DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PRKAR1A and Pka-R2

DIOPT Version :9

Sequence 1:	NP_001263218.1	Gene:	PRKAR1A / 5573	HGNCID:	9388	Length:	381	Species:	Homo sapiens
Sequence 2:	NP_523671.1	Gene:	Pka-R2 / 36041	FlyBaseID:	FBgn0022382	Length:	377	Species:	Drosophila melanogaster

Alignment Length:	386	Identity:	146/386 - (37%)
Similarity:	222/386 - (57%)	Gaps:	36/386 - (9%)

- Green bases have known domain annotations that are detailed below.

Human     1 MESGSTAASEEARSLRECELYVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKEEAKQI 65
            |.|.|:...:....|:|           .||:.|| .....:|...:.:..|||.:|:.|
  Fly     1 MSSDSSRRIQVPEELKE-----------VLLQFSI-SFLVEQPPDVIDYAVEYFTKLQSE----- 48

Human    66 QNLQKAGTRTD-SREDEIS----PPPPNPVVKGRRRRGAISAEVY-----TEEDAASYVRKVIPK 120
               :.:.:.|| |.:|::|    .....|.|....||.::.||.|     .::|.|:   .|.||
  Fly    49 ---RPSVSHTDQSTDDQLSVNSQDADAEPPVMASSRRKSVFAEAYDPEADDDDDGAT---AVFPK 107

Human   121 DYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFSVSFIAGETVIQQGDEGDNFYVIDQGETDVY 185
            ..:..|.|.::::..:||..|:..:.:.:.||||......|:.:|:|||:|||||||:.|...||
  Fly   108 TDEQRARLVESVKNVLLFRSLEKEQMNQVLDAMFERKVQPGDFIIRQGDDGDNFYVIESGVYKVY 172

Human   186 VNNEWATSVGEGGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMGSTLRKRKMYEEFL 250
            :|::...:....|.||||||:|..||||||:|:|:..||.:||.::||||:.|..||||||||.|
  Fly   173 INDKHINTYNHTGLFGELALLYNMPRAATVQAETSGLLWAMDRQTFRRILLKSAFRKRKMYEELL 237

Human   251 SKVSILESLDKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIILEGSAAVLQRRSENEEFVEV 315
            :.|.:|::|..:||:.:||||....:::|::|:.||:..|..:.|.||:.:|  |..:::..||:
  Fly   238 NSVPMLKALQNYERMNLADALVSKSYDNGERIIKQGDAADGMYFIEEGTVSV--RMDQDDAEVEI 300

Human   316 GRLGPSDYFGEIALLMNRPRAATVVAR-GPLKCVKLDRPRFERVLGPCSDILKRNIQQYNS 375
            .:||...||||:||:.:|||||:|.|. |.:|...||...|||:||||.||:||||..|.|
  Fly   301 SQLGKGQYFGELALVTHRPRAASVYATGGVVKLAFLDVKAFERLLGPCMDIMKRNIDDYES 361

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PRKAR1A	NP_001263218.1	Dimerization and phosphorylation	1..136		34/144 (24%)
		DD_RIalpha_PKA	14..63	CDD:213048	12/48 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	64..96		7/36 (19%)
		Pseudophosphorylation motif	96..100		2/3 (67%)
		CAP_ED	137..246	CDD:237999	52/108 (48%)
		CAP_ED	255..370	CDD:237999	50/115 (43%)
Pka-R2	NP_523671.1	DD_RII_PKA	11..49	CDD:213046	12/57 (21%)
		CAP_ED	124..233	CDD:237999	52/108 (48%)
		CAP_ED	242..356	CDD:237999	50/115 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0664
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54324
OrthoDB	1	1.010	-	-		D1047290at2759
OrthoFinder	1	1.000	-	-		FOG0000531
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100449
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2591
SonicParanoid	1	1.000	-	-		X421
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.760