DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PRKAR1A and Pka-R1

DIOPT Version :9

Sequence 1:	NP_001263218.1	Gene:	PRKAR1A / 5573	HGNCID:	9388	Length:	381	Species:	Homo sapiens
Sequence 2:	NP_001189150.1	Gene:	Pka-R1 / 40305	FlyBaseID:	FBgn0259243	Length:	464	Species:	Drosophila melanogaster

Alignment Length:	403	Identity:	257/403 - (63%)
Similarity:	296/403 - (73%)	Gaps:	38/403 - (9%)

- Green bases have known domain annotations that are detailed below.

Human    13 RSLRECELYVQKHNIQALLKDS---------------IVQLCTARPER-------------PMAF 49
            |.|||..:........|||:|.               :...||..||.             .:|.
  Fly    66 RILRESSIDGGVAMFDALLRDDHEHRLSLDAVHRMRHVRTSCTTIPEEDAVSDRSLQIHLSTLAR 130

Human    50 LREYFERLEKEEAKQIQNLQKAGTRTDSRED--EISPPPPN---PVVKGRRRRGAISAEVYTEED 109
            .||....||::..::.|....|..:..|.:|  ::||.|..   ||    ||||.||||..||||
  Fly   131 EREQELELERQREREEQVKLDASRQVISPDDCEDLSPMPQTAAPPV----RRRGGISAEPVTEED 191

Human   110 AASYVRKVIPKDYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFSVSFIAGETVIQQGDEGDNF 174
            |.:||:||:|||||||.||:|||.|||||:|||::||||||||||.|:.||||.:||||||||||
  Fly   192 ATNYVKKVVPKDYKTMNALSKAIAKNVLFAHLDESERSDIFDAMFPVNHIAGENIIQQGDEGDNF 256

Human   175 YVIDQGETDVYVNNEWATSVGEGGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMGST 239
            ||||.||.||:||:|..|::.||||||||||||||||||||:|||:|||||||||||||||||||
  Fly   257 YVIDVGEVDVFVNSELVTTISEGGSFGELALIYGTPRAATVRAKTDVKLWGIDRDSYRRILMGST 321

Human   240 LRKRKMYEEFLSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIILEGSAAVLQ 304
            :|||||||||||:|||||||||||||||||:||...|:||:.||.||..||:|:|||||.|.|||
  Fly   322 IRKRKMYEEFLSRVSILESLDKWERLTVADSLETCSFDDGETIVKQGAAGDDFYIILEGCAVVLQ 386

Human   305 RRSE-NEEFVEVGRLGPSDYFGEIALLMNRPRAATVVARGPLKCVKLDRPRFERVLGPCSDILKR 368
            :||| .|:..||||||.||||||||||::||||||||||||||||||||.|||||||||:|||||
  Fly   387 QRSEQGEDPAEVGRLGSSDYFGEIALLLDRPRAATVVARGPLKCVKLDRARFERVLGPCADILKR 451

Human   369 NIQQYNSFVSLSV 381
            ||.||||||||||
  Fly   452 NITQYNSFVSLSV 464

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PRKAR1A	NP_001263218.1	Dimerization and phosphorylation	1..136		56/155 (36%)
		DD_RIalpha_PKA	14..63	CDD:213048	16/76 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	64..96		9/36 (25%)
		Pseudophosphorylation motif	96..100		3/3 (100%)
		CAP_ED	137..246	CDD:237999	88/108 (81%)
		CAP_ED	255..370	CDD:237999	90/115 (78%)
Pka-R1	NP_001189150.1	Crp	213..>339	CDD:223736	103/125 (82%)
		CAP_ED	219..328	CDD:237999	88/108 (81%)
		Crp	331..>442	CDD:223736	85/110 (77%)
		CAP_ED	337..453	CDD:237999	90/115 (78%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	139	1.000	Domainoid score	I4795
eggNOG	1	0.900	-	-		E1_COG0664
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H37664
Inparanoid	1	1.050	542	1.000	Inparanoid score	I1184
Isobase	1	0.950	-	0	Normalized mean entropy	S867
OMA	1	1.010	-	-		QHG54324
OrthoDB	1	1.010	-	-		D1047290at2759
OrthoFinder	1	1.000	-	-		FOG0000531
OrthoInspector	1	1.000	-	-		otm41341
orthoMCL	1	0.900	-	-		OOG6_100449
Panther	1	1.100	-	-	LDO	PTHR11635
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2591
SonicParanoid	1	1.000	-	-		X421
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.820