Protein Alignment PRKAR1A and for

DIOPT Version :10

• Sequence 1: NP_002725.1
• Gene: PRKAR1A / 5573
• HGNCID: 9388
• Length: 381
• Species: Homo sapiens
• Sequence 2: NP_477487.1
• Gene: for / 44817
• FlyBaseID: FBgn0000721
• Length: 1088
• Species: Drosophila melanogaster
• Alignment Length: 283
• Identity: 86/283 - (30%)
• Similarity: 146/283 - (51%)
• Gaps: 12/283 - (4%)

Human    94 RRRRGAISAEVYTEE----DAASYVRKVIPKDYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMF 154
            |:|...||||..:|.    :..|:.:  ..||.::...:..||..|....:||..:..:|.|.|:
  Fly   475 RQRALGISAEPQSESSLLLEHVSFPK--YDKDERSRELIKAAILDNDFMKNLDLTQIREIVDCMY 537

Human   155 SVSFIAGETVIQQGDEGDNFYVIDQGETDVYVNNEWATSVGEGGSFGELALIYGTPRAATVKAKT 219
            .|.:.|...:|::||.|...||::.|..:|....::.:::......||||::|...|.||:.|.|
  Fly   538 PVKYPAKNLIIKEGDVGSIVYVMEDGRVEVSREGKYLSTLSGAKVLGELAILYNCQRTATITAIT 602

Human   220 NVKLWGIDRDSYRRILMGSTLRKRKMYEEFLSKVSILESLDKWERLTVADALEPVQFEDGQKIVV 284
            ...||.|:|..::.|:|.:.|.::..|.:||..|.|.:.|.:...:.::|.||...::.|..||.
  Fly   603 ECNLWAIERQCFQTIMMRTGLIRQAEYSDFLKSVPIFKDLAEDTLIKISDVLEETHYQRGDYIVR 667

Human   285 QGEPGDEFFIILEGSAAVL--QRRSENEEFVEVGRLGPSDYFGEIALLMNRPRAATVVARGP--L 345
            ||..||.||||.:|...|.  |:.::.|:|:.:  ||..|:|||.||..:..|.|.::....  :
  Fly   668 QGARGDTFFIISKGKVRVTIKQQDTQEEKFIRM--LGKGDFFGEKALQGDDLRTANIICESADGV 730

Human   346 KCVKLDRPRFERVLGPCSDILKR 368
            .|:.:||..|.:::....:|..|
  Fly   731 SCLVIDRETFNQLISNLDEIKHR 753

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PRKAR1A	NP_002725.1	Dimerization and phosphorylation	1..136		12/45 (27%)
		DD_RIalpha_PKA	14..63	CDD:438522
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	64..96		1/1 (100%)
		Pseudophosphorylation motif	96..100		1/3 (33%)
		CAP_ED	137..246	CDD:237999	32/108 (30%)
		CAP_ED	255..370	CDD:237999	37/118 (31%)
for	NP_477487.1	DD_cGKI-alpha	385..432	CDD:213374
		CAP_ED	520..629	CDD:237999	32/108 (30%)
		CAP_ED	638..754	CDD:237999	37/118 (31%)
		STKc_cGK	783..1043	CDD:270724