Protein Alignment kcnf1a and Shawl

DIOPT Version :10

• Sequence 1: NP_001076280.1
• Gene: kcnf1a / 557280
• ZFINID: ZDB-GENE-041001-217
• Length: 494
• Species: Danio rerio
• Sequence 2: NP_001097131.2
• Gene: Shawl / 5740840
• FlyBaseID: FBgn0085395
• Length: 937
• Species: Drosophila melanogaster
• Alignment Length: 565
• Identity: 147/565 - (26%)
• Similarity: 233/565 - (41%)
• Gaps: 175/565 - (30%)

Zfish    20 ETEISVNIGGVKHTLYGDVLNRYPETRLAELLNRVSDSAEDLSGLCDDYDDLKREFYFDRDPKAF 84
            |..|.:|:.|:::..|...|.:.|.|||:.|...::           :||.:..|::|||.|..|
  Fly     4 ENRIILNVSGIRYETYKATLKKIPATRLSRLTEALA-----------NYDPVLNEYFFDRHPGVF 57

Zfish    85 KCILELYYYGEIHMKRGICPMCFMKEMDYWGIDEDYLDECCRCSLN---EVETELAEIAEKVKTI 146
            ..||..|..|::|....:|...|.:|:::||:|.:.::.||..:.:   :.:..||        |
  Fly    58 TQILNYYRTGKLHYPTDVCGPLFEEELEFWGLDSNQVEPCCWSTYSIHRDTQNTLA--------I 114

Zfish   147 LDDLE-DDDDDDDARVSRS---------------QRCQTFLWKLMEKPESSVAARVIAVVSFVFI 195
            ||.|: :::...:.:::|.               ||.:..:|.:.::|.||..|:::|.:|..||
  Fly   115 LDKLDIENEKPTEEQIARLFGFEEALSNGELNCWQRIKPKIWAMFDEPSSSTGAKIVAGMSVFFI 179

Zfish   196 LLSSVVMCVGTIPELQVQDDEGHLTEH------------------------------------PT 224
            .:|.:..|:.|.|..:|....|....|                                    ||
  Fly   180 FVSVISFCLKTHPGFRVDLPSGAHDAHGPGAGGPPHGHDPMGEPPQTHQYHQHSITPPSGSIGPT 244

Zfish   225 LEA-------------------------------------------------------------- 227
            ...
  Fly   245 FRVTNYTSYSSGNFTASGQATPIATIKGGQRQRLKRNINGSILNEFIEEKILGHNGRRKHGWIET 309

Zfish   228 ----------IETACIIWFTVEYVLRLASSSSKLHFVFSFLNIIDFLAIMPFYVVLILTHLGTAM 282
                      :|..|.:||.:|.::||..|.:...|:.|.:|||||.|.:.||.        ..|
  Fly   310 YGQPHEAFFYVELVCNVWFFIEVIIRLIVSPNLWQFIKSPVNIIDFTATLSFYT--------DVM 366

Zfish   283 MELANVQQAVQALRIMRIARIFKLARHSSGLQTLTFALKSSLKELGLLLMYMSVGIFLFSALGYT 347
            ..:......::|..|:||.|:|||.|||.||:.|....|:|.|||.||:.::.:||..|::|.|.
  Fly   367 QRMGEYTGLLEAFSIVRIMRLFKLTRHSPGLRILIHTFKASAKELTLLVFFLVLGIVFFASLAYY 431

Zfish   348 ME--QSHPETMFTSIPQSFWWAIITMTTVGYGDIYPKTTLGRCNAAVSFLCGVIAIALPIHPIIN 410
            .|  |.:|:..|.|||...||||:|||||||||:.|||..|....|:..|.||:.||||:..|::
  Fly   432 AEKLQDNPDNQFKSIPLGLWWAIVTMTTVGYGDVAPKTYPGMFVGALCALAGVLTIALPVPVIVS 496

Zfish   411 NFVIVYSKQRVLETAAKHEIELMALRAREEAQECPEAERRAASVD 455
            ||.:.||     .|.|:.::              |:..||...|:
  Fly   497 NFSMFYS-----HTQARSKL--------------PKKRRRVLPVE 522

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kcnf1a	NP_001076280.1	BTB_POZ_Kv5_KCNF1	21..136	CDD:349690	31/117 (26%)
		Ion_trans	184..420	CDD:459842	96/345 (28%)
Shawl	NP_001097131.2	BTB_Shaw-like	4..115	CDD:349723	34/129 (26%)
		Ion_trans	307..506	CDD:459842	82/211 (39%)