Protein Alignment PRKAR1A and prkar1a

DIOPT Version :10

• Sequence 1: NP_002725.1
• Gene: PRKAR1A / 5573
• HGNCID: 9388
• Length: 381
• Species: Homo sapiens
• Sequence 2: NP_001025530.1
• Gene: prkar1a / 594933
• XenbaseID: XB-GENE-856481
• Length: 381
• Species: Xenopus tropicalis
• Alignment Length: 382
• Identity: 352/382 - (92%)
• Similarity: 362/382 - (94%)
• Gaps: 2/382 - (0%)

Human     1 MESGSTAASEEARSLRECELYVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKEEAKQI 65
            |.||||...|| |||||||.||.|||||.||||.||||||.||..|||||||||||||||||:|.
 Frog     1 MASGSTGGEEE-RSLRECEQYVHKHNIQQLLKDCIVQLCTVRPACPMAFLREYFERLEKEEARQT 64

Human    66 QNLQKAGTRTDSREDEISPPP-PNPVVKGRRRRGAISAEVYTEEDAASYVRKVIPKDYKTMAALA 129
            .|.||:|:|:||||||||||| .|.||||||||||||||||||||||||||||||||||||||||
 Frog    65 LNQQKSGSRSDSREDEISPPPHMNSVVKGRRRRGAISAEVYTEEDAASYVRKVIPKDYKTMAALA 129

Human   130 KAIEKNVLFSHLDDNERSDIFDAMFSVSFIAGETVIQQGDEGDNFYVIDQGETDVYVNNEWATSV 194
            |||||||||:|||||||||||||||||::||||||||||||||||||:||||.||||||:|.||:
 Frog   130 KAIEKNVLFAHLDDNERSDIFDAMFSVTYIAGETVIQQGDEGDNFYVVDQGEMDVYVNNDWMTSI 194

Human   195 GEGGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMGSTLRKRKMYEEFLSKVSILESL 259
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 Frog   195 GEGGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMGSTLRKRKMYEEFLSKVSILESL 259

Human   260 DKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIILEGSAAVLQRRSENEEFVEVGRLGPSDYF 324
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 Frog   260 DKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIILEGSAAVLQRRSENEEFVEVGRLGPSDYF 324

Human   325 GEIALLMNRPRAATVVARGPLKCVKLDRPRFERVLGPCSDILKRNIQQYNSFVSLSV 381
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 Frog   325 GEIALLMNRPRAATVVARGPLKCVKLDRPRFERVLGPCSDILKRNIQQYNSFVSLSV 381

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PRKAR1A	NP_002725.1	Dimerization and phosphorylation	1..136		113/135 (84%)
		DD_RIalpha_PKA	14..63	CDD:438522	41/48 (85%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	64..96		23/32 (72%)
		Pseudophosphorylation motif	96..100		3/3 (100%)
		CAP_ED	137..246	CDD:237999	100/108 (93%)
		CAP_ED	255..370	CDD:237999	114/114 (100%)
prkar1a	NP_001025530.1	DD_RIalpha_PKA	13..62	CDD:438522	41/48 (85%)
		CAP_ED	137..246	CDD:237999	100/108 (93%)
		CAP_ED	255..370	CDD:237999	114/114 (100%)