DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RADIL and MYO4

DIOPT Version :9

Sequence 1:	NP_060529.4	Gene:	RADIL / 55698	HGNCID:	22226	Length:	1075	Species:	Homo sapiens
Sequence 2:	NP_009373.1	Gene:	MYO4 / 851204	SGDID:	S000000027	Length:	1471	Species:	Saccharomyces cerevisiae

Alignment Length:	308	Identity:	62/308 - (20%)
Similarity:	122/308 - (39%)	Gaps:	61/308 - (19%)

- Green bases have known domain annotations that are detailed below.

Human   507 LFWMSNSIELLYFIQQKCPLYMQSMEEQLDITGSKESLFSCTLTASE-EAMAVLEEVVLYAFQQC 570
            :||:||...|..|...:..||..:..::      |:.|....|...| |.:.|.:::......:.
Yeast  1187 IFWLSNLSRLPAFAANQKTLYEANGGDE------KDKLTLIYLNDLENETLKVFDKIYSTWLVKF 1245

Human   571 VYYVSKSLYICLPALLECPPFQTERRESWSSAPELPEELRRVVSVYQAALDLLRQLQVHPEVASQ 635
            :.:.|..:.| ...:|....|:....|.::.......|...|:..:| .:|     .:|.::.:.
Yeast  1246 MKHASAHIEI-FDMVLNEKLFKNSGDEKFAKLFTFLNEFDAVLCKFQ-VVD-----SMHTKIFND 1303

Human   636 MLAYLFFFSGTLLLNQLLDRGPSLSCFHWPRGVQACARLQQLLEWMRSAGFGAAGEHFFQKL-SC 699
            .|.||    ..:|.|.|:.:.|:|   :|..|.:....:::|:.|            |..:: ..
Yeast  1304 TLKYL----NVMLFNDLITKCPAL---NWKYGYEVDRNIERLVSW------------FEPRIEDV 1349

Human   700 TLNLLATPRA-QLIQMSWTAL---RAAFP---ALSPAQLHRLLTHYQLASAMGPMSTWEPGAQDS 757
            ..||:...:| :::|:..:.|   :..|.   ||:|||:..:|..|:      |.:..|.|..:
Yeast  1350 RPNLIQIIQAVKILQLKISNLNEFKLLFDFWYALNPAQIQAILLKYK------PANKGEAGVPN- 1407

Human   758 PEAFRSEDVLESYEN---PPPIVLPSDGFQVDLEANCLDDSIYQHLLY 802
                   ::|....|   ...:.||.   ::::..:...||...||.|
Yeast  1408 -------EILNYLANVIKRENLSLPG---KMEIMLSAQFDSAKNHLRY 1445

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RADIL	NP_060529.4	RA	61..164	CDD:279168
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	183..237
		FHA	273..343	CDD:278899
		Myo5p-like_CBD_Rasip1	414..779	CDD:271256	55/283 (19%)
		DUF4764	<809..935	CDD:292583
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	872..967
		PDZ_signaling	974..1058	CDD:238492
MYO4	NP_009373.1	COG5022	2..1471	CDD:227355	62/308 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0160
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900