Protein Alignment PRKAR1A and CG4839

DIOPT Version :10

• Sequence 1: NP_002725.1
• Gene: PRKAR1A / 5573
• HGNCID: 9388
• Length: 381
• Species: Homo sapiens
• Sequence 2: NP_609349.1
• Gene: CG4839 / 34348
• FlyBaseID: FBgn0032187
• Length: 1003
• Species: Drosophila melanogaster
• Alignment Length: 447
• Identity: 118/447 - (26%)
• Similarity: 190/447 - (42%)
• Gaps: 93/447 - (20%)

Human     8 ASEEARSLRECELYVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKEEAKQIQNLQK-- 70
            ::::......|:.....:|..|.|.:.:|.  ..:|||.|.          |::|.|.....|
  Fly   236 SAQQTDDTLSCQSSDANNNSAAKLTNGVVP--QEQPEREMG----------KQQALQAPPRAKSS 288

Human    71 --------AGTRTDSR---------EDEISPPPPNP---VVKG-----RRRRG------------ 98
                    |.::|||:         :..|.|.||.|   :|.|     |::|.
  Fly   289 SNVSLNYLAKSQTDSQRRRRVSTMPDINIPPAPPLPPELLVPGTPLHLRKKRSMERQQQQKQQEQ 353

Human    99 -----------------AISAEVYTEEDAAS-----------YVRKVIP-----------KDYKT 124
                             |.:.|.:...|:::           |||...|           ||..|
  Fly   354 QQQQEIQQDATNSQDQMAGAEESHKSSDSSTPKTHRVEGGLIYVRPNFPIQSDIEIESIAKDEGT 418

Human   125 MAALAKAIEKNVLFSHLDDNERSD-IFDAMFSVSFIAGETVIQQGDEGDNFYVIDQGETDVYVNN 188
            ...:..|||:|...::|.|.||.: :.:||...|:.....:|::.:||...||..:|:.||....
  Fly   419 RNLIRTAIERNDFLNNLMDKERKEMVINAMAPASYRKHSLIIREHEEGSEIYVSAEGQYDVIRGG 483

Human   189 EWATSVGEGGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMGSTLRKRKMYEEFLSKV 253
            :...|.|....|||||::|..||.|:::|.|:.::|.|.|:::|.|:..|..|:|:...:||...
  Fly   484 QLVASFGPATVFGELAILYNAPRQASIEAATDARVWKIARETFRAIMQISGSREREENLQFLRSA 548

Human   254 SILESLDKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIILEGSAAVLQRRSENEEFVEVGRL 318
            ..|:..|:...|.|.|.|:...:|....||.:||.|:||:||..|:..:.:...:.:|.:...|
  Fly   549 PFLQEFDQSLLLKVVDLLQRKFYETDSCIVREGELGNEFYIIRCGTVTIKKLDEQQQEQIVANR- 612

Human   319 GPSDYFGEIALLMNRPRAATVVARGP-LKCVKLDRPRFERVLGPCSDILKRNIQQYN 374
            ...|||||.|||....|.|:|.|..| .:.:.|||..|...||....:.::...|.|
  Fly   613 KRGDYFGEQALLNADVRQASVYADAPGTEVLMLDREAFISYLGTIKQLREKPSSQRN 669

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PRKAR1A	NP_002725.1	Dimerization and phosphorylation	1..136		39/205 (19%)
		DD_RIalpha_PKA	14..63	CDD:438522	10/48 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	64..96		14/58 (24%)
		Pseudophosphorylation motif	96..100		1/32 (3%)
		CAP_ED	137..246	CDD:237999	36/109 (33%)
		CAP_ED	255..370	CDD:237999	38/115 (33%)
CG4839	NP_609349.1	CAP_ED	431..539	CDD:237999	35/107 (33%)
		CAP_ED	550..663	CDD:237999	38/113 (34%)
		STKc_cGK	700..957	CDD:270724