DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RADIL and rasip1

DIOPT Version :9

Sequence 1:	NP_060529.4	Gene:	RADIL / 55698	HGNCID:	22226	Length:	1075	Species:	Homo sapiens
Sequence 2:	XP_004916310.1	Gene:	rasip1 / 100493560	XenbaseID:	XB-GENE-6033970	Length:	935	Species:	Xenopus tropicalis

Alignment Length:	895	Identity:	334/895 - (37%)
Similarity:	496/895 - (55%)	Gaps:	122/895 - (13%)

- Green bases have known domain annotations that are detailed below.

Human    12 PTKSKLKRQSQL--------------LSSMLSRTLSYKYRDLDSTFSSLGASDDPAELSTQLSAP 62
            |||:|..|..:|              :||...|.:|.|  .|.....::  .:|..|||:|.:.|
Frog    64 PTKNKNNRHKRLSNLFHRSTNSIAGSISSGTGRWVSEK--KLSEIIDTV--PEDLVELSSQKNLP 124

Human    63 GVLKVFGDSVCTGTHYKSVLATGTSSARELVKEALERYALDPRQAGQYVLCDVVGQAGDAGQRWQ 127
            |:||:|||.:.:||:|||||||..|||.|||||||||||:...:...:|||||||:.......|:
Frog   125 GILKIFGDDISSGTNYKSVLATPRSSAEELVKEALERYAVADSETEVFVLCDVVGRFVGLEGEWK 189

Human   128 ARCFRVFGDSEKPLLIQELWKPREGLSRRFELRKRSDVEELAAKEVDTITAGINAQARRLQRSRA 192
            ....||.||:|:||::||:|||:.|.|||||:|::.:||::...| |..||||||||||||:||:
Frog   190 MEYLRVVGDNERPLVLQEMWKPKTGFSRRFEIRRKQEVEKMTMAE-DNETAGINAQARRLQKSRS 253

Human   193 KGTPTPALGDARSSPPPR-------LRRTVSETSLSPV-----NALPAAAQGPEEPGPDAMRYSL 245
            :..       :..:.|.|       |||::|:.:::..     .::.:......:||.|     |
Frog   254 RAA-------SGGNAPLREREESISLRRSISDVNINSKKRRERKSIKSMVANDGDPGQD-----L 306

Human   246 YQS---------------------------------------------PHLLLLQGYSQQHDSLV 265
            .||                                             |:.||||||::..|.::
Frog   307 SQSQKDGISEMKNLSEGDRNVDRDDSADQMDLDFERLSQCLIQPPAEHPYFLLLQGYNKDQDFVI 371

Human   266 YVLNRDRHTVGQRTPSSK---PSIS--LSAPDILPLHCTIRRQPLPDSGQAAGRLV-LEPIPGAH 324
            ||:.|.:|..|:...|.:   |.:.  ||||||||.||::.|  |..|||.  .:| :.|..||.
Frog   372 YVMTRKKHLFGRAEKSLRDKGPYVDTFLSAPDILPRHCSVWR--LDSSGQK--YIVRVRPYRGAL 432

Human   325 ISVNFSEVGHRTVVLHHGDLLSLGLYYLLLFKDPAQAQPLPARALARLRAVPQ-----SCRLCGA 384
            ::.| ..|..|...||.||||.||.::|.::|||...|..|| .|.:..:.|.     ||::||.
Frog   433 VTHN-GRVLQRETELHTGDLLGLGEHFLFMYKDPRMPQGRPA-WLPKSWSSPSLSGAFSCQMCGR 495

Human   385 ALGARGAASPTQAALPRRQQLLLEFEPHLEDTLLQRIMTLIEPGGDDHKLTPAFLLCLCIQHSAT 449
            :|..:..|  .||.:..|:. :|::....||::|:.|:......|.|.||.||:|..||::||..
Frog   496 SLQEKQEA--VQAYIESREP-VLQYRSQEEDSVLKEIIEKTGNPGSDFKLAPAYLFSLCLEHSTK 557

Human   450 HFQPGTFGQLLLKIARLIRETVWEKTKELAEKQAQLQEPISLASCAMA--DLVPDLQPILFWMSN 512
            ...||.|.:|::|||..|:|.||||.||:.:||.:.|:...| .||:.  ::..||:|::.||||
Frog   558 ALDPGHFPKLVMKIASFIKEVVWEKIKEIGDKQPENQQDRGL-PCALGIEEVATDLRPLMLWMSN 621

Human   513 SIELLYFIQQKCPLYMQSMEEQLDITG-SKESLFSCTLTASEEAMAVLEEVVLYAFQQCVYYVSK 576
            |:|||.|:|:|    :..:|::.:..| |:::|.|..:.|.||:||:|:||::|.|||||||::|
Frog   622 SMELLNFVQRK----ILDLEKEWESEGSSQDTLLSSDIEACEESMALLDEVIMYTFQQCVYYLTK 682

Human   577 SLYICLPALLECPPFQTERRESWSSAPEL---PEELRRVVSVYQAALDLLRQLQVHPEVASQMLA 638
            :||..||||||..||...  .|.|...||   ||..|..:::|||.|||.|:.::||::.||...
Frog   683 TLYAALPALLESNPFTDP--ASLSDVGELSNMPEGTRGTLAIYQATLDLTRECELHPDLVSQTFG 745

Human   639 YLFFFSGTLLLNQLLDRGPSLSCFHWPRGVQACARLQQLLEWMRSAGFGAAGEHFFQKLSCTLNL 703
            ||||||...|.|.|:::|.....:.|.:.||....|..:|:|::..|.|.....||:|||.|:||
Frog   746 YLFFFSNASLFNTLMEKGNGEPFYQWSKAVQIRTNLDLVLDWLQGIGLGDIAAEFFRKLSATVNL 810

Human   704 LATPRAQLIQMSWTALRAAFPALSPAQLHRLLTHYQLASAMGPMSTWEPGAQDSPEAFRSEDVLE 768
            |..|:..|:::||:.||..:||||.|||:.||.:|.|.......:.||| .::..|...:.|:.|
Frog   811 LCIPKTSLMKVSWSTLRNDYPALSSAQLNHLLRNYHLGVGRSHPAAWEP-PEEEKEEITNTDIFE 874

Human   769 SYENPPPIVLPSDGFQVDLEANCLDDSIYQHLLYVRHFLWGLRSRASPGS 818
            |:...||::||.:.|::.|.....||:.|..|..:|.|:|.|..::.|.:
Frog   875 SFTEHPPLILPCENFRLQLAQPINDDAFYGQLCQLRRFVWDLEQKSLPAN 924

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RADIL	NP_060529.4	RA	61..164	CDD:279168	57/102 (56%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	183..237		14/65 (22%)
		FHA	273..343	CDD:278899	28/75 (37%)
		Myo5p-like_CBD_Rasip1	414..779	CDD:271256	153/370 (41%)
		DUF4764	<809..935	CDD:292583	2/10 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	872..967
		PDZ_signaling	974..1058	CDD:238492
rasip1	XP_004916310.1	RA_Radil_like	112..223	CDD:340636	61/110 (55%)
rasip1	XP_004916310.1	Myo5p-like_CBD_Rasip1	520..885	CDD:271256	153/372 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG43108
OrthoDB	1	1.010	-	-		D213862at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm54151
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.930