNMHLQTLDTYFGTVIKLSPSVNVTQLVVAMLNRLTDYVQREYESDSSNEDESETVTEK 330

Human   314 ----------------DGPG---IPADIKLFDIFSQQVATVIQSRQDMPSEDVVSLQVSLINLAM 359
                            :.||   ||.:..:.::....|..|||||..:|.:.:||:..|::|..:
pombe   331 LGDIKINEEVQQKDEQECPGDKVIPPEYAIQEVLWSHVVEVIQSRSGLPLDCIVSILSSILNFFL 395

Human   360 KCYPDRVDYVDKVLETTVE-IFNKLNLEHIATSSAVSKELTRLLKIPVDTYNNILTVLKLKHFHP 423
            :|||.:..|.|:|.:...| |.|:.:|........:.|.|..:|.:|:..:.:....|:|::|.|
pombe   396 RCYPYKPQYADRVFQYINEHIINQPSLRSALHERPLQKSLCAILLLPLTYFPSFSYCLELQNFLP 460

Human   424 LFEYFDYESRKSMSCYVLSNVLDYNTEIVSQDQVDSIMNLVSTLIQDQPDQPVEDPDPEDFADEQ 488
            :|...|...|..::..::..:::....:....:...::..||.:|:.:         ..|..|:.
pombe   461 VFNAQDPNLRYDIARMIVQKIIEKGHSLSELTEAQELLGFVSVIIEKK---------GVDSLDDL 516

Human   489 SLVGRFIHLLRSEDPDQQYLILNTARKHFGAGGNQRIRFTLPPLVFAAYQLAFRYKENSKVDDKW 553
            ..|...:|.|.::||..|..||.:.:..|...| :.:::.||.:|.....||..::....:|  |
pombe   517 QNVALMVHYLNNDDPQIQIEILRSLKDTFIKAG-ENVKYLLPVVVNRCIFLARNFRIFKCMD--W 578

Human   554 EKKCQKIFSFAHQTISALIK-AELAELPLRLFLQGALAAGEIGFENHETVAYEFMSQAFSLYEDE 617
            .:|.:.::.|.:..|:.|.| .:..||.|.|:|..|..|.:   ||:...||||.:||||:||:.
pombe   579 AEKVRLLWEFVNTCINVLYKNGDSLELCLALYLSAAEMADQ---ENYPDFAYEFFTQAFSIYEES 640

Human   618 ISDSKAQLAAITLIIGTFERMKCFSEENHEPLRTQCALAASKLLKKPDQGRAVSTCAHLFW---S 679
            :.||:.|...:.:|||..::.:.||.::::.|.|:|.|.||||||||||...:...:||:|   |
pombe   641 VLDSELQYQQLLMIIGKLQKTRNFSVDDYDTLITKCTLYASKLLKKPDQCCGIYLASHLWWQVAS 705

Human   680 GRNTDKNGEELHGGKRVMECLKKALKIANQCMDPSLQVQLFIEILNRYIYFYEKENDAVTIQVLN 744
            |    ::.......|||:|||:|:||||:.|||....::|||.||.||.|:|::..:::..:.::
pombe   706 G----EDSRPFQDPKRVLECLQKSLKIADACMDQLTSLKLFINILERYFYYYDQHCESIIAKHIS 766

Human   745 QLIQKIREDLPNLESSEETEQI 766
            .||....:::.::..|...:.|
pombe   767 GLIDLTEQNMRSILISSPADLI 788

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
VPS35	NP_060676.2	Vps35	15..752	CDD:427414	281/781 (36%)
		Interaction with SNX3. /evidence=ECO:0000269|PubMed:24344282	25..44		8/18 (44%)
		Interaction with SNX3. /evidence=ECO:0000269|PubMed:24344282	205..215		4/9 (44%)
		Interaction with SLC11A2. /evidence=ECO:0000269|PubMed:24344282	438..796		100/333 (30%)
		Interaction with IGF2R cytoplasmic domain. /evidence=ECO:0000269|PubMed:15078903	500..693		65/196 (33%)
vps35	NP_588260.2	Vps35	14..774	CDD:427414	281/781 (36%)